Llona-Minguez, Sabin et al. published their research in Journal of Medicinal Chemistry in 2016 | CAS: 74704-39-5

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Quality Control of 4-(Bromomethyl)-2-methylthiazole

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1 was written by Llona-Minguez, Sabin;Hoeglund, Andreas;Jacques, Sylvain A.;Johansson, Lars;Calderon-Montano, Jose Manuel;Claesson, Magnus;Loseva, Olga;Valerie, Nicholas C. K.;Lundbaeck, Thomas;Piedrafita, Javier;Maga, Giovanni;Crespan, Emmanuele;Meijer, Laurent;Burgos Moron, Estefania;Baranczewski, Pawel;Hagbjoerk, Ann-Louise;Svensson, Richard;Wiita, Elisee;Almloef, Ingrid;Visnes, Torkild;Jeppsson, Fredrik;Sigmundsson, Kristmundur;Jensen, Annika Jenmalm;Artursson, Per;Jemth, Ann-Sofie;Stenmark, Paal;Warpman Berglund, Ulrika;Scobie, Martin;Helleday, Thomas. And the article was included in Journal of Medicinal Chemistry in 2016.Quality Control of 4-(Bromomethyl)-2-methylthiazole The following contents are mentioned in the article:

The dCTPase pyrophosphatase 1 (dCTPase) regulates the intracellular nucleotide pool through hydrolytic degradation of canonical and noncanonical nucleotide triphosphates (dNTPs). DCTPase is highly expressed in multiple carcinomas and is associated with cancer cell stemness. Here the authors report on the development of the first potent and selective dCTPase inhibitors that enhance the cytotoxic effect of cytidine analogs in leukemia cells. Boronate I displays a promising in vitro ADME profile, including plasma and mouse microsomal half-lives, aqueous solubility, cell permeability and CYP inhibition, deeming it a suitable compound for in vivo studies. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Quality Control of 4-(Bromomethyl)-2-methylthiazole).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Quality Control of 4-(Bromomethyl)-2-methylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica