Li, Yang’s team published research in Small in 15 | CAS: 92-36-4

Small published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, COA of Formula: C14H12N2S.

Li, Yang published the artcileNear-Infrared Activated Black Phosphorus as a Nontoxic Photo-Oxidant for Alzheimer’s Amyloid-β Peptide, COA of Formula: C14H12N2S, the publication is Small (2019), 15(24), n/a, database is CAplus and MEDLINE.

The inhibition of amyloid-β (Aβ) aggregation by photo-oxygenation has become an effective way of treating Alzheimer’s disease (AD). New near-IR (NIR) activated treatment agents, which not only possess high photo-oxygenation efficiency, but also show low biotoxicity, are urgently needed. Herein, for the first time, it is demonstrated that NIR activated black phosphorus (BP) could serve as an effective nontoxic photo-oxidant for amyloid-β peptide in vitro and in vivo. The nanoplatform BP@BTA (BTA: one of thioflavin-T derivatives) possesses high affinity to the Aβ peptide due to specific amyloid selectivity of BTA. Importantly, under NIR light, BP@BTA can significantly generate a high quantum yield of singlet oxygen (1O2) to oxygenate Aβ, thereby resulting in inhibiting the aggregation and attenuating Aβ-induced cytotoxicity. In addition, BP could finally degrade into nontoxic phosphate, which guarantees the biosafety. Using transgenic Caenorhabditis elegans CL2006 as AD model, the results demonstrate that the 1O2-generation system could dramatically promote life-span extension of CL2006 strain by decreasing the neurotoxicity of Aβ.

Small published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, COA of Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Hou, Yue’s team published research in Dyes and Pigments in 160 | CAS: 95-24-9

Dyes and Pigments published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, COA of Formula: C7H5ClN2S.

Hou, Yue published the artcileRewritable optical data storage based on mechanochromic fluorescence materials with aggregation-induced emission, COA of Formula: C7H5ClN2S, the publication is Dyes and Pigments (2019), 830-838, database is CAplus.

In this work, the synthesis and aggregation-induced emission (AIE) properties of a new mol. system are reported. This system composes of three positional isomers, which are fabricated by attaching a methoxy group in different locations. The isomeric effects on the AIE properties as well as the intramol. charge transfer (ICT) processes were studied. Addnl. the new isomers exhibit mechanochromic fluorescence (MCF). Among the three isomers, (E)-2-(((6-chlorobenzo[d]thiazol-2-yl)imino)methyl)-5-methoxyphenol (CHM3) exhibits the most remarkable MCF performance with emission that decreases in intensity and red-shifts in wavelength under mech. stimuli. The emission changes are caused by crystalline-amorphous transition as verified by Powder X-ray diffraction (PXRD) anal. The mechano-induced state can be easily recovered through a recrystallization process, which can be activated by solvent fumigation or solvent immersion. Furthermore, the switching between two emission states shows nice reversibility. Based on the MCF material with high fatigue resistance, a new type of rewritable optical data storage (ODS) is developed. Binary data, comprised of “0” and “1” state, can be matched well with the two emission states, resp. The data could thus be written or erased on the ODS device, demonstrating feasibility and practicability.

Dyes and Pigments published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, COA of Formula: C7H5ClN2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Haasnoot, Willem’s team published research in Food and Agricultural Immunology in 12 | CAS: 64987-16-2

Food and Agricultural Immunology published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C6H8N2O2S, Application of Methyl 2-(2-aminothiazol-4-yl)acetate.

Haasnoot, Willem published the artcileMonoclonal antibodies against a sulfathiazole derivative for the immunochemical detection of sulfonamides, Application of Methyl 2-(2-aminothiazol-4-yl)acetate, the publication is Food and Agricultural Immunology (2000), 12(2), 127-138, database is CAplus.

To prepare monoclonal antibodies (mAbs) against the generic part of sulfonamides, a sulfathiazole derivative was chem. linked to carrier proteins in such a way that the aromatic amino group, common to all sulfonamides, was distal to the proteins. Four mice were immunized with the sulfathiazole-protein derivatives The spleen cells of one of the mice were fused with myeloma cells to produce hybridomas of which the supernatants were screened in an indirect ELISA (iELISA) for the presence of sulfathiazole antibodies. After cloning, pos. supernatants were tested in a competitive iELISA (ciELISA) for inhibition with 18 sulfonamides. This resulted in four different mAbs (all IgG1 kappa light chain) which recognized several sulfonamides. By use of the best monoclonal (27G3) and an optimized ciELISA protocol, eight structurally different sulfonamides showed 50% inhibition at concentrations less than 100 ng ml-1 or 5 ng/well. However, other relevant sulfonamides (such as sulfadimidine, sulfatroxazole and sulfachloropyrazine) were detected at a high level only with this mAb. This means that the ciELISA (with the best Mab) showed a broad specificity for sulfonamides but the sensitivity towards the different sulfonamides varied too much to call it a generic sulfonamide ELISA.

Food and Agricultural Immunology published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C6H8N2O2S, Application of Methyl 2-(2-aminothiazol-4-yl)acetate.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Girard, M. L.’s team published research in Bulletin de la Societe Chimique de France in | CAS: 5053-24-7

Bulletin de la Societe Chimique de France published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Related Products of thiazole.

Girard, M. L. published the artcileStructural and reactional possibilities of thiazolidine derivatives. I. Addition, substitution, and hydrolysis, Related Products of thiazole, the publication is Bulletin de la Societe Chimique de France (1968), 3461-8, database is CAplus.

The reactivities of 2-imino-4-thiazolidinone (pseudothiohydantoin) (Ia), 2-4-thiazolidinedione (Ib), and 2-thio-2,4-thiazolidinedione (rhodanine) (Ic) were studied and some of their derivatives prepared by original or improved techniques and studied by thin layer chromatog., uv, ir, and polarography for structural determinations The hydrolytic ring cleavage was also investigated. E.g., addition reactions in the 2-position were attempted. A saturated solution of Ic in absolute EtOH was treated with saturated KOH in absolute EtOH to the exact equivalence point observed with a potentiometer to precipitate 90% K salt (II) of Ic. The K salt of the 2-thiohydantoin was obtained similarly (80%) in 8:2 EtOH-HCONMe2. II stirred in dilute EtOH during 2 hrs. with Me2SO4 gave yellow 2-(methylthio)-2-thiazolin-4-one, m. 170°. Stirring II in 90% EtOH with an equimol. amount of benzyl chloride at room temperature for 24 hrs. gave 2-(benzylthio)-2-thiazolin-4-one, yellowish brown, m. 65°. 2-(Acetylthio)-2-thiazolin-4-one (III), m. 250° (decomposition) was obtained by reaction of II in aqueous solution with an equimol. amount of ClCH2CO2H. Stirring ClCH2CO2K in dilute EtOH with an equimol. amount of II 1 hr. also gave III. Ic was converted into Ib by refluxing with 20% HNO3. 3-Substituted rhodanines (IIIa) were prepared via the dithiocarbamate by an improved method. ClCH2CO2K was added to a mixture of 24% aqueous NH3, CS2, and a primary amine, EtOH added, and the mixture acidified and refluxed to precipitate the following IIIa (3-substituent, m.p., and starting amine given): phenyl, 194°, aniline; benzyl, 85°, benzylamine; p-nitrophenyl, 144°, p-nitroaniline. 3-Methylrhodanine, 3-aminorhodanine and N-rhodanineacetic acid were prepared according to published methods. The following 5-substituted derivatives of Ib, Ic, and 3-phenyl-4-thiazolidinone (IV) were obtained by condensation with aldehydes (5-substituent, parent, m.p., and reactants given): benzylidene, Ic, 202°, Ic and BzH; benzylidene, 3 phenylrhodanine, 186°, BzH and 3 phenylrhodanine; p-nitrobenzylidene, Ic, 270°, p-nitrobenzaldehyde and Ic; p-methoxybenzylidene, Ic, 245°, Ic and anisaldehyde; cinnamylidene, Ic, 216°, Ic and cinnamaldehyde; cyclohexylidene, Ic, 173°, Ic and cyclohexanone; butylidene Ic, -, Ic and butyraldehyde; heptylidene, Ic, -, Ic and heptanal; benzylidene, 2,4-thiazolidinedione, 243°, BzH and Ib; benzylidene, 2 imino-4-thiazolidinone, 230° (decomposition), Ia and BzH; benzylidene, IV, 205°, BzH and IV. Electrochem. study of the hydrolytic cleavage of the rhodanine derivatives suggested the following preparation of α-mercaptocinnamic acid (VI): V (1 mole) dissolved in 200 ml. 2M Me4NOH solution, was kept 48 hrs. at room temperature and acidified with HCl to precipitate 80% yellow VI, m. 124° (ethanol).

Bulletin de la Societe Chimique de France published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Tian, Qiaopeng’s team published research in Journal of Hazardous Materials in 382 | CAS: 30931-67-0

Journal of Hazardous Materials published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C11H11NO2, Application In Synthesis of 30931-67-0.

Tian, Qiaopeng published the artcileCharacterization of a robust cold-adapted and thermostable laccase from Pycnoporus sp. SYBC-L10 with a strong ability for the degradation of tetracycline and oxytetracycline by laccase-mediated oxidation, Application In Synthesis of 30931-67-0, the publication is Journal of Hazardous Materials (2020), 121084, database is CAplus and MEDLINE.

A native laccase (Lac-Q) with robust cold-adapted and thermostable characteristics from the white-rot fungus Pycnoporus sp. SYBC-L10 was purified, characterized, and used in antibiotic treatments. Degradation experiments revealed that Lac-Q at 10.0 U mL-1 coupled with 1.0 mmol L-1 ABTS could degrade 100% of the tetracycline or oxytetracycline (50 mg L-1) within 5 min with a static incubation at 0 °C (pH 6.0). The presence of the Mn2+ ion inhibited the removal rate of tetracycline and oxytetracycline by the Lac-Q-ABTS system, and the presence of Al3+, Cu2+, and Fe3+ accelerated the removal rate of tetracycline and oxytetracycline by the Lac-Q-ABTS system. Furthermore, seven transformation products of oxytetracycline (namely TP 445, TP 431, TP 413, TP 399, TP 381, TP 367, and TP 351) were identified during the Lac-Q-mediated oxidation process by using UPLC-MS/MS. A possible degradation pathway including deamination, demethylation, and dehydration was proposed. Furthermore, the growth inhibition of Bacillus altitudinis SYBC hb4 and E. coli by tetracycline antibiotics revealed that the antimicrobial activity was significantly reduced after treatment with the Lac-Q-ABTS system. Finally, seven transformation products of oxytetracycline (namely TP 445, TP 431, TP 413, TP 399, TP 381, TP 367, and TP 351) were identified during the Lac-Q-mediated oxidation process by using UPLC-MS/MS. A possible degradation pathway including deamination, demethylation, and dehydration was proposed. These results suggest that the Lac-Q-ABTS system shows a great potential for the treatment of antibiotic wastewater containing different metal ions at various temperatures

Journal of Hazardous Materials published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C11H11NO2, Application In Synthesis of 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Etse, Koffi Senam’s team published research in ACS Chemical Neuroscience in 12 | CAS: 1204572-55-3

ACS Chemical Neuroscience published new progress about 1204572-55-3. 1204572-55-3 belongs to thiazole, auxiliary class Neuronal Signaling,GluR, name is 4-Cyclopropyl-7-fluoro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide, and the molecular formula is C10H11FN2O2S, Quality Control of 1204572-55-3.

Etse, Koffi Senam published the artcileDevelopment of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors, Quality Control of 1204572-55-3, the publication is ACS Chemical Neuroscience (2021), 12(14), 2679-2692, database is CAplus and MEDLINE.

On the basis of the activity of 1,2,4-benzothiadiazine 1,1-dioxides as pos. allosteric modulators of AMPA receptors, thiochroman 1,1-dioxides were designed applying the isosteric replacement concept. The new compounds expressed strong modulatory activity on AMPA receptors in vitro, although lower than their corresponding benzothiadiazine analogs. The pharmacokinetic profile of three thiochroman 1,1-dioxides (12a, 12b, 12e) was examined in vivo after oral administration, showing that these compounds freely cross the blood-brain barrier. Structural anal. was achieved using X-ray crystallog. after cocrystn. of the racemic compound 12b in complex with the ligand-binding domain of GluA2 (L504Y/N775S). Interestingly, both enantiomers of 12b were found to interact with the GluA2 dimer interface, almost identically to its benzothiadiazine analog, BPAM344 (4). The interactions of the two enantiomers ((R)-12b (I) and (S)-12b (II)) in the cocrystal were further analyzed (mapping Hirshfeld surfaces and 2D fingerprint) and compared to those of 4. Taken together, these data explain the lower affinity on AMPA receptors of thiochroman 1,1-dioxides compared to their corresponding 1,2,4-benzothiadiazine 1,1-dioxides.

ACS Chemical Neuroscience published new progress about 1204572-55-3. 1204572-55-3 belongs to thiazole, auxiliary class Neuronal Signaling,GluR, name is 4-Cyclopropyl-7-fluoro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide, and the molecular formula is C10H11FN2O2S, Quality Control of 1204572-55-3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Hodgson, Herbert H.’s team published research in Journal of the Chemical Society in | CAS: 1753-29-3

Journal of the Chemical Society published new progress about 1753-29-3. 1753-29-3 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Amine, name is Benzo[d][1,2,3]thiadiazol-5-amine, and the molecular formula is C6H5N3S, Application of Benzo[d][1,2,3]thiadiazol-5-amine.

Hodgson, Herbert H. published the artcileSome derivatives of benz-1-thia-2,3-diazole, the nature of the thiadiazole ring, and a note on the thiolation of 2-chloro-5-nitroaniline, Application of Benzo[d][1,2,3]thiadiazol-5-amine, the publication is Journal of the Chemical Society (1948), 870-4, database is CAplus.

2,5-Cl(O2N)C6H3NH2 (I) results in about 45% yield on treatment of 20.25 g. 2,4-(O2N)2C6H3Cl in 40 cc. boiling AcOH with 57 g. SnCl2 and distillation with steam; an equal quantity of 4,3-Cl(O2N)C6H3NH2 is nonvolatile with steam. I (17.5 g.) in 250 cc. boiling EtOH, treated gradually with 36 g. Na2S.9H2O and 12.6 g. NaHCO3 in 100 cc. H2O, the mixture heated 1 h. on the water bath, treated with 20 cc. 20% NaOH, added to 750 cc. ice and H2O, and 7 g. NaNO2 added to the filtrate, which was poured into a mixture of 25 cc. concentrated H2SO4 and 250 g. ice, gives 97% 5-nitrobenzothiadiazole (II), m. 143-5°, sublimes at 80-100°/atm. pressure, volatility with steam about 1 g./l.; II in Me2CO, treated with a drop aqueous NaOH, gives a violet color which is discharged by acid and restored by alkali; on standing the color slowly changes to brown. I. (1.725 g.) in 6 cc. boiling EtOH, treated with 1.8 g. Na2S.9H2O and 0.36 g. S in 2 cc. H2O, the mixture heated 1 h. on the steam bath, and treated as above, gives 1.3 g. impure II. The above alk. mixture, shaken with 20% aqueous NaOH and Me2SO4, gives 4,2-O2N(H2N)C6H3SMe, m. 105° (Ac derivative, pale lemon-yellow, m. 157°); (2-methylmercapto-5-nitro-2-phenylazo)-2-naphthol, scarlet, m. 236°. A solution of 4,2-O2N(H2N)C6H3SNa, shaken at room temperature with Ac2O, gives 4-nitro-2-(acetamidomercapto)phenyl acetate, pale cream, m. 150°. I (1.725 g.) in 96 cc. hot EtOH, treated with 0.36 g. S and 1.8 g. Na2S.9H2O in 2 cc. H2O and the mixture refluxed 5 h., gives [4,2-O2N(H2N)C6H3]2S, m. 218°. Reduction of 0.45 g. II in 20 cc. hot aqueous NaOH with 2 g. Na2S2O4 gives 0.15 g. 5-aminobenzothiadiazole (III), yellow, m. 95°; reduction of 0.02 g.-mol. II with 0.24 g.-mol. Fe powder in 1 cc. H2SO4, 30 cc. H2O, and 100 cc. EtOH (refluxed 3 h.) gives 82% III; diazotization of the filtrate and coupling with 2-naphthol gave 17% benzothiadiazol-5-ylazo-2-naphthol, bright red, m. 209°; H2SO4 gives a reddish pink color, changing to pale pink on dilution with H2O. III, through the diazo reaction, yields 5-bromobenzothiadiazole, m. 106°, and the 5-I derivative, m. 103° (solubility of the latter in H2O at room temperature 0.3 g./l.). The yields of thiol and monosulfide from I and Na2S, Na2S2, Na2S2.5, and NaSH are given; Na2S2O3 does not react with I. A cyclic structure is preferred for the thiadiazole ring in contrast to the quinonoid resonance structure of the analogous diazoöxides.

Journal of the Chemical Society published new progress about 1753-29-3. 1753-29-3 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Amine, name is Benzo[d][1,2,3]thiadiazol-5-amine, and the molecular formula is C6H5N3S, Application of Benzo[d][1,2,3]thiadiazol-5-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Yamano, Tomoyoshi’s team published research in Journal of Experimental Medicine in 216 | CAS: 95-24-9

Journal of Experimental Medicine published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C8H11BO2, Computed Properties of 95-24-9.

Yamano, Tomoyoshi published the artcileAire-expressing ILC3-like cells in the lymph node display potent APC features, Computed Properties of 95-24-9, the publication is Journal of Experimental Medicine (2019), 216(5), 1027-1037, database is CAplus and MEDLINE.

The autoimmune regulator (Aire) serves an essential function for T cell tolerance by promoting the “promiscuous” expression of tissue antigens in thymic epithelial cells. Aire is also detected in rare cells in peripheral lymphoid organs, but the identity of these cells is poorly understood. Here, we report that Aire protein-expressing cells in lymph nodes exhibit typical group 3 innate lymphoid cell (ILC3) characteristics such as lymphoid morphol., absence of “classical” hematopoietic lineage markers, and dependence on RORγt. Aire+ cells are more frequent among lineage-neg. RORγt+ cells of peripheral lymph nodes as compared with mucosa-draining lymph nodes, display a unique Aire-dependent transcriptional signature, express high surface levels of MHCII and costimulatory mols., and efficiently present an endogenously expressed model antigen to CD4+ T cells. These findings define a novel type of ILC3-like cells with potent APC features, suggesting that these cells serve a function in the control of T cell responses.

Journal of Experimental Medicine published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C8H11BO2, Computed Properties of 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Pajnik, Jelena’s team published research in Macromolecular Materials and Engineering in 307 | CAS: 30931-67-0

Macromolecular Materials and Engineering published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Category: thiazole.

Pajnik, Jelena published the artcileZeolite/Chitosan/Gelatin Films: Preparation, Supercritical CO2 Processing, Characterization, and Bioactivity, Category: thiazole, the publication is Macromolecular Materials and Engineering (2022), 307(8), 2200009, database is CAplus.

Chitosan/gelatin and chitosan/gelatin/zeolite films prepared by solvent casting method are impregnated with a mixture of thymol and carvacrol using a green solvent, supercritical carbon dioxide at 35 °C and 30 MPa, during 18 h. Proposed method enables preparation of biocompatible and biodegradable blends with strong antioxidant and antibacterial activity, whereby amounts of loaded thymol/carvacrol (TC) mixture are in the range from 3.3% to 6%. After initial burst release, both types of films exhibit gradual release of bioactive compounds, with around 72% and 96% of impregnated TC mixture released in water and phosphate buffered saline solution (pH 7.4) during tested period of 10 days, resp. Results of water vapor transmission rate (>76 g m-2 day-1) confirm that prepared composites are suitable for wound dressing application. Thermal anal. shows superior properties of prepared TC loaded films compared to control samples. In addition, mech. and structural properties, as well as solubility and swelling behavior of the obtained films are investigated in detail.

Macromolecular Materials and Engineering published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Song, Jung Min’s team published research in Experimental Neurology in 252 | CAS: 92-36-4

Experimental Neurology published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C4H10Br2CoO2, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Song, Jung Min published the artcileA tetra(ethylene glycol) derivative of benzothiazole aniline ameliorates dendritic spine density and cognitive function in a mouse model of Alzheimer’s disease, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Experimental Neurology (2014), 105-113, database is CAplus and MEDLINE.

We recently reported that the tetra(ethylene glycol) derivative of benzothiazole aniline, BTA-EG4, acts as an amyloid-binding small mol. that promotes dendritic spine d. and cognitive function in wild-type mice. This raised the possibility that BTA-EG4 may benefit the functional decline seen in Alzheimer’s disease (AD). In the present study, we directly tested whether BTA-EG4 improves dendritic spine d. and cognitive function in a well-established mouse model of AD carrying mutations in APP, PS1 and tau (APPswe;PS1M146V;tauP301L, 3xTg AD mice). We found that daily injections of BTA-EG4 for 2 wk improved dendritic spine d. and cognitive function of 3xTg AD mice in an age-dependent manner. Specifically, BTA-EG4 promoted both dendritic spine d. and morphol. alterations in cortical layers II/III and in the hippocampus at 6-10 mo of age compared to vehicle-injected mice. However, at 13-16 mo of age, only cortical spine d. was improved without changes in spine morphol. The changes in dendritic spine d. correlated with Ras activity, such that 6-10 mo old BTA-EG4 injected 3xTg AD mice had increased Ras activity in the cortex and hippocampus, while 13-16 mo old mice only trended toward an increase in Ras activity in the cortex. Finally, BTA-EG4 injected 3xTg AD mice at 6-10 mo of age showed improved learning and memory; however, only minimal improvement was observed at 13-16 mo of age. This behavioral improvement corresponds to a decrease in soluble Aβ 40 levels. Taken together, these findings suggest that BTA-EG4 may be beneficial in ameliorating the synaptic loss seen in early AD.

Experimental Neurology published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C4H10Br2CoO2, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica