Day: November 21, 2022

Chehab, Rana published the artcileDevelopment of an automated system for the analysis of inorganic chloramines in swimming pools via multi-syringe chromatography and photometric detection with ABTS, Quality Control of 30931-67-0, the publication is Talanta (2020), 120322, database is CAplus and MEDLINE.

Inorganic chloramines are disinfection byproducts resulting from the unwanted reaction between chlorine used as disinfectant in swimming pools and nitrogenous compounds brought by bathers. This parameter (total chloramines or combined chlorine) is currently measured on site by a colorimetric method that does not allow to measure only inorganic chloramines. In this paper, a multi-syringe chromatog. system combined with a post column derivatization is applied for the first time for the specific detection of the three individual inorganic chloramines (monochloramine, dichloramine and trichloramine). These latter ones are separated using a low-pressure monolithic C18 column, and sep. detected after a post-column reaction with the chromogenic reagent ABTS (2,2′-azino-bis-(3-ethyl-benzothiazoline)-6-sulfonic acid-diammonium salt). Development of two ABTS reagents provides discrimination of chlorine and monochloramine that are not separated on the column. Optimization of the exptl. conditions enables determination of inorganic chloramines with very good detection limits (around 10 μg eq.Cl₂ L^-1) without interferences from other chlorinated compounds such as organic chloramines or free available chlorine. The validation of the whole procedure has been successfully applied to real swimming pools samples.

Talanta published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Quality Control of 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Chau, Chi-Fai published the artcileCommercialized Sesame Oil Analysis: Quality Characterization and Oxidative Stability of Blended Sesame Oil, Quality Control of 30931-67-0, the publication is ACS Food Science & Technology (2021), 1(7), 1222-1227, database is CAplus.

Sesame oil is a high quality edible oil in Asia with unique flavor and aroma. However, sesame oil is more expensive than soybean oil; therefore, both sesame and soybean oil are blended to reduce costs. In this study, we performed quality characterization anal. of sesame oil (SeO) and sesame oil blended with soybean oil (B-SeO). In our results, fatty acid composition was not significantly different; however, acid, anisidine, peroxide, and total oxidation values of B-SeO were lower than SeO; B-SeO was found to meet CODEX quality standards for cold-pressed oil; 1,1-diphenyl-2-trinitrophenylhydrazine, 2,2-diazo-bis(3-ethyl-benzothiazole-6-sulfonic acid) diammonium salt scavenging capacity, and ferric reducing antioxidant power values of the SeO and B-SeO were in the following ranges 23.72-42.66%, 26.4-29.62%, and 0.44-0.57%, resp.; by following the Arrhenius equation, activation energies for oxidative stability of the two products ranged between 95.51 and 120.34 kJ/mol; antioxidant activities of these oil products were correlated with Maillard reaction products. In conclusion, it was determined that blending sesame oil with soybean oil improved the quality characterization and increased the applications and uses of sesame oil products.

ACS Food Science & Technology published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Quality Control of 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Kim, Mi Kyoung published the artcile3D-QSAR of PET agents for imaging β-amyloid in Alzheimer’s disease, Category: thiazole, the publication is Bulletin of the Korean Chemical Society (2007), 28(7), 1231-1234, database is CAplus.

The accumulation of excess senile plaques (β-amyloid, Aβ-plaques) in the brain is strongly associated with the pathogenesis of Alzheimer’s disease (AD). While there are no definitive treatments available to affect a cure of AD, much recent interest has been given to the development of antiamyloid therapies aimed at halting and reversing Aβ-deposition and, thus, monitoring of the therapeutic efficacy would greatly benefit from methods for the in vivo detection and quantification of Aβ-deposits in the brain. A 3D-QSAR model was constructed with several PET ligands such as Thioflavin-T analogs and stilbene derivatives using CoMFA (Comparative Mol. Field Anal.) and CoMSIA (Comparative Mol. Similarity Indexes Anal.). The 3D-QSAR model could be applied to predict binding affinity of the structurally related compounds against Aβ-plaques.

Bulletin of the Korean Chemical Society published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Cho, Eunbee published the artcileA Single-Benzene-Based Fluorophore: Optical Waveguiding in the Crystal Form, Name: N,N-Dimethyl-N’-(3-thioxo-3H-1,2,4-dithiazol-5-yl)formimidamide, the publication is ChemPlusChem (2019), 84(8), 1130-1134, database is CAplus and MEDLINE.

A single-benzene-based, blue-emissive di-Et 2,5-dihydroxyterephthalate (DDT) was prepared by Fischer esterification of 2,5-dihydroxyterephthalic acid (DHT) and ethanol. The strong fluorescence in both the solution and the solid state from such a simple framework stemmed from the push-pull structure of the electron-donating hydroxy groups and the accepting carbonyl groups, as well as structural planarity from intramol. hydrogen bonds. The strong intermol. hydrogen bonds enabled DDT to crystallize easily. The color CCD imaging technique showed efficient 1D optical waveguiding with a large optical loss coefficient of 0.15 dB/μm. DDT has potential application in optical sensors, photonic devices, and optoelectronic communication, because of its highly ordered structure and light-emitting ability.

ChemPlusChem published new progress about 1192027-04-5. 1192027-04-5 belongs to thiazole, auxiliary class Other Aliphatic Heterocyclic,Amine, name is N,N-Dimethyl-N’-(3-thioxo-3H-1,2,4-dithiazol-5-yl)formimidamide, and the molecular formula is C5H7N3S3, Name: N,N-Dimethyl-N’-(3-thioxo-3H-1,2,4-dithiazol-5-yl)formimidamide.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Vladimirov, V. G. published the artcileMethemoglobin-forming effect and its role in the mechanism of action of some radioprotectants of the 2,1,3-benzothiadiazole class, Related Products of thiazole, the publication is Radiobiologiya (1977), 17(6), 828-33, database is CAplus and MEDLINE.

Thirty min after i.p. administration to mice of radioprotective doses of benzo-2,1,3-thiadiazole(I) derivatives, the metHb level in blood did not exceed 5%. After administration of a toxic dose of 4-aminobenzo-2,1,3-thiadiazole [767-64-6] (150 mg/kg), metHb in mouse blood reached 14%. After oral administration of 4-aminobenzo-2,1,3-thiadiazole to dogs, metHb of blood reached almost 50%. By using substances preventing oxidation of Hb to metHb (isonicotinic acid hydrazide and 2-methoxy-9-phenazine sulfate), it was shown that metHb formed in mouse blood did not play a leading role in the manifestation of radioprotective and toxic properties of 4-aminobenzo-2,1,3-thiadiazole.

Radiobiologiya published new progress about 1753-29-3. 1753-29-3 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Amine, name is Benzo[d][1,2,3]thiadiazol-5-amine, and the molecular formula is C4H10Br2CoO2, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Ahmed, Owais published the artcileSolvent-dependent regio- and stereo-selective reactions of 3-formylchromones with 2-aminobenzothiazoles and transacetalization efficiency of the product 3-((benzo[d]thiazol-2-ylimino)butyl)-4H-chromen-4-one, Formula: C7H5ClN2S, the publication is RSC Advances (2019), 9(36), 20573-20581, database is CAplus and MEDLINE.

Using 2-propanol as the solvent, 3-formylchromones I (R = H, 6-Cl, 6-Br, 6-OH, 6-Cl-8-Br) and 2-aminobenzothiazoles II [R¹ = 4-Cl, 6-Br, 4,6-(F₂), etc.] formed corresponding imines, (Z)-III while 1° and 2°-alcs. R²OH [R² = CH₃, CH(CH₃)₂, cyclohexyl, etc.] formed the corresponding 2-alkoxy-3-enamines IV with selectivity for the Z-isomer. Changing the substrates with similar mols. such as 3-formylchromone I with quinoline-, quinolone- and indole-3-carbaldehydes, e.g., 1,4-dihydro-4-oxoquinoline-3-carbaldehyde sometimes resulted in the formation of the corresponding imines, e.g., 3-((benzo[d]thiazol-2-ylimino)methyl)quinolin-4(1H)-one, whereas replacing 2-aminobenzothiazole with amides R³C(O)NH₂ (R³ = H, Me, Ph) resulted in the formation of acetals V. Considering the effect of the solvent, replacing alcs. with the aprotic solvents THF and CH₂Cl₂ resulted in the formation of imines and enamines, which are the characteristic reactions of 2-propanol and other 1° and 2°-alcs., resp. 2-Alkoxy-3-enamines were found to undergo transacetalization with both short and long chain alcs. The novelty of these reactions is that they did not require an external catalyst, all the reactions were performed at the same temperature, and purification was achieved by filtration. The transacetalization has been performed as a new concept, which has not been reported to date. In contrast, other similar reactions, such as transalkoxylation, transalkylation, and transetherification, are performed on a com. scale using expensive catalysts such as Otera’s catalyst. The highly sensitive nature of 3-formylchromones towards variations in the substrates and solvents to form different products and the reason behind the selective formation of the Z-isomer of 2-alkoxy-3-enamines and its transacetalization efficiency need further studies to understand the reaction mechanism and possibly other factors such as solvent effects.

RSC Advances published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Formula: C7H5ClN2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Jiang, Fengchao published the artcileThe design and synthesis of 2-aminothiazole derivatives and their inhibitory activity on apoptosis, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Yaoxue Xuebao (2006), 41(8), 727-734, database is CAplus and MEDLINE.

The objective of this study is to investigate the inhibitory effect of 2-aminothiazole derivatives on Neuro-cell apoptosis and QSAR. The 2-aminothiazole derivatives were designed and synthesized based on the lead compound of PFT-α, the protective action of the compounds against and their inhibitory action on PC12 cell apoptosis induced by H₂O₂ were determined by MTT method and FCM method. The QSAR equation was obtained from Cerius²-QSAR⁺ module. Eleven novel 2-aminothiazole Schiff base compounds(II) have been designed and synthesized. The structure of the final compound were characterized by IR, MS, ¹HNMR, ¹³ CNMR. Their protective action against and the inhibitory action on PC12 cell apoptosis induced by H₂O₂ were found in this experiment The optimal QSAR equation obtained from the Cerius²-QSAR⁺ module by using log (1 /EC₅₀) with corresponding descriptors is Activity = 6.94768 – 0.08872*”LUMO”- 0.043018*”Alogp98″- 0.128752*”Rad0fGration”+ 0.018246*”Dipole-mag”. The correlation statistics parameters of the above equation are as follows: r² = 0.970, F-test = 49.149, r = 0.985 and Lse = 0.001. The 2-aminothiazole derivatives exhibited certain activity in inhibiting PC12 cell apoptosis induced by H₂O₂. Some compounds have the dual activities, the protective action against and inhibitory action on PC12 cell apoptosis induced by H₂O₂. The QSAR equation indicated that it is favorable for enhance the activity of 2-aminothiazole derivatives by the reduction of “radius of gyration” and the energy of “LUMO”of the compounds

Yaoxue Xuebao published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Hu, Wan-Ping published the artcileSynthesis, and biological evaluation of 2-(4-aminophenyl)benzothiazole derivatives as photosensitizing agents, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Bioorganic & Medicinal Chemistry (2010), 18(16), 6197-6207, database is CAplus and MEDLINE.

Photodynamic therapy (PDT) employing exogenous photosensitizers is currently being approved for treatment of basal cell carcinoma (BCC). 2-(4-Aminophenyl)benzothiazoles (6) consist of chromophoric structure and absorb light in the UVA (315-400 nm). These results encouraged us to design and synthesize a diversity of 2-phenylbenzothiazoles (6). Studies on the apoptotic mechanism involved in photosensitive effects induced by UVA-activated 6 in BCC cells are carried out in the present article. 6-UVA-treated cells displayed several features of apoptosis, including an increase in the sub-G1 population, a significantly increased annexin V binding, and activation of caspase-3. 6-UVA induced a decrease in mitochondrial membrane potential (Δψ _mt) and ATP via enhanced ROS generation and promoted phosphorylation of extracellular signal-regulated kinase (ERK) and p38 MAPK expression. These results suggest that 6-UVA elicits photosensitive effects in mitochondria processes which involve ERK and p38 activation, and ultimately lead to BCC cell apoptosis.

Bioorganic & Medicinal Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Zhang, Lei published the artcileDiscovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase, Category: thiazole, the publication is European Journal of Medicinal Chemistry (2012), 624-639, database is CAplus and MEDLINE.

Dual-target-directed agents simultaneously inhibiting glycogen phosphorylase (GP) and activating glucokinase (GK) could decelerate the inflow of glucose from glycogenolysis and accelerate the outflow of glucose in the liver, and therefore allow for better control over hyperglycemia in a synergetic manner. A series of hybrid compounds were designed by structure-assisted and ligand-based strategies. In vitro bioassays found two novel compounds I and II worthy of further optimization on balance of dual action to GP and GK. In addition, for single-target activity, two compounds exhibited more potent GP inhibitory activity and four compounds showed better GK activation than their corresponding references

European Journal of Medicinal Chemistry published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C14H10O4, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Bai, Shuya published the artcileSpindle and kinetochore-associated complex subunit 3 (SKA3) promotes stem cell-like properties of hepatocellular carcinoma cells through activating Notch signaling pathway, Application of 6-Chlorobenzothiazol-2-ylamine, the publication is Annals of Translational Medicine (2021), 9(17), 1361, database is CAplus and MEDLINE.

Cancer stemness contributes to hepatocellular carcinoma (HCC) initiation, metastasis, drug resistance, and recurrence. The spindle and kinetochore-associated (SKA) complex has been shown to be involved in tumor progression; however, its effects on cancer stem cell-like properties have not yet been examined This research sought to study each subunit of the SKA complex in HCC systematically. Bioinformatic analyses were carried out to examine the expression and clin. data of the SKA complex′s each subunit in HCC. The expression of the target genes was detected by quant. reverse transcription-polymerase chain reaction and Western blot assays. Clone formation and Transwell assays were performed to assess the proliferation and migration abilities of the SKA complex′s each subunit. Sphere formation assays and s.c. xenograft experiments were performed to investigate the effects of SKA complex subunit 3 (SKA3) on the self-renewal and tumorigenic abilities of HCC. Each subunit of the SKA complex was highly expressed in HCC, but only SKA complex subunit 1 (SKA1) and SKA3 were associated with the poor overall survival of HCC patients. Addnl., the HCC cells overexpressing SKA3 exhibited increased migration, invasion, proliferation, self-renewal, Sorafenib resistance and tumorigenic abilities. Notch signaling played a vital role in the process by which SKA3 promoted HCC stemness. SKA3 promotes HCC stem cell-like properties via the Notch signaling pathway. As SKA3 appears to act as a regulator of stemness in HCC, it might be a potential mol. target for HCC.

Annals of Translational Medicine published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Application of 6-Chlorobenzothiazol-2-ylamine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica