Day: November 25, 2022

Prier, Christopher K. published the artcileAmine α-heteroarylation via photoredox catalysis: a homolytic aromatic substitution pathway, Category: thiazole, the publication is Chemical Science (2014), 5(11), 4173-4178, database is CAplus and MEDLINE.

The direct α-heteroarylation of tertiary amines has been accomplished via photoredox catalysis to generate valuable benzylic amine pharmacophores. A variety of five- and six-membered chloroheteroarenes are shown to function as viable coupling partners for the α-arylation of a diverse range of cyclic and acyclic amines. Evidence is provided for a homolytic aromatic substitution mechanism, in which a catalytically-generated α-amino radical undergoes direct addition to an electrophilic chloroarene.

Chemical Science published new progress about 329794-40-3. 329794-40-3 belongs to thiazole, auxiliary class Thiazole,Chloride,Benzene, name is 2-Chloro-5-phenylthiazole, and the molecular formula is C9H6ClNS, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Chen, Yuncan published the artcileSynthesis of 2-aminothiazoles via rhodium-catalyzed carbenoid insertion/annulation of sulfoxonium ylides with thioureas, Name: 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Chinese Chemical Letters (2021), 32(8), 2555-2558, database is CAplus.

Sulfoxonium ylides as carbene precursors couple smoothly with thioureas in the presence of 5 mol% of rhodium(II) acetate dimmer via carbenoid insertion to afford the corresponding 2-aminothiazoles with high chemoselectivity, provided a facile and efficient approach to access a variety of 2-aminothiazole derivatives with good functional groups tolerance.

Chinese Chemical Letters published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Name: 4-(Naphthalen-1-yl)thiazol-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Wu, Dingsheng published the artcileBiomass-derived nanocellulose aerogel enable highly efficient immobilization of laccase for the degradation of organic pollutants, Safety of Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is Bioresource Technology (2022), 127311, database is CAplus and MEDLINE.

Laccase is a promising biocatalyst for pollutant degradation and water purification However, laccase can only improve the stability of enzyme activity and achieve its significant catalytic effect after effective immobilization. Herein, we report a general strategy to integrate nanocellulose aerogel and laccase for high-efficiency degradation of organic pollutants. Biomass-derived functional bacterial cellulose (BC) aerogel with a nanonetwork structure and high porosity was prepared by biosynthesis, solvent replacement, and atom transfer radical polymerization (ATRP) procedures. Subsequently, a biocatalyst platform was fabricated by “coupling” ATRP-modified BC aerogel with abundant active sites with laccase through ion coordination. The results demonstrated the biocatalyst platform not only has good biol. affinity, but also has high enzyme load and structural stability. Meanwhile, the degradation rates of reactive red X-3B and 2, 4-dichlorophenol reached 94.5% and 85.2% within 4 h, resp. The strategy disclosed herein could provide a practical method for the degradation of organic pollutants.

Bioresource Technology published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C8H14O2, Safety of Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Gong, Xiaobei published the artcileProduction of Red Pigments by a Newly Isolated Talaromyces aurantiacus Strain with LED Stimulation for Screen Printing, Name: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is Indian Journal of Microbiology (2022), 62(2), 280-292, database is CAplus and MEDLINE.

Microbial pigments have been widely applied to printing in food, textile, and paper industries as a sustainable alternative to synthetic dyes. Herein, we isolated a novel Talaromyces aurantiacus strain with a strong ability to produce red pigments. We further studied pigment production conditions, stability, screen printing application, and bioactivities. Our results showed that sucrose was a favorable carbon source and the addition of L-histidine significantly enhanced the production of red pigments. Pigment production was strictly photo-regulated with effective wavelengths around 450 nm (blue light). We mixed the red pigments with cellulosic materials and explored their application potentials for screen printing on paper, cotton fabrics, and polymeric carriers. The printing d. was significantly improved from 0.3 to 0.7 by overlay printing. T. aurantiacus pigments could be stably stored at pH 5-11, temperature – 10 to 70°C, and redox potential – 200 to 300 mV. Moreover, the stable ranges were extended to pH 1-11 and temperature over 100°C after screen-printed on paper. The red pigments exhibited antioxidant activity toward 2,2′-Azinobis-(3-ethylbenzthiazoline-6-sulfonate) (IC₅₀ 10.4 mg L^-1 in solution). Our results further indicated the red pigments by T. aurantiacus was environmentally friendly based on acetylcholinesterase activity assay.

Indian Journal of Microbiology published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Name: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Laghezza, Antonio published the artcileVirtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors, Category: thiazole, the publication is Bioorganic & Medicinal Chemistry (2020), 28(3), 115257, database is CAplus and MEDLINE.

Matrix metalloproteinases (MMPs) are a large family of zinc-dependent endoproteases known to exert multiple regulatory roles in tumor progression and invasiveness. This encouraged over the years the approach of MMP, and particularly MMP-2, targeting for anticancer treatment. Early generations of MMP inhibitors, based on aspecific zinc binding groups (ZBGs) assembled on (pseudo)peptide scaffolds, have been discontinued due to the clin. emergence of toxicity and further drawbacks, giving the way to inhibitors with alternative zinc-chelator moieties or not binding the catalytic zinc ion. In the present paper, we continue the search for new non-zinc binding MMP-2 inhibitors: exploiting previously identified compounds, a virtual screening (VS) campaign was carried out and led to the identification of a new class of ligands. The structure-activity relationship (SAR) of the benzimidazole scaffold was explored by synthesis of several analogs whose inhibition activity was tested with enzyme inhibition assays. By performing the mol. simplification approach, we disclosed different sets of single-digit micromolar inhibitors of MMP-2, with up to a ten-fold increase in inhibitory activity and ameliorated selectivity towards off-target MMP-8, compared to selected lead compound Mol. dynamics calculations conducted on complexes of MMP-2 with docked privileged structures confirmed that analyzed inhibitors avoid targeting the zinc ion and dip inside the S1′ pocket. Present results provide a further enrichment of our insights for the design of novel MMP-2 selective inhibitors.

Bioorganic & Medicinal Chemistry published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Tang, Yin published the artcileStudy on chemical components, antioxidant activity and cognitive improvement of borneol essential oil, Computed Properties of 30931-67-0, the publication is Riyong Huaxue Gongye (2021), 51(11), 1095-1101, database is CAplus.

Gas chromatog.-mass spectrometry (GC-MS) technol. was used to detect chem. compositions and their relative contents of borneol essential oil. By analyzing scavenging activity of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and 2,2′-azinobis[3-ethylbenzothiazoline-6-sulfonicacid]-diammonium salt (ABTS) free radical, the antioxidant activity of borneol essential oil and trolox were determined in vitro. In order to explore the effect of borneol essential oil on behavior of mice with learning and memory impairment, Morris water maze test and immunohistochem. experiment were used to judge the cognitive function of mice in normal group, model group, borneol essential oil group and pos. group. In addition, after completing the animal behavior experiment, the levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and malondialdehyde (MDA) of brain tissue were measured. The results showed that there were 43 main chem. components in borneol essential oil, such as borneol, D-limonene and 1,8-cineole. Free radical scavenging experiment finds that a certain concentration of borneol essential oil can effectively clean up DPPH and ABTS free radical, but its scavenging ability is less than trolox. The half maximal inhibitory concentration (IC₅₀) of borneol essential oil on DPPH and ABTS free radical were 1.65 and 2.27 g/L, resp. In Morris water maze, compared to mice in model group, the escape latency and crossing times of mice in borneol essential oil group were improved, and the performance of mice in borneol essential oil group was close to that in pos. group. In immunohistochem. experiment, the immunohistochem. section indicated that compared to mice in model group, the β-amyloid protein of mice in borneol essential oil group decreased, and the situation of mice in borneol essential oil group was close to that in pos. group. Compared to mice in model group, the activities of SOD and GSH-PX increased, and the content of MDA decreased in brain tissue of mice in borneol essential oil group. In conclusion, borneol essential oil has certain antioxidant activity in vitro and in vivo, and can improve cognitive impairment in mice.

Riyong Huaxue Gongye published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C6H6N2O, Computed Properties of 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Wang, Jing published the artcileLabel-free colorimetric detection of acid phosphatase and screening of its inhibitors based on biomimetic oxidase activity of MnO₂ nanosheets, Quality Control of 30931-67-0, the publication is ACS Biomaterials Science & Engineering (2020), 6(5), 3132-3138, database is CAplus and MEDLINE.

In this research, we attempted to develop a sensitive colorimetric sensing strategy for the detection of acid phosphatase (ACP) based on MnO₂ nanosheets and explored its applications in screening and evaluating inhibitors of ACP. The MnO₂ nanosheets exhibit intrinsic biomimetic oxidase activity, which can catalyze the oxidation of the colorless 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonate) diammonium salt (ABTS) into green oxidized ABTS (oxABTS). Upon the introduction of ACP, L-ascorbic acid-2-phosphate can be dephosphorylated to ascorbic acid, which arouses the disintegration of MnO₂ nanosheets into Mn²⁺ ions. This disintegration weakens the enzyme mimicking activity of the MnO₂ nanosheets, leading to the impediment of the oxidation of ABTS. Conversely, in the absence of ACP, the ABTS is rapidly oxidized by MnO₂, leading to a significant colorimetric signal change. The absorbance difference at 420 nm displayed a linear relationship with the concentration of ACP ranging from 0.075 to 0.45 mU·mL^-1, generating a detection limit of 0.046 mU·mL^-1. In the inhibition assays, this sensing platform provided simple detection for parathion-Me (PM), a representative inhibitor of ACP. The facile evaluation of the inhibitory effect of PM, including its IC₅₀ toward ACP, was also realized.

ACS Biomaterials Science & Engineering published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C5H6BNO2, Quality Control of 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Wang, Dan published the artcileDegradation of octylphenol polyethoxylates with a long ethoxylate chain using the laccase-mediated systems, Name: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is Environmental Science and Pollution Research (2021), 28(28), 37781-37792, database is CAplus and MEDLINE.

Alkylphenol polyethoxylates (APEO_n) are the second-largest category of com. nonionic surfactants, which are difficult to degrade naturally in the environment. This study examined the degradation of octylphenol polyethoxylate (OPEO_n) by laccase and its laccase-mediated systems. The results showed that OPEO_n was poorly degraded by laccase alone. 2, 2′-azino-bis [3-ethylbenzothiazoline-6-sulfonic acid] (ABTS), 1-hydroxybenzotriazole (HBT), and 2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPO) were selected as the redox mediators. Exptl. results also indicated that 52.4% of the initial OPEO_n amount was degraded by laccase in the presence of TEMPO. The degradation efficiency was analyzed using high-performance liquid chromatog. Furthermore, the structural characteristics of the degradation products were measured using matrix-assisted laser desorption/ionization-time of flight mass spectrometry and NMR spectroscopy, and it could be found that the laccase-TEMPO system could gradually shorten the ethoxylate chain by oxidizing the primary hydroxyl group of OPEO_n, thereby degrading the OPEO_n of the macromol. into small mols. The maximum of the ion peak distributions of OPEO_n decreased from n = 8 finally down to 3. The novel enzymic system introduced by this study will become a promising alternative method for high-efficiency APEO_n conversion and had great potential value in wastewater treatment.

Environmental Science and Pollution Research published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C7H11Br, Name: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Ke, Chaoqi published the artcileOrganocatalytic asymmetric synthesis of benzothiazolopyrimidines via a [4+2] cycloaddition of azlactones with 2-benzothiazolimines, Formula: C7H5ClN2S, the publication is Organic Chemistry Frontiers (2021), 8(20), 5705-5709, database is CAplus.

An easily available L-proline-derived guanidine-amide were found to be efficient at catalyzing a [4+2] cycloaddition of azlactones with 2-benzothiazolimines by affording various benzothiazolopyrimidines bearing adjacent tertiary and quaternary stereogenic centers in excellent yields at 2 mol% loading. The diastereoisomers of the main adducts differed from those in a previous bifunctional organocatalytic system.

Organic Chemistry Frontiers published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Formula: C7H5ClN2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Dong, Miao published the artcileSynergistic effect of copolymeric resin grafted 1,2-benzisothiazol-3(2H)-one and heterocyclic groups as a marine antifouling coating, COA of Formula: C7H5ClN2S, the publication is RSC Advances (2021), 11(31), 18787-18796, database is CAplus and MEDLINE.

In order to find a new type of antifouling coating with higher biol. activity and more environmental protection, heterocyclic compounds and benzoisothiazolinone were introduced into acrylic resin to prepare a new type of antifouling resin. In this study, a series of grafted acrylic resins simultaneously containing benzoisothiazolinone and heterocyclic monomers were prepared by the copolymerization of an allyl monomer with Me methacrylate (MMA) and Bu acrylate (BA). Inhibitory activities of the copolymers against marine fouling organisms were also investigated. Results revealed that the copolymers exhibit a clear synergistic inhibitory effect on the growth of three seaweeds: Chlorella, Isochrysis galbana and Chaetoceros curvisetus, resp., and three bacteria, Staphylococcus aureus, Vibrio coralliilyticus and Vibrio parahaemolyticus, resp. In addition, the copolymers exhibited excellent inhibition against barnacle larvae. Marine field tests indicated that the resins exhibit outstanding antifouling potency against marine fouling organisms. Moreover, the introduction of the heterocyclic group led to the significantly enhanced antifouling activities of the resins; the addition of the heterocyclic unit in copolymers led to better inhibition than that observed in the case of the resin copolymerized with only the benzoisothiazolinone active monomer.

RSC Advances published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, COA of Formula: C7H5ClN2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica