Relation between physiological action and chemical structure. II. Pharmacological studies on various benzothiazole derivatives was written by Fujimura, Hajime. And the article was included in Bulletin of the Institute for Chemical Research, Kyoto University in 1950.Application of 15850-81-4 The following contents are mentioned in the article:
cf. Folia Pharmacol. Japon. 44, 6(1949). The potentiating effects of 2-amino-(I), 2-amino-6-methoxy-(II), 2-amino-6-ethoxy-(III), 2-amino-6-isopropoxy-(IV), 2-(2-diethylaminoethylamino)-6-methoxy-(V), and 2-(2-diethylaminoethylamino)-6-ethoxybenzothiazole (VI) on the hypnotic action of evipan and the analgesic action of morphine were studied. I-VI prolonged the duration of evipan action (30 min. by 50 mg./kg.) in mice 50, 150, 200, 500, 17, and 17%, resp., by injection of 20 mg./kg., 15 min. before the administration of evipan. As determined by Haffner’s method in mice, they did not increase the morphine action (5 mg./kg.). When administered with benadryl (10 mg./kg.), II, III, and IV increased it while I, V, and VI did not. The presence of an alkoxy radical in the 6-position of the benzothiazole ring appears to play an important role in increasing the actions of these 2 drugs, while further substitution of H of the amino radical in the 2-position by the diethylaminoethyl group may result in their inhibition. This study involved multiple reactions and reactants, such as 6-Isopropoxybenzo[d]thiazol-2-amine (cas: 15850-81-4Application of 15850-81-4).
6-Isopropoxybenzo[d]thiazol-2-amine (cas: 15850-81-4) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Application of 15850-81-4
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica