Alvarez, Frederic et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2002 | CAS: 74704-39-5

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Formula: C5H6BrNS

Benzimidazole-4,7-diones as Inhibitors of Protozoal (Toxoplasma gondii) Purine Nucleoside Phosphorylase was written by Alvarez, Frederic;Gherardi, Arnaud;Nebois, Pascal;Sarciron, Marie-Elizabeth;Petavy, Anne-Francoise;Walchshofer, Nadia. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.Formula: C5H6BrNS The following contents are mentioned in the article:

Benzimidazole-4,7-diones substituted at the 1- and/or 2-position, e.g., I (R1 = H, Me), have been synthesized and tested as inhibitors of purine nucleoside phosphorylase isolated from two strains of Toxoplasma gondii (RH and ME 49). They were identified as inhibitors of both enzymes. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Formula: C5H6BrNS).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Formula: C5H6BrNS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica