Cyclopropanation of 3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-diones was written by Lack, Oliver;Martin, Rainer E.. And the article was included in Tetrahedron Letters in 2005.Related Products of 74704-39-5 The following contents are mentioned in the article:
A two step parallel synthesis protocol for the preparation of 1N-substituted spirobenzodiazepineones is described. Treatment of 4-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione with a series of alkyl halides using a microwave-assisted heating protocol provided N-derivatized compounds, which were transformed to the corresponding cyclopropylamines employing modified Kulinkovich-type reaction conditions. X-ray structural anal. gave conclusive evidence of the newly created spiro center and revealed a significant flattening of the seven-membered ring system compared with the benzodiazepinedione system providing a characteristically different pattern of bond exit vectors. The physicochem. parameters log D, pKa, solubility, and membrane permeability of both cyclopropanated and precursor compounds were assessed. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Related Products of 74704-39-5).
4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Related Products of 74704-39-5
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica