Day: November 28, 2022

Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues was written by Evers, Britta;Ruehter, Gerd;Berg, Martina;Dodge, Jeffrey A.;Hankotius, Dirk;Hary, Ulrike;Jungheim, Louis N.;Mest, Hans-Juergen;de la Nava, Eva-Maria Martin;Mohr, Michael;Muehl, Brian S.;Petersen, Soenke;Sommer, Birgit;Riedel-Herold, Grit;Tebbe, Mark J.;Thrasher, Kenneth J.;Voelkers, Silke. And the article was included in Bioorganic & Medicinal Chemistry in 2005.Related Products of 74704-39-5 The following contents are mentioned in the article:

A series of growth hormone secretagogues (GHSs) based on 2,3-dihydroisothiazole has been synthesized in the search for a potential treatment of growth hormone deficiency or frailty in the elderly. This paper describes the evaluation of the SAR of the benzyl-D-Ser-aminoisobutyric acid dipeptide fragment. Introduction of substituents in the peptide backbone and in the Ph ring has been investigated, as well as replacements for the benzyl group and for the AIB residue. A number of modifications resulted in enhanced potency over the parent benzyl-D-Ser-AIB derivative This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Related Products of 74704-39-5).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Related Products of 74704-39-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Signal transmission encryption based on dye-doped chiral liquid crystals via tunable and efficient circularly polarized luminescence was written by Li, Chengxi;Yang, Xuefeng;Han, Jianlei;Sun, Wenjing;Duan, Pengfei. And the article was included in Materials Advances in 2021.Recommanded Product: 38215-36-0 The following contents are mentioned in the article:

Multi-channel adjustable chiral liquid crystal materials with outstanding circularly polarized luminescence (CPL) have attracted lots of interest. Here, we demonstrate a coumarin 6 (C6) doped chiral liquid crystal, exhibiting crosstalk-free tunable CPL behavior by adjusting the component ratio and thickness. In the thickness study, when a double-layer structure was implemented, excellent CPL performance with a large dissymmetry factor (1.53) was observed in an optimal ratio. In particular, a rare chiroptical device using the obtained CPL as the input signal source was built to encrypt the signal transmission. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Recommanded Product: 38215-36-0).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 38215-36-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Multi-step application of immobilized reagents and scavengers: A total synthesis of epothilone C was written by Storer, R. Ian;Takemoto, Toshiyasu;Jackson, Philip S.;Brown, Dearg S.;Baxendale, Ian R.;Ley, Steven V.. And the article was included in Chemistry – A European Journal in 2004.Recommanded Product: 4-(Bromomethyl)-2-methylthiazole The following contents are mentioned in the article:

The total synthesis of the cytotoxic antitumor natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-supported reagents, catalysts, scavengers and catch-and-release techniques to avoid frequent aqueous work-up and chromatog. purification The enantioselective preparation of 3 key fragments heptanone I, (S)-2-methyl-6-heptenal, and thiazole II along with their elaboration via diastereoselective coupling into epothilone C is presented. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Recommanded Product: 4-(Bromomethyl)-2-methylthiazole).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Recommanded Product: 4-(Bromomethyl)-2-methylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1 was written by Llona-Minguez, Sabin;Hoeglund, Andreas;Jacques, Sylvain A.;Johansson, Lars;Calderon-Montano, Jose Manuel;Claesson, Magnus;Loseva, Olga;Valerie, Nicholas C. K.;Lundbaeck, Thomas;Piedrafita, Javier;Maga, Giovanni;Crespan, Emmanuele;Meijer, Laurent;Burgos Moron, Estefania;Baranczewski, Pawel;Hagbjoerk, Ann-Louise;Svensson, Richard;Wiita, Elisee;Almloef, Ingrid;Visnes, Torkild;Jeppsson, Fredrik;Sigmundsson, Kristmundur;Jensen, Annika Jenmalm;Artursson, Per;Jemth, Ann-Sofie;Stenmark, Paal;Warpman Berglund, Ulrika;Scobie, Martin;Helleday, Thomas. And the article was included in Journal of Medicinal Chemistry in 2016.Quality Control of 4-(Bromomethyl)-2-methylthiazole The following contents are mentioned in the article:

The dCTPase pyrophosphatase 1 (dCTPase) regulates the intracellular nucleotide pool through hydrolytic degradation of canonical and noncanonical nucleotide triphosphates (dNTPs). DCTPase is highly expressed in multiple carcinomas and is associated with cancer cell stemness. Here the authors report on the development of the first potent and selective dCTPase inhibitors that enhance the cytotoxic effect of cytidine analogs in leukemia cells. Boronate I displays a promising in vitro ADME profile, including plasma and mouse microsomal half-lives, aqueous solubility, cell permeability and CYP inhibition, deeming it a suitable compound for in vivo studies. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Quality Control of 4-(Bromomethyl)-2-methylthiazole).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Quality Control of 4-(Bromomethyl)-2-methylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

P53-induced reduction of lipid peroxidation supports brain microvascular endothelium integrity was written by Akhter, Mohammad S.;Uddin, Mohammad A.;Kubra, Khadeja-Tul;Barabutis, Nektarios. And the article was included in Journal of Pharmacological Sciences in 2019.Formula: C16H19BrN2OS The following contents are mentioned in the article:

Dysregulation of the blood brain barrier due to oxidative stress causes neurol. disorders, such as Alzheimer′s and Parkinson′s disease. We employed brain microvascular endothelial cells; to investigate the effects of P53 towards the lipid oxidation of the BBB. P53 reduction by LPS, siRNA for P53 and Pifithrin increased the expression levels of malondialdehyde, a marker of oxidative stress and lipid peroxidation Furthermore, P53 suppression impaired the permeability of the BBB monolayers. In contrast, P53 induction by Nutlin and Hsp90 inhibitor AUY922 enhanced the BBB function. In conclusion, P53 supports BBB integrity, at least in part, by reducing lipid peroxidation This study involved multiple reactions and reactants, such as 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2Formula: C16H19BrN2OS).

2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Formula: C16H19BrN2OS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Synthesis and Evaluation of Anticonvulsant Activities of Triazole- Incorporated Benzothiazoles was written by Song, Ming-Xia;Zeng, Hong;Deng, Xian-Qing;Quan, Zhe-Shan. And the article was included in Letters in Drug Design & Discovery in 2014.Safety of 6-Butoxybenzo[d]thiazol-2-amine The following contents are mentioned in the article:

A series of 6-alkoxy-2-(4H-1,2,4-triazol-4-yl)benzothiazoles was synthesized and evaluated for their anticonvulsant activity using the maximal electroshock (MES) method. Interestingly, all of the compounds prepared showed long duration of protection effect in the MES screens. And none of them, except compounds 4b and 4d, showed any neurotoxicity at dose of 300 mg/kg. Compound 4c was considered as the most promising one with an ED50 value of 39.4 mg/kg, and a superior PI value of 17.3 when compared to the marketed antiepileptic drugs carbamazepine, phenobarbital, and valproate. What’s more, compound 4c showed high protection against seizures induced by pentylenetetrazole. This study involved multiple reactions and reactants, such as 6-Butoxybenzo[d]thiazol-2-amine (cas: 14372-65-7Safety of 6-Butoxybenzo[d]thiazol-2-amine).

6-Butoxybenzo[d]thiazol-2-amine (cas: 14372-65-7) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Safety of 6-Butoxybenzo[d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

An infrared study of rotational isomerism in thiazole-2-carboxylates was written by Kaye, Perry T.;Meakins, G. Denis;Willbe, Charles;Williams, Peter R.. And the article was included in Journal of the Chemical Society in 1981.Reference of 79247-77-1 The following contents are mentioned in the article:

Twenty-five alkyl thiazole-2-carboxylates with a range of 4- and 5-substituents were prepared through the Hantzsch synthesis. E.g., cyclocondensation reaction of (H₂N)₂CS with MeCOCH₂Br followed by bromination, oxidation, and alkylation gave the thiazole esters I (R = Me, Et). Solutions of these esters show well resolved doublets in the carbonyl IR spectra, due to rotational isomers. The higher wave number components were assigned to the more polar carbonyl O,S-anti-s-trans rotamers and those at lower wave number to the O,S-syn-s-trans forms. Small, but systematic, differences between the Me esters were noted. This study involved multiple reactions and reactants, such as 5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide (cas: 79247-77-1Reference of 79247-77-1).

5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide (cas: 79247-77-1) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Reference of 79247-77-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Tumour suppressor p53 inhibits hepatitis C virus replication by inducing E6AP -mediated proteasomal degradation of the viral core protein was written by Park, Ji-Min;Yoon, Hyunyoung;Jeong, Yuna;Jang, Kyung Lib. And the article was included in FEBS Letters in 2022.HPLC of Formula: 63208-82-2 The following contents are mentioned in the article:

The tumor suppressor p53 has been implicated in the host defense system against hepatitis C virus (HCV) infection, although the detailed mechanism remains unknown. Here, we found that p53 inhibits HCV replication by downregulating HCV Core protein levels in human hepatoma cells. For this effect, p53 potentiated the role of E6-associated protein (E6AP) as an E3 ligase to induce ubiquitination and proteasomal degradation of HCV Core. Specifically, p53 facilitated the binding of E6AP to HCV Core through direct interactions with the two proteins. In addition, E6AP failed to induce ubiquitination of HCV Core in the absence of p53, suggesting that p53 increases the E3 ligase activity of E6AP in a triple complex consisting of p53, E6AP and HCV Core. This study involved multiple reactions and reactants, such as 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2HPLC of Formula: 63208-82-2).

2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.HPLC of Formula: 63208-82-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Pseudomonas aeruginosa porphobilinogen synthase assembly state regulators: hit discovery and initial SAR studies was written by Reitz, Allen B.;Ramirez, Ursula D.;Stith, Linda;Du, Yanming;Smith, Garry R.;Jaffe, Eileen K.. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2010.Reference of 74704-39-5 The following contents are mentioned in the article:

Porphobilinogen synthase (PBGS) catalyzes the first common step in the biosynthesis of the essential heme, chlorophyll and vitamin B₁₂ heme pigments. PBGS activity is regulated by assembly state, with certain oligomers exhibiting biol. activity and others either partially or completely inactive, affording an innovative means of allosteric drug action. Pseudomonas aeruginosa PBGS is functionally active as an octamer, and inactive as a dimer. We have identified a series of compounds that stabilize the inactive P. aeruginosa dimer by a computational prescreen followed by native PAGE gel mobility shift anal. From those results, we have prepared related thiadiazoles and evaluated their ability to regulate P. aeruginosa PBGS assembly state. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Reference of 74704-39-5).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Reference of 74704-39-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Pickering emulsions stabilized by ultrashort nanotubes was written by Meng, H.;Du, D.. And the article was included in Materials Today Chemistry in 2021.Safety of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one The following contents are mentioned in the article:

We describe a simple method to prepare high-efficiency ultrashort nanotube Pickering emulsifiers. The polydivinylbenzene (PDVB) nanotubes with a slight degree of sulfonation, then interrupted to several microns in length, can stabilize hundred times their own mass of oil or water phase and form different Pickering emulsion types. The emulsion is very stable and can be stored for more than half a year without demulsification. A layer of magnetic Fe₃O₄ nanoparticles can be grown on the surface of the ultrashort sulfonated PDVB nanotubes. After being emulsified, oil-phase and magnetic nanotubes can be collected using a magnet, which have huge potential application for separation and recovery of organic solvents in environmental protection. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Safety of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Safety of 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica