Synthesis of Chiral Esters via Asymmetric Wolff Rearrangement Reaction was written by Meng, Jing;Ding, Wei-Wei;Han, Zhi-Yong. And the article was included in Organic Letters in 2019.Safety of (S)-2-Benzyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole The following contents are mentioned in the article:
The first asym. Wolff rearrangement reaction that directly converts α-diazoketones into broadly useful chiral α,α-disubstituted carboxylic esters with high enantioselectivities (up to 97.5:2.5 er) is reported. The cascade reaction proceeds through the seamless combination of visible-light-induced formation of the ketene intermediate and asym. ketene esterification using a readily available benzotetramisole-type catalyst. This study involved multiple reactions and reactants, such as (S)-2-Benzyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole (cas: 1239015-83-8Safety of (S)-2-Benzyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole).
(S)-2-Benzyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole (cas: 1239015-83-8) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Safety of (S)-2-Benzyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica