Day: November 25, 2022

Li, Peng published the artcileA label-free and signal-amplifiable assay method for colorimetric detection of carcinoembryonic antigen, Related Products of thiazole, the publication is Biotechnology and Bioengineering (2022), 119(2), 504-512, database is CAplus and MEDLINE.

In this work, an innovative colorimetric assay method for the determination of carcinoembryonic antigen is developed with aptamer probes utilized as recognition element. DNA hybridization chain reaction is used as signal amplification technique, and peroxidase-mimicking hemin/G-quadruplex-assisted catalytic oxidation of 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) is deployed as signal reporting mechanism. The detection principle was firstly verified by using gel electrophoresis anal. and absorbance measurements. After condition optimization, a detection limit was theor. determined as 24.8 ng/mL. Furthermore, the method exhibited good selectivity and satisfactory recovery rates (92.2%-108.6%) in serum samples. Moreover, the sensing scheme is easily extended for the detection of other analytes via similar target-aptamer recognition principle. To sum up, this is an enzyme- and label-free, cost-effective yet signal-amplifiable assay scheme for the determination of tumor markers with promising simplicity and selectivity, practical utility, and potential universality.

Biotechnology and Bioengineering published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Sun, Xin published the artcileNovel fluorescent cationic benzothiazole dye that responds to G-quadruplex aptamer as a novel K⁺ sensor, Application of 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Analyst (Cambridge, United Kingdom) (2017), 142(18), 3352-3355, database is CAplus and MEDLINE.

A fluorescent cationic benzothiazole dye (I) that selectively targets a G-quadruplex aptamer was designed and synthesized as a K⁺ sensor. The K⁺-driven aptamer sensor is based on the strategy of conformational transition from single-stranded DNA to G-quadruplex structure, leading to an amplified fluorescence signal in the reporter. This fluorescent sensor displayed high selectivity for K⁺, suggesting great potential for practical applications.

Analyst (Cambridge, United Kingdom) published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C6H9N3O2S, Application of 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Yang, Zaibo published the artcileNovel pyrethrin derivatives containing an 1,3,4-oxadiazole thioether moiety: Design, synthesis, and insecticidal activity, Application of 5-Chloro-2-(chloromethyl)-1,3-thiazole, the publication is Journal of Heterocyclic Chemistry (2020), 57(1), 81-88, database is CAplus.

In this study, a series of novel pyrethrin derivatives containing an 1,3,4-oxadiazole thioether moiety, I (R = Ph, 2-ClC₆H₄, 6-chloropyridinyl, etc.), were designed and synthesized. Bioassay results revealed that some of the target compounds possessed excellent insecticidal activities against Plutella xylostella (P. xylostella), Vegetable aphids (V. aphids), and Empoasca vitis (E. vitis), resp. In particular, compound I (R = 4-F₃CC₆H₄) revealed the best insecticidal activities against P. xylostella and V. aphids, with the 50% lethal concentration (LC₅₀) values of 1.78 and 1.61 mg/L, resp.; meanwhile, compound I (R = 5-chlorothiadiazol-2-yl) revealed the best insecticidal activity against E. vitis, with the LC₅₀ value of 1.06 mg/L, which were superior to those of the com. insecticidal agents of chlorpyrifos, beta cypermethrin, spinosad, and azadirachtin. These results indicated that novel pyrethrin derivatives containing an 1,3,4-oxadiazole thioether moiety could effectively inhibit P. xylostella, V. aphids, and E. vitis.

Journal of Heterocyclic Chemistry published new progress about 50398-77-1. 50398-77-1 belongs to thiazole, auxiliary class Thiazoles, name is 5-Chloro-2-(chloromethyl)-1,3-thiazole, and the molecular formula is C12H15BClFO2, Application of 5-Chloro-2-(chloromethyl)-1,3-thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Zaldivar-Diez, Josefa published the artcileBenzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate, Related Products of thiazole, the publication is Journal of Medicinal Chemistry (2020), 63(5), 2638-2655, database is CAplus and MEDLINE.

Leucine rich repeat kinase 2 (LRRK2) is an enigmatic enzyme and a relevant target for Parkinson’s disease (PD). However, despite the significant amount of research done in the past decade, the precise function of LRRK2 remains largely unknown. Moreover, the therapeutic potential of its inhibitors is in its infancy with the first clin. trial having just started. In the present work, the mol. mechanism of LRRK2 in the control of neurogenesis or gliogenesis was investigated. We designed and synthesized novel benzothiazole-based LRRK2 inhibitors and showed that they can modulate the Wnt/β-catenin signaling pathway. Furthermore, compounds I and II were able to promote neural progenitors proliferation and drive their differentiation toward neuronal and oligodendrocytic cell fates. These results suggest potential new avenues for the application of LRRK2 inhibitors in demyelinating diseases in which oligodendrocyte cell-death is one of the pathol. features.

Journal of Medicinal Chemistry published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C10H16O2, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Chen, Zhicai published the artcileImide-Functionalized Fluorenone and Its Cyanated Derivative Based n-Type Polymers: Synthesis, Structure-Property Correlations, and Thin-Film Transistor Performance, Safety of 4,4′-Bis(octyloxy)-2,2′-bis(trimethylstannyl)-5,5′-bithiazole, the publication is Angewandte Chemie, International Edition (2022), 61(32), e202205315, database is CAplus and MEDLINE.

The development of high-performance n-type polymer semiconductors is powered by the design and synthesis of electron-deficient building blocks with optimized physicochem. properties. By meticulously installing an imide group onto fluorene and its cyanated derivative, we report here two very electron-deficient building blocks, imide-functionalized fluorenone (FOI) and its cyanated derivative (FCNI), both featuring a deep-lying LUMO energy level down to -4.05 eV and highly coplanar framework, endowing them ideal units for constructing n-type polymers. Thus, a series of polymers are built from them, exhibiting unipolar n-type transport character with a highest electron mobility of 0.11 cm² V^-1 s^-1. Hence, FOI and FCNI offer a remarkable platform for accessing high-performance n-type polymers and the imide functionalization of appropriate (hetero)arenes is a powerful strategy for developing polymers with deep-lying LUMOs for n-type organic electronics.

Angewandte Chemie, International Edition published new progress about 2215018-37-2. 2215018-37-2 belongs to thiazole, auxiliary class Thiazoles, name is 4,4′-Bis(octyloxy)-2,2′-bis(trimethylstannyl)-5,5′-bithiazole, and the molecular formula is C28H52N2O2S2Sn2, Safety of 4,4′-Bis(octyloxy)-2,2′-bis(trimethylstannyl)-5,5′-bithiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Jiang, Zhengxing published the artcileBlue Light-Gated Reversible Silver Nanozyme Reaction Networks that Achieve Life-like Adaptivity, Product Details of C18H24N6O6S4, the publication is ACS Sustainable Chemistry & Engineering (2020), 8(13), 5076-5081, database is CAplus.

Life is preserved by complex enzymic reaction systems. Inspired by life, here the authors report on the first example to fabricate blue light-gated reversible silver nanozyme reaction networks that achieve life-like adaptivity. Upon blue light excitation, silver nanoparticles (AgNPs) display oxidase-like activity in the presence of Cl^– as a cofactor. The addition of Cl^– promotes the separation between hot holes and electrons that are generated by excited-state surface plasmon of AgNPs, inducing the generation of highly reactive hydroxyl and superoxide anion radicals. They oxidize colorless 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)diammonium salt (ABTS) to yield green ABTS radicals (ABTS^•+). It is shown that ABTS^•+ is able to be reduced by AgNPs to regenerate ABTS when the blue light is turned off, and the reaction system returns to its initial state, which is the typical feature of the artificial adaptive system. The dynamic process of the adaptive system is tunable by changing the concentrations of AgNPs and Cl^–, and it possesses excellent recyclable performance, which can be repeated at least six times. Overall, the silver nanozyme reaction networks are capable of responding to blue light stimuli and renewing by recycling to the initial state without blue light irradiation Inspired by enzymic reaction systems, blue light-gated reversible silver nanozyme reaction networks that achieve life-like adaptivity are successfully constructed.

ACS Sustainable Chemistry & Engineering published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Product Details of C18H24N6O6S4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Hu, Min-Qi published the artcile1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors, Application In Synthesis of 92-36-4, the publication is RSC Advances (2020), 10(71), 43299-43311, database is CAplus and MEDLINE.

Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.

RSC Advances published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Application In Synthesis of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

He, Zhi-Tao published the artcileTrimethylphosphate as a Methylating Agent for Cross Coupling: A Slow-Release Mechanism for the Methylation of Arylboronic Esters, Application In Synthesis of 791614-90-9, the publication is Journal of the American Chemical Society (2018), 140(49), 17197-17202, database is CAplus and MEDLINE.

Tri-Me phosphate acted as an effective source of Me groups; in the presence of CuI, and LiI, (MeO)₃P(:O) underwent chemoselective coupling with arylpinacolboronates mediated by LiOt-Bu in 1,3-dimethylimidazolidin-2-one (DMI) to yield methylarenes in higher yields than related coupling reactions using either Me iodide or Me tosylate. The methylation reaction was used in tandem with iridium-catalyzed regioselective borylation with bis(pinacolato)diboron to provide a one-pot methylation reaction for arenes, and for trideuteromethylation of arylpinacoboronates using tris(trideuteromethyl) phosphate. The chemoselectivity of the reaction was tested using additives possessing various functional groups (robustness screen); unprotected amines, alcs., and amides and terminal alkynes were not tolerated. The methylation of 1-naphthylpinacolboronate was demonstrated on a 200 mmol scale. The kinetics of the methylation and its dependence on Li⁺ and I^– ions was determined and a mechanism suggested. Me iodide is released slowly upon reaction of tri-Me phosphate with iodide; the low concentration of MeI enables selective reaction with arylcopper intermediates generated from the arylboronate rather than with other nucleophiles, while binding of tert-butoxide to the pinacolboronate reactants inhibits reaction of MeI with tert-butoxide.

Journal of the American Chemical Society published new progress about 791614-90-9. 791614-90-9 belongs to thiazole, auxiliary class Boronate Esters,Boronic acid and ester,Boronic acid and ester, name is 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole, and the molecular formula is C14H18BNO2S, Application In Synthesis of 791614-90-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Quan, Zheshan published the artcileSynthesis of 4-amino-5-chloro-2,1,3-benzothiadiazole, Safety of 5-Chlorobenzo[c][1,2,5]thiadiazol-4-amine, the publication is Huaxue Shiji (2003), 25(2), 115, 117, database is CAplus.

4-Amino-5-chloro-2,1,3-benzothiadiazole was synthesized in 61.2% overall yield from 4-chloro-2-nitro-aniline as raw material by reduction, cyclization, nitration and reduction The structure of the product obtained was confirmed by MS and ¹HNMR.

Huaxue Shiji published new progress about 30536-19-7. 30536-19-7 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Chloride,Amine, name is 5-Chlorobenzo[c][1,2,5]thiadiazol-4-amine, and the molecular formula is C6H4ClN3S, Safety of 5-Chlorobenzo[c][1,2,5]thiadiazol-4-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Keil, Oliver published the artcileHyphenation of capillary high-performance liquid chromatography with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for nano-scale screening of single-bead combinatorial libraries, Computed Properties of 92-36-4, the publication is Rapid Communications in Mass Spectrometry (2002), 16(8), 814-820, database is CAplus and MEDLINE.

This paper focuses on the tech. aspects of chem. screening from 384-well plate nano-scale single-bead combinatorial libraries. The anal. technique utilized is a combination of capillary liquid chromatog. with UV detection and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. The HPLC/MALDI-MS hyphenation is achieved by means of a micro-fraction collector with a peak detection system that automatically collects the peaks onto the MALDI targets for subsequent characterization. Several exptl. parameters such as type of 384-well plate, well-plate sealing foils, and a column-switching procedure were investigated using a small test library of nine components. Addnl., the influence of different MALDI matrixes, different MALDI targets and sample-spotting techniques on the MALDI detection sensitivity as well as the ruggedness and sample throughput capacity of this technique were studied. Optimum results for the analytes investigated were obtained with 2,5-dihydroxybenzoic acid using online mixing of HPLC effluent and matrix solution To demonstrate the potential of this capillary HPLC/MALDI-TOFMS method, its application to several single-bead libraries was investigated. The instrumental method allowed for the rapid identification and purity assessment of combinatorial libraries with detection limits down to the higher femtomole level using both UV detection and MALDI mass spectrometry.

Rapid Communications in Mass Spectrometry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Computed Properties of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica