Tang, Yin published the artcileStudy on chemical components, antioxidant activity and cognitive improvement of borneol essential oil, Computed Properties of 30931-67-0, the publication is Riyong Huaxue Gongye (2021), 51(11), 1095-1101, database is CAplus.
Gas chromatog.-mass spectrometry (GC-MS) technol. was used to detect chem. compositions and their relative contents of borneol essential oil. By analyzing scavenging activity of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and 2,2′-azinobis[3-ethylbenzothiazoline-6-sulfonicacid]-diammonium salt (ABTS) free radical, the antioxidant activity of borneol essential oil and trolox were determined in vitro. In order to explore the effect of borneol essential oil on behavior of mice with learning and memory impairment, Morris water maze test and immunohistochem. experiment were used to judge the cognitive function of mice in normal group, model group, borneol essential oil group and pos. group. In addition, after completing the animal behavior experiment, the levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and malondialdehyde (MDA) of brain tissue were measured. The results showed that there were 43 main chem. components in borneol essential oil, such as borneol, D-limonene and 1,8-cineole. Free radical scavenging experiment finds that a certain concentration of borneol essential oil can effectively clean up DPPH and ABTS free radical, but its scavenging ability is less than trolox. The half maximal inhibitory concentration (IC50) of borneol essential oil on DPPH and ABTS free radical were 1.65 and 2.27 g/L, resp. In Morris water maze, compared to mice in model group, the escape latency and crossing times of mice in borneol essential oil group were improved, and the performance of mice in borneol essential oil group was close to that in pos. group. In immunohistochem. experiment, the immunohistochem. section indicated that compared to mice in model group, the β-amyloid protein of mice in borneol essential oil group decreased, and the situation of mice in borneol essential oil group was close to that in pos. group. Compared to mice in model group, the activities of SOD and GSH-PX increased, and the content of MDA decreased in brain tissue of mice in borneol essential oil group. In conclusion, borneol essential oil has certain antioxidant activity in vitro and in vivo, and can improve cognitive impairment in mice.
Riyong Huaxue Gongye published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C6H6N2O, Computed Properties of 30931-67-0.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica