Yang, Zaibo published the artcileNovel pyrethrin derivatives containing an 1,3,4-oxadiazole thioether moiety: Design, synthesis, and insecticidal activity, Application of 5-Chloro-2-(chloromethyl)-1,3-thiazole, the publication is Journal of Heterocyclic Chemistry (2020), 57(1), 81-88, database is CAplus.
In this study, a series of novel pyrethrin derivatives containing an 1,3,4-oxadiazole thioether moiety, I (R = Ph, 2-ClC6H4, 6-chloropyridinyl, etc.), were designed and synthesized. Bioassay results revealed that some of the target compounds possessed excellent insecticidal activities against Plutella xylostella (P. xylostella), Vegetable aphids (V. aphids), and Empoasca vitis (E. vitis), resp. In particular, compound I (R = 4-F3CC6H4) revealed the best insecticidal activities against P. xylostella and V. aphids, with the 50% lethal concentration (LC50) values of 1.78 and 1.61 mg/L, resp.; meanwhile, compound I (R = 5-chlorothiadiazol-2-yl) revealed the best insecticidal activity against E. vitis, with the LC50 value of 1.06 mg/L, which were superior to those of the com. insecticidal agents of chlorpyrifos, beta cypermethrin, spinosad, and azadirachtin. These results indicated that novel pyrethrin derivatives containing an 1,3,4-oxadiazole thioether moiety could effectively inhibit P. xylostella, V. aphids, and E. vitis.
Journal of Heterocyclic Chemistry published new progress about 50398-77-1. 50398-77-1 belongs to thiazole, auxiliary class Thiazoles, name is 5-Chloro-2-(chloromethyl)-1,3-thiazole, and the molecular formula is C12H15BClFO2, Application of 5-Chloro-2-(chloromethyl)-1,3-thiazole.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica