Investigation of novel 7,8-disubstituted-5,10-dihydrodibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors was written by Hasvold, Lisa A.;Wang, Le;Przytulinska, Magdalena;Xiao, Zhan;Chen, Zehan;Gu, Wen-Zhen;Merta, Philip J.;Xue, John;Kovar, Peter;Zhang, Haiying;Park, Chang;Sowin, Thomas J.;Rosenberg, Saul H.;Lin, Nan-Horng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Reference of 74704-39-5 The following contents are mentioned in the article:
The synthesis and structure-activity relationships (SAR) of Chk1 inhibitors based on a 5,10-dihydrodibenzo[b,e][1,4]diazepin-11-one core are described. Specifically, an exploration of the 7 and 8 positions on this core afforded compounds with improved enzymic and cellular potency. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Reference of 74704-39-5).
4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Reference of 74704-39-5
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica