SAR studies on thiazolo[4,5-d]pyrimidine based CXCR2 antagonists involving a novel tandem displacement reaction was written by Hunt, Fraser;Austin, Caroline;Austin, Rupert;Bonnert, Roger;Cage, Peter;Christie, Jadeen;Christie, Mark;Dixon, Clare;Hill, Steven;Jewell, Robert;Martin, Ian;Robinson, David;Willis, Paul. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Recommanded Product: 74704-39-5 The following contents are mentioned in the article:
As part of a Lead Optimization program to identify small mol. antagonists of the human CXCR2 receptor, a series of substituted thiazolo[4,5-d]pyrimidines was prepared via the application of a novel tandem displacement reaction. E.g., thiazolo[4,5-d]pyrimidine I was prepared from II via a tandem amination. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Recommanded Product: 74704-39-5).
4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 74704-39-5
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica