A novel insight into fluorescent sensor for patulin detection using thiol-terminated liposomes with encapsulated coumarin-6 as signal probe was written by Nie, Dongxia;Guo, Dakai;Huang, Qingwen;Guo, Wenbo;Wang, Jianhua;Zhao, Zhihui;Han, Zheng. And the article was included in Sensors and Actuators, B: Chemical in 2021.Recommanded Product: 38215-36-0 The following contents are mentioned in the article:
Nanocomposites of thiol-terminated liposomes encapsulating with coumarin-6 (CM6@Lip-SH) were successfully prepared via a simple thin-film dispersion method to construct a novel fluorescent sensor for selectively detecting trace amounts of patulin. Thiol group (-SH) was designed not only as a specific recognition element to capture patulin, but also as a convenient linker for the further separation of patulin-derivatized and un-derivatized CM6@Lip-SH by combination with magnetic NH2-Au@Fe3O4 nanoparticles. Liposomes primarily provided an effective platform with a large surface area for facilitated accommodation of large amounts of recognition element (-SH group) and fluorophore (coumarin-6). In such an assay protocol, a reliable link was established between the changes in fluorescent intensity (ΔF) from the nanocomposites of CM6@Lip-SH/NH2-Au@Fe3O4 and the concentrations of patulin in the range of 0.05-20 ng mL-1, with the correlation coefficient of 0.996. This approach also effectively eliminated the background interference from other mycotoxins and metal ions. Under the optimal conditions, the designed sensor displayed excellent performance for patulin anal., with an extremely low detection limit (0.033 ng mL-1), high recovery (96.2-107.6%) and excellent selectivity. Furthermore, the feasibility of its applications has also been demonstrated in the anal. of real juice samples, providing a novel tactics for rational design of a fluorescence assay, for point-of-care diagnostics of patulin, with great potential to be extended to other hazardous compounds by substitution of the recognition elements. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Recommanded Product: 38215-36-0).
3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 38215-36-0
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica