He, Xiuting et al. published their research in Journal of Drug Delivery Science and Technology in 2021 | CAS: 38215-36-0

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Reference of 38215-36-0

Preparation and evaluation of SN-38-loaded MMP-2-responsive polymer micelles was written by He, Xiuting;Cao, Zhongcheng;Li, Nuannuan;Chu, Liuxiang;Wang, Jiazhen;Zhang, Chunyan;He, Xiaoyan;Lu, Xiaoyan;Sun, Kaoxiang;Meng, Qingguo. And the article was included in Journal of Drug Delivery Science and Technology in 2021.Reference of 38215-36-0 The following contents are mentioned in the article:

7-Ethyl-10-hydroxycamptothecin (SN-38)-loaded polyethylene glycol-GPLGVRG-poly β-benzyl-L-aspartic acid (PEG-GPLGVRG-PBLA) self-assemblies were successfully prepared using a classical nanopptn. method to give an enzyme-responsive nano-drug delivery system. The PEG-GPLGVRG-PBLA/SN-38 self-assemblies were characterized by transmission electron microscopy, dynamic light scattering, and high-performance liquid chromatog. The encapsulation efficiency was 91.7 ± 1.21% and the drug loading was 16.6 ± 0.93%. The 12 h in vitro release of SN-38 from PEG-GPLGVRG-PBLA/SN-38 treated with MMP-2 was 73.2 ± 2.05%, which was significantly higher than that for the group without MMP-2, demonstrating the enzyme-responsiveness of the nano-drug delivery system. In addition, the cellular uptake and tumor accumulation of PEG-GPLGVRG-PBLA were better than those of PEG-PBLA, and the blank PEG-GPLGVRG-PBLA showed high biocompatibility. These findings indicate that the enzyme-responsive nano SN-38 delivery system could provide new opportunities in tumor therapy. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Reference of 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Reference of 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica