Exploration of a simplified protocol for solid lipid nanoparticles production and characterization was written by Loureiro, Joana A.;Pereira, Maria C.. And the article was included in Journal of Chemical Education in 2021.Computed Properties of C20H18N2O2S The following contents are mentioned in the article:
Solid Lipid Nanoparticles (SLNs) are exciting nanoparticles used for transport therapeutic drugs into the organism. In this laboratory work, a simple experiment is performed to introduce master students into the field of nanotechnol., here applied to health including the applications in healthcare/pharmaceutical and cosmetic industry. This work demonstrates the advantages of SLNs as a vehicle to deliver/transport hydrophobic mols. The experiments are designed to be accomplished in two parts, i.e. two practical classes of 120 min each. In the first part, students will produce SLNs using homogenization followed by the ultrasonication method. In the second part, the SLNs will be characterized through their hydrodynamic size, polydispersity index, zeta potential and microscopically observed using a fluorescence microscope. Their encapsulation efficiency (EE) and loading capacity (LC) will be calculated This laboratory work could be performed in groups of two students. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Computed Properties of C20H18N2O2S).
3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Computed Properties of C20H18N2O2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica