Liu, Da-Chuan et al. published their research in Molecules in 2016 | CAS: 14372-65-7

6-Butoxybenzo[d]thiazol-2-amine (cas: 14372-65-7) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Quality Control of 6-Butoxybenzo[d]thiazol-2-amine

Synthesis and biological evaluation of novel benzothiazole derivatives as potential anticonvulsant agents was written by Liu, Da-Chuan;Zhang, Hong-Jian;Jin, Chun-Mei;Quan, Zhe-Shan. And the article was included in Molecules in 2016.Quality Control of 6-Butoxybenzo[d]thiazol-2-amine The following contents are mentioned in the article:

New benzothiazoles with a mercapto-triazole and other heterocycle substituents I (R = Pr, benzyl, 3-trifluoromethylbenzyl, etc.; R1 = 1H-1,2,4-triazol-3-ylthio, 1H-1,2,4-triazol-1-yl, 3-amino-1H-1,2,4-triazol-1-yl, 1H-imidazol-1-yl, 1H-1,2,3,4-tetrazol-1-yl) were synthesized and evaluated for their anticonvulsant activity and neurotoxicity by using the maximal electroshock (MES), s.c. pentylenetetrazole (scPTZ), and rotarod neurotoxicity (TOX) tests. Among the compounds studied, compounds I (R = 3-fluorobenzyl, 4-fluorobenzyl; R1 = 1H-1,2,4-triazol-3-ylthio) were the most potent, with an ED50 value of 50.8 mg/kg and 54.8 mg/kg in the MES test and 76.0 mg/kg and 52.8 mg/kg in the scPTZ seizures test, resp. They also showed lower neurotoxicity and therefore a higher protective index. In particular, compound I (R = 4-fluorobenzyl; R1 = 1H-1,2,4-triazol-3-ylthio) showed high protective index (PI) values of 8.96 in the MES test and 9.30 in the scPTZ test, which were better than those of the standard drugs used as pos. controls in this study. This study involved multiple reactions and reactants, such as 6-Butoxybenzo[d]thiazol-2-amine (cas: 14372-65-7Quality Control of 6-Butoxybenzo[d]thiazol-2-amine).

6-Butoxybenzo[d]thiazol-2-amine (cas: 14372-65-7) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Quality Control of 6-Butoxybenzo[d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica