Day: November 28, 2022

Studies towards the total synthesis of epothilones: asymmetric synthesis of the key fragments was written by Schinzer, Dieter;Limberg, Anja;Boehm, Oliver M.. And the article was included in Chemistry – A European Journal in 1996.Product Details of 74704-39-5 The following contents are mentioned in the article:

Three key intermediates, the C(1)-C(6) and C(7)-C(12) fragments and a side chain fragment of epothilones A and B were prepared This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Product Details of 74704-39-5).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Product Details of 74704-39-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Investigation of novel 7,8-disubstituted-5,10-dihydrodibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors was written by Hasvold, Lisa A.;Wang, Le;Przytulinska, Magdalena;Xiao, Zhan;Chen, Zehan;Gu, Wen-Zhen;Merta, Philip J.;Xue, John;Kovar, Peter;Zhang, Haiying;Park, Chang;Sowin, Thomas J.;Rosenberg, Saul H.;Lin, Nan-Horng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Reference of 74704-39-5 The following contents are mentioned in the article:

The synthesis and structure-activity relationships (SAR) of Chk1 inhibitors based on a 5,10-dihydrodibenzo[b,e][1,4]diazepin-11-one core are described. Specifically, an exploration of the 7 and 8 positions on this core afforded compounds with improved enzymic and cellular potency. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Reference of 74704-39-5).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Reference of 74704-39-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Synthesis of some 4H-pyrimido[2,1-b]benzothiazol-4-ones was written by Alaimo, Robert J.. And the article was included in Journal of Heterocyclic Chemistry in 1973.Application of 14372-65-7 The following contents are mentioned in the article:

A series of 8-substituted and 7,8-disubstituted-4-oxo-3-(4H-pyrimido[2,1-b]benzothiazole)carboxylic acids (I) and esters including a 9-aza analog were synthesized from substituted 2-aminobenzothiazoles and di-Et ethoxymethylenemalonate. No significant antiparasitic activity was detected. This study involved multiple reactions and reactants, such as 6-Butoxybenzo[d]thiazol-2-amine (cas: 14372-65-7Application of 14372-65-7).

6-Butoxybenzo[d]thiazol-2-amine (cas: 14372-65-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Application of 14372-65-7

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Synthesis of some 4H-pyrimido[2,1-b]benzothiazol-4-ones was written by Alaimo, Robert J.. And the article was included in Journal of Heterocyclic Chemistry in 1973.Category: thiazole The following contents are mentioned in the article:

A series of 8-substituted and 7,8-disubstituted-4-oxo-3-(4H-pyrimido[2,1-b]benzothiazole)carboxylic acids (I) and esters including a 9-aza analog were synthesized from substituted 2-aminobenzothiazoles and di-Et ethoxymethylenemalonate. No significant antiparasitic activity was detected. This study involved multiple reactions and reactants, such as 6-Isopropoxybenzo[d]thiazol-2-amine (cas: 15850-81-4Category: thiazole).

6-Isopropoxybenzo[d]thiazol-2-amine (cas: 15850-81-4) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Benzimidazole-4,7-diones as Inhibitors of Protozoal (Toxoplasma gondii) Purine Nucleoside Phosphorylase was written by Alvarez, Frederic;Gherardi, Arnaud;Nebois, Pascal;Sarciron, Marie-Elizabeth;Petavy, Anne-Francoise;Walchshofer, Nadia. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.Formula: C5H6BrNS The following contents are mentioned in the article:

Benzimidazole-4,7-diones substituted at the 1- and/or 2-position, e.g., I (R¹ = H, Me), have been synthesized and tested as inhibitors of purine nucleoside phosphorylase isolated from two strains of Toxoplasma gondii (RH and ME 49). They were identified as inhibitors of both enzymes. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Formula: C5H6BrNS).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Formula: C5H6BrNS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

A small-molecule antagonist of the Hedgehog signaling pathway was written by Lee, Jongkook;Wu, Xu;Pasca di Magliano, Marina;Peters, Eric C.;Wang, Yan;Hong, Jiyong;Hebrok, Metthias;Ding, Sheng;Cho, Charles Y.;Schultz, Peter G.. And the article was included in ChemBioChem in 2007.SDS of cas: 315703-52-7 The following contents are mentioned in the article:

Shadow the Hedgehog. JK184 (illustrated in the scheme) was identified as an antagonist of Hedgehog signaling through a cell-based screen of chem. libraries. Results from biochem. and cellular experiments suggest that JK184 functions by inhibiting ge. This mol. should serve as a useful tool for studying Hedgehog signaling. This study involved multiple reactions and reactants, such as N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7SDS of cas: 315703-52-7).

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.SDS of cas: 315703-52-7

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

SAR studies on thiazolo[4,5-d]pyrimidine based CXCR2 antagonists involving a novel tandem displacement reaction was written by Hunt, Fraser;Austin, Caroline;Austin, Rupert;Bonnert, Roger;Cage, Peter;Christie, Jadeen;Christie, Mark;Dixon, Clare;Hill, Steven;Jewell, Robert;Martin, Ian;Robinson, David;Willis, Paul. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Recommanded Product: 74704-39-5 The following contents are mentioned in the article:

As part of a Lead Optimization program to identify small mol. antagonists of the human CXCR2 receptor, a series of substituted thiazolo[4,5-d]pyrimidines was prepared via the application of a novel tandem displacement reaction. E.g., thiazolo[4,5-d]pyrimidine I was prepared from II via a tandem amination. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Recommanded Product: 74704-39-5).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 74704-39-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Novel, selective indole-based ECE inhibitors: Lead optimization via solid-phase and classical synthesis was written by Brands, Michael;Ergueden, Jens-Kerim;Hashimoto, Kentaro;Heimbach, Dirk;Schroeder, Christian;Siegel, Stephan;Stasch, Johannes-Peter;Weigand, Stefan. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Electric Literature of C5H6BrNS The following contents are mentioned in the article:

A novel class of indole-based endothelin-converting enzyme (ECE) inhibitors was identified by high throughput screening. Systematic optimization of this compound class by means of classical and solid-phase chem. is reported. Optimized compounds with a bisarylamide side chain at the 2-position of the indole skeleton exhibit low-nanomolar activity on ECE. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Electric Literature of C5H6BrNS).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Electric Literature of C5H6BrNS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The imidazopyridine derivative JK184 reveals dual roles for microtubules in hedgehog signaling was written by Cupido, Tommaso;Rack, Paul G.;Firestone, Ari J.;Hyman, Joel M.;Han, Kyuho;Sinha, Surajit;Ocasio, Cory A.;Chen, James K.. And the article was included in Angewandte Chemie, International Edition in 2009.Recommanded Product: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine The following contents are mentioned in the article:

Eradicating hedgehogs: The title mol. has been previously identified as a potent inhibitor of the Hedgehog signaling pathway, which gives embryonic cells information needed to develop properly. This mol. is shown to modulate Hedgehog target gene expression by depolymerizing microtubules, thus revealing dual roles of the cytoskeleton in pathway regulation. This study involved multiple reactions and reactants, such as N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7Recommanded Product: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine).

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Recommanded Product: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Pantolactams as androgen receptor antagonists for the topical suppression of sebum production was written by Sexton, Karen E.;Barrett, Stephen;Bridgwood, Katy;Carroll, Matthew;Dettling, Danielle;Du, Daniel;Fakhoury, Stephen;Fedij, Victor;Hu, Lain-Yen;Kostlan, Catherine;Pocalyko, David;Raheja, Neil;Smith, Yvonne;Shanmugasundaram, Veerabahu;Wade, Kimberly. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Category: thiazole The following contents are mentioned in the article:

A series of pantolactam based compounds were identified as potent antagonists for the androgen receptor (AR). Those that possessed properties suitable for topical delivery were evaluated in the validated Hamster Ear Model. Several compounds were found to be efficacious in reducing wax esters, a major component of sebum, initiating further preclin. work on these compounds This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Category: thiazole).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica