Francisco, Gerardo D. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2004 | CAS: 303994-99-2

2-Amino-4-(tert-butyl)thiazole-5-carbonitrile (cas: 303994-99-2) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Product Details of 303994-99-2

Phenyl thiazolyl urea and carbamate derivatives as new inhibitors of bacterial cell-wall biosynthesis was written by Francisco, Gerardo D.;Li, Zhong;Albright, J. Donald;Eudy, Nancy H.;Katz, Alan H.;Petersen, Peter J.;Labthavikul, Pornpen;Singh, Guy;Yang, Youjun;Rasmussen, Beth A.;Lin, Yang-I.;Mansour, Tarek S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Product Details of 303994-99-2 The following contents are mentioned in the article:

Over 50 Ph thiazolyl urea and carbamate derivatives were synthesized for evaluation as new inhibitors of bacterial cell-wall biosynthesis. Many of them demonstrated good activity against MurA and MurB and gram-pos. bacteria including MRSA, VRE and PRSP. (3,4-Difluorophenyl)(5-cyanothiazolyl)urea with clog P of 2.64 demonstrated antibacterial activity against both gram-pos. and gram-neg. bacteria. The activity of these (phenyl)(thiazolyl)urea and (thiazolyl)carbamate derivatives was also compared to 3-[[[(3,4-dichlorophenyl)amino]carbonyl]amino]-2-thiophenecarboxylic acid Me ester, 5-[[[(3,4-dichlorophenyl)amino]carbonyl]amino]-1-methyl-1H-pyrazole-4-carboxylic acid Me ester, N-(3,4-dichlorophenyl)-N‘-(2-pyridinyl)urea, and some other compounds Antibacterial activity was screened against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococus (VRE), penicillin-resistant Streptococcus pneumoniae (PRSP). Mol. modeling studies were carried out to explore binding preferences within this compound series in the MurB structure. This study involved multiple reactions and reactants, such as 2-Amino-4-(tert-butyl)thiazole-5-carbonitrile (cas: 303994-99-2Product Details of 303994-99-2).

2-Amino-4-(tert-butyl)thiazole-5-carbonitrile (cas: 303994-99-2) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Product Details of 303994-99-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica