A small-molecule antagonist of the Hedgehog signaling pathway was written by Lee, Jongkook;Wu, Xu;Pasca di Magliano, Marina;Peters, Eric C.;Wang, Yan;Hong, Jiyong;Hebrok, Metthias;Ding, Sheng;Cho, Charles Y.;Schultz, Peter G.. And the article was included in ChemBioChem in 2007.SDS of cas: 315703-52-7 The following contents are mentioned in the article:
Shadow the Hedgehog. JK184 (illustrated in the scheme) was identified as an antagonist of Hedgehog signaling through a cell-based screen of chem. libraries. Results from biochem. and cellular experiments suggest that JK184 functions by inhibiting ge. This mol. should serve as a useful tool for studying Hedgehog signaling. This study involved multiple reactions and reactants, such as N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7SDS of cas: 315703-52-7).
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.SDS of cas: 315703-52-7
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica