Pifithrin-μ modulates microglial activation and promotes histological recovery following spinal cord injury was written by Caponegro, Michael D.;Torres, Luisa F.;Rastegar, Cyrus;Rath, Nisha;Anderson, Maria E.;Robinson, John K.;Tsirka, Stella E.. And the article was included in CNS Neuroscience & Therapeutics in 2019.Computed Properties of C16H19BrN2OS The following contents are mentioned in the article:
Treatments immediately after spinal cord injury (SCI) are anticipated to decrease neuronal death, disruption of neuronal connections, demyelination, and inflammation, and to improve repair and functional recovery. Currently, little can be done to modify the acute phase, which extends to the first 48 h post-injury. Efforts to intervene have focused on the subsequent phases – secondary (days to weeks) and chronic (months to years) – to both promote healing, prevent further damage, and support patients suffering from SCI. We used a contusion model of SCI in female mice, and delivered a small mol. reagent during the early phase of injury. Histol. and behavioral outcomes were assessed and compared. We find that the reagent Pifithrin-μ (PFT-μ) acts early and directly on microglia in vitro, attenuating their activation. When administered during the acute phase of SCI, PFT-μ resulted in reduced lesion size during the initial inflammatory phase, and reduced the numbers of pro-inflammatory microglia and macrophages. Treatment with PFT-μ during the early stage of injury maintained a stable anti-inflammatory environment. Our results indicate that a small mol. reagent PFT-μ has sustained immunomodulatory effects following a single dose after injury. This study involved multiple reactions and reactants, such as 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2Computed Properties of C16H19BrN2OS).
2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Computed Properties of C16H19BrN2OS
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica