Day: November 21, 2022

Shetgar, Sanjay Shesha published the artcileDevelopment and validation of UPLC method for quantitative estimation of related impurities in tizanidine hydrochloride tablets, Quality Control of 30536-19-7, the publication is Journal of Applied Pharmaceutical Science (2021), 11(8), 043-053, database is CAplus.

Tizanidine hydrochloride is known to have several related impurities depending on the manufacturing process. There is no published ultra-performance liquid chromatog. (UPLC) method which can simultaneously quantify these impurities. The current work is to design, develop, and validate an UPLC method for simultaneous estimation of all known impurities. Forced degradation studies performed on tablet formulation did not show any purity flags. To achieve sensitive and optimal separation of all the six impurities from the main moiety of Tizanidine, gradient UPLC system with ethylene bridged hybrid C8 column, 230 nm UV detection provided an optimum separation The developed method was quick, with all six impurities eluting within 11 min. Low level of impurities could be quantified with limit of detection in the range 0.008%-0.028% and limit of quantitation in the range 0.037%-0.057%. Recoveries of all spiked impurities in Tizanidine hydrochloride were well within the range of 85%-115%. Thus, the developed UPLC method is sensitive, fast, and provides precise and accurate quantitation of all known impurities in Tizanidine hydrochloride tablets. The developed method is very useful for quant. estimation of impurities in Tizanidine hydrochloride tablets in routine quality control as well as stability monitoring programs. The method can easily be extended to quant. cleaning residue determination in pharmaceutical industry.

Journal of Applied Pharmaceutical Science published new progress about 30536-19-7. 30536-19-7 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Chloride,Amine, name is 5-Chlorobenzo[c][1,2,5]thiadiazol-4-amine, and the molecular formula is C42H63O3P, Quality Control of 30536-19-7.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Singh, Manjula published the artcileVisible-light photoredox catalytic approach for the direct synthesis of 2-aminobenzothiazoles from anilines, Application of 6-Chlorobenzothiazol-2-ylamine, the publication is Tetrahedron Letters (2020), 61(13), 151700, database is CAplus.

A novel, highly efficient and convenient approach for the visible-light-promoted direct synthesis of 2-aminobenzothiazoles from anilines and ammonium thiocyanate is presented. The reaction involves addition/cyclization cascade of SCN radical and anilines under photoredox catalysis with Ru(bpy)3Cl₂. The salient features of the protocol include the utilization of atm. oxygen and visible light as clean, inexpensive and sustainable resources at room temperature

Tetrahedron Letters published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C8H14O2, Application of 6-Chlorobenzothiazol-2-ylamine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Akhil published the artcileComparative evaluation of laccase mediated oxidized and unoxidized lignin of sugarcane bagasse for the synthesis of lignin-based formaldehyde resin, HPLC of Formula: 30931-67-0, the publication is Industrial Crops and Products (2020), 112385, database is CAplus.

Pretreatment using dilute acid is one of the strategies employed in a lignocellulosic biorefinery. The current study deals with the isolation, characterization, and oxidation of lignin from the enzymic residue of acid pre-treated sugarcane bagasse. The study also focused on evaluating the reactivity of Laccase mediated oxidized lignin with the non-oxidized one for the preparation of lignin-based formaldehyde (LF) resin. In the current study, 100% phenolic lignin was utilized for the synthesis of LF resin. Three different approaches (Alk. hydrolysis, mild acidolysis & organosolv) have been employed to evaluate the effect of isolation method on the physicochem. properties of lignin. The isolation method had a bearing on the properties of lignin and its reactivity towards formaldehyde for the synthesis of LF resin. Alkali and organosolv lignin were found as promising candidates for the preparation of LF resin. Oxidized lignin exhibited better reactivity than the non-oxidized one.

Industrial Crops and Products published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, HPLC of Formula: 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Joshi, Medha published the artcilePoly (urethane-urea)-epoxy glass fiber reinforced composites, Quality Control of 95-24-9, the publication is International Journal of ChemTech Research (2021), 14(1), 199-205, database is CAplus.

A series of poly(urethane-urea)s (PUU)s were synthesized using toluene 2, 4- diisocyanate, various 2-amino benzothiazoles and 3-amino phenol. All the PUUs were characterized by elemental anal., spectral studies, number average mol. weight (Mn) and thermogravimetry. Further reaction of PUUs was carried out with an epoxy resin (i.e.DGEBA). The curing study of prepared resins was monitored by DSC. Based on DSC thermograms glass fiber reinforced composites have been laminated and characterized by chem., mech. and elec. properties. The unreinforced cured resins were subjected to thermogravimetric anal.

International Journal of ChemTech Research published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Quality Control of 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Liu, Jingbao published the artcileDesign, synthesis, and biological evaluation of 2-substituted ethenesulfonic acid ester derivatives as selective PTP1B inhibitors, Name: 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Pharmazie (2015), 70(7), 446-451, database is CAplus and MEDLINE.

Fifteen 2-substituted ethenesulfonic acid ester derivatives were designed, synthesized, and evaluated for the inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) and T-Cell protein tyrosine phosphatase (TCPTP). The structural activity relationship (SAR) of these compounds were discussed to clarify the impact of the linker and the optimized tail on the inhibitory activity of PTP1B and selectivity over TCPTP. Most of the compounds exhibited excellent inhibitory activities against PTP1B with IC₅₀ values of 1.5-8.9 μM. SAR anal. revealed that the substituents at the hydrophobic tail significantly alter the inhibitory activity against PTP1B and selectivity over TCPTP, e.g. compound Ethyl-2-(4-(3-(4-(2-chlorophenyl)thiazol-2-ylamino)propoxy)phenyl)ethenesulfonate showed excellent inhibitory activity to PTP1B with IC₅₀ = 7.8 μM, and ∼6-fold selectivity over TCPTP. Combined with our previous findings, that the linker length and the substituted hydrophobic tail had decisive influence on the PTP1B inhibitory activity and selectivity was confirmed.

Pharmazie published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Name: 4-(Naphthalen-1-yl)thiazol-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Oegretir, Cemil published the artcileDetermination and Evaluation of Acid Dissociation Constants of Some Substituted 2-Aminobenzothiazole Derivatives, Safety of 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Journal of Chemical & Engineering Data (2008), 53(2), 422-426, database is CAplus.

The acid dissociation constants of some 4- and/or 6-substituted 2-aminobenzothiazole and 4-substituted thiazole derivatives were determined spectroscopically. With the exception of a few, the first protonation was found to occur on the amino group. In some mols. where prototropic tautomerism is possible, a change-over in the protonation mechanism was observed The first protonation under these circumstances was found to occur on the imino nitrogen atom. The second protonation takes place on the thiazole ring nitrogen atom.

Journal of Chemical & Engineering Data published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Safety of 4-(Naphthalen-1-yl)thiazol-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Hanke, Thomas published the artcileAminothiazole-Featured Pirinixic Acid Derivatives As Dual 5-Lipoxygenase and Microsomal Prostaglandin E₂ Synthase-1 Inhibitors with Improved Potency and Efficiency in Vivo, Related Products of thiazole, the publication is Journal of Medicinal Chemistry (2013), 56(22), 9031-9044, database is CAplus and MEDLINE.

Dual inhibition of microsomal prostaglandin E₂ synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) is currently pursued as potential pharmacol. strategy for treatment of inflammation and cancer. Here we present a series of 26 novel 2-aminothiazole-featured pirinixic acid derivatives as dual 5-LO/mPGES-1 inhibitors with improved potency (exemplified by compound 2-[(4-chloro-6-{[4-(naphthalen-2-yl)-1,3-thiazol-2-yl]-amino}-pyrimidin-2-yl)-sulfanyl]-octanoic acid (I) with IC₅₀ = 0.3 and 0.4 μM, resp.) and bioactivity in vivo. Computational anal. presumes binding sites of I at the tip of the 5-LO catalytic domain and within a subpocket of the mPGES-1 active site. Compound I (10 μM) hardly suppressed cyclooxygenase (COX)-1/2 activities, failed to inhibit 12/15-LOs, and is devoid of radical scavenger properties. Finally, compound I reduced vascular permeability and inflammatory cell infiltration in a zymosan-induced mouse peritonitis model accompanied by impaired levels of cysteinyl-leukotrienes and prostaglandin E₂. Together, 2-aminothiazole-featured pirinixic acids represent potent dual 5-LO/mPGES-1 inhibitors with an attractive pharmacol. profile as anti-inflammatory drugs.

Journal of Medicinal Chemistry published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Brandsma, L. published the artcileAn efficient synthesis of 1,3-thiazole, Recommanded Product: 2-(Methylthio)thiazole, the publication is Synthesis (1985), 948-9, database is CAplus.

The cyclocondensation of Me dithiocarbamate with ClCH₂CHO in aqueous ethanol afforded thiazole I (R = SMe). I (R = SMe) was demethylsulfenylated to I (R = H) by reaction with lithium in liquid ammonia followed by hydrolysis with aqueous ammonium chloride.

Synthesis published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Recommanded Product: 2-(Methylthio)thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Pandey, Deepshikha published the artcileBioremoval of toxic malachite green from water through simultaneous decolorization and degradation using laccase immobilized biochar, Application of Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is Chemosphere (2022), 134126, database is CAplus and MEDLINE.

In this study, decolorization and degradation of malachite green dye was studied using the laccase immobilized pine needle biochar. Successful immobilization of biochar was achieved by adsorption and confirmed through SEM and energy dispersive X-ray anal. (SEM-EDX), Fourier transform IR spectroscopy (FTIR). High laccase binding of 64.4 U/g and high immobilization yield of 78.1% was achieved using 4U of enzyme at pH3 and temperature 30 °C. The immobilized laccase retained >50% relative activity in the pH range 2-7, >45% relative activity at 65 °C and >55% relative activity at 4 °C for 4 wk. The re-usability of immobilized enzyme was checked with 2, 2′-azino-bis 3-ethylbenzothiazoline-6-sulfonic acid (ABTS) substrate and enzyme retained 53% of its activity after 6 cycles. Immobilized laccase was used for the degradation and decolorization of azo dye malachite green in aqueous solution More than 85% removal of malachite green dye (50 mg/L) was observed within 5 h. FTIR and high performance liquid chromatog. (HPLC) anal. clearly indicated the breakdown of dye and presence of metabolites (leuco malachite green, methanone, [4-(di-Me amino)pheny]phenyl and 3-dimethyl-Ph amine) in gas chromatog.-mass spectrometry (GC-MS) anal. confirmed the dye degradation Phytotoxicity anal. indicated that the enzymic degradation resulted in lesser toxic metabolites than the original dye. Thus, laccase immobilized biochar can be used as an efficient biocatalytic agent to remove dye from water.

Chemosphere published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Application of Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Nath, J. P. published the artcileSynthesis of some 7-substituted 8-hydroxyquinoline derivatives of thiazoles and oxazoles as potential pesticides, Quality Control of 56503-96-9, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1981), 20B(7), 606-7, database is CAplus.

Mannich reaction of 8-hydroxyquinoline with PhCHO and I (R = H, Cl, Br; R¹ = Ph, 4-ClC₆H₄, 4-BrC₆H₄, 4-HOC₆H₄, 4-MeO(C₆H₄, 3-O₂NC₆H₄, 4-O₂NC₆H₄, 4-MeC₆H₄, α-,β-naphthyl; X = O, S) gave the title compounds (II). II showed bactericidal and fungicidal activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Quality Control of 56503-96-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica