Crosignani, Stefano et al. published their research in Journal of Medicinal Chemistry in 2008 | CAS: 74704-39-5

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Computed Properties of C5H6BrNS

Discovery of a New Class of Potent, Selective, and Orally Bioavailable CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases was written by Crosignani, Stefano;Page, Patrick;Missotten, Marc;Colovray, Veronique;Cleva, Christophe;Arrighi, Jean-Francois;Atherall, John;Macritchie, Jackie;Martin, Thierry;Humbert, Yves;Gaudet, Marilene;Pupowicz, Doris;Maio, Maurizio;Pittet, Pierre-Andre;Golzio, Lucia;Giachetti, Claudio;Rocha, Cynthia;Bernardinelli, Gerald;Filinchuk, Yaroslav;Scheer, Alexander;Schwarz, Matthias K.;Chollet, Andre. And the article was included in Journal of Medicinal Chemistry in 2008.Computed Properties of C5H6BrNS The following contents are mentioned in the article:

A novel chem. class of potent chemoattractant receptor-homologous expressed on Th2 lymphocytes (CRTH2 or DP2) antagonists is reported. An initial and moderately potent spiro-indolinone compound (I) was found during a high-throughput screening campaign. Structure-activity relationship (SAR) investigation around the carboxylic acid group revealed that changes in this part of the mol. could lead to a reversal of functional activity, yielding weakly potent agonists. SAR investigation of the succinimide functional group led to the discovery of several single-digit nanomolar antagonists. The potency of these compounds was confirmed in a human eosinophil chemotaxis assay. Moreover, compounds II and III were shown to possess pharmacokinetic properties suitable for development as an orally bioavailable drug. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Computed Properties of C5H6BrNS).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Computed Properties of C5H6BrNS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica