Day: November 28, 2022

Kinetic Resolution of Racemic α-Arylalkanoic Acids with Achiral Alcohols via the Asymmetric Esterification Using Carboxylic Anhydrides and Acyl-Transfer Catalysts was written by Shiina, Isamu;Nakata, Kenya;Ono, Keisuke;Onda, Yu-suke;Itagaki, Makoto. And the article was included in Journal of the American Chemical Society in 2010.SDS of cas: 1239015-83-8 The following contents are mentioned in the article:

A variety of optically active carboxylic esters are produced by the kinetic resolution of racemic α-substituted carboxylic acids using achiral alcs., aromatic or aliphatic carboxylic anhydrides, and chiral acyl-transfer catalysts. The combination of 4-methoxybenzoic anhydride (PMBA) or pivalic anhydride with the modified benzotetramisole-type catalyst, I, is the most effective for promotion of the enantioselective coupling reaction between racemic carboxylic acids and a novel nucleophile, bis(α-naphthyl)methanol, to give the corresponding esters, e.g. II, with high ee’s. This protocol was successfully applied to the production of nonracemic nonsteroidal anti-inflammatory drugs from racemic compounds utilizing the transacylation process to generate the mixed anhydrides from the acid components with the suitable carboxylic anhydrides. This study involved multiple reactions and reactants, such as (S)-2-Benzyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole (cas: 1239015-83-8SDS of cas: 1239015-83-8).

(S)-2-Benzyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole (cas: 1239015-83-8) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.SDS of cas: 1239015-83-8

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Role of JNK and p53 in Implementation of Functions of Various Types of Regeneration-Competent Cells of the Nervous Tissue was written by Zyuz’kov, G. N.;Zhdanov, V. V.;Miroshnichenko, L. A.;Polyakova, T. Yu.;Simanina, E. V.;Stavrova, L. A.;Danilets, M. G.;Agafonov, V. I.;Chaikovskii, A. V.. And the article was included in Bulletin of Experimental Biology and Medicine in 2021.Related Products of 63208-82-2 The following contents are mentioned in the article:

We studied the participation of JNK and p53 in the realization of the growth potential of different types of progenitors of the subventricular zone of mouse brain and secretion of neurotrophins by glial cells. The stimulating role of these signaling mols. in mitotic activity and specialization of multipotent neural stem cells was shown. It was found that JNK and p53 do not participate in the regulation of committed neuronal progenitor cells (clonogenic PSA-NCAM+ cells). A dependence of neurotrophic growth factors in individual populations of neuroglia on activity of these protein kinase and transcription factor was revealed. The role of JNK and p53 in astrocytes consists in stimulation of their secretion, and in microglial cells, on the contrary, in its inhibition. The secretory neurotrophic function of oligodendrogliocytes is not associated with JNK and p53 activity. This study involved multiple reactions and reactants, such as 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2Related Products of 63208-82-2).

2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Related Products of 63208-82-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Large-scale screening of molecules involved in virus-host interaction by specific compounds in Cherax quadricarinatus hematopoietic tissue cells was written by Lin, Wenyang;Guo, Guangran;Zou, Chenchen;Shi, Hong;Ruan, Lingwei. And the article was included in Aquaculture in 2020.Synthetic Route of C16H19BrN2OS The following contents are mentioned in the article:

White spot syndrome virus is one of the major pathogens that seriously threaten crustacean aquaculture. However, knowledge about the mol. mechanism of virus-host interaction remains limited. In the present study, a library containing 303 compounds targeting specific mols. was used for large-scale screening for the first time. Cherax quadricarinatus hematopoietic tissue cells were used in the present study. Combining the anal. of viral infection and cell toxicity test, 30 compounds were demonstrated to be effective. Their targeted mols. were involved in the regulation of a variety of cell signaling pathways and participated in several cellular processes, such as Hedgehog and NF-κB cell signaling pathway and regulation of cellular ions. The present study provides valuable insights into the mol. mechanism of the viral pathogenesis and host immunity, and will help to advance disease control. This study involved multiple reactions and reactants, such as 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2Synthetic Route of C16H19BrN2OS).

2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Synthetic Route of C16H19BrN2OS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Large-scale screening of molecules involved in virus-host interaction by specific compounds in Cherax quadricarinatus hematopoietic tissue cells was written by Lin, Wenyang;Guo, Guangran;Zou, Chenchen;Shi, Hong;Ruan, Lingwei. And the article was included in Aquaculture in 2020.Related Products of 315703-52-7 The following contents are mentioned in the article:

White spot syndrome virus is one of the major pathogens that seriously threaten crustacean aquaculture. However, knowledge about the mol. mechanism of virus-host interaction remains limited. In the present study, a library containing 303 compounds targeting specific mols. was used for large-scale screening for the first time. Cherax quadricarinatus hematopoietic tissue cells were used in the present study. Combining the anal. of viral infection and cell toxicity test, 30 compounds were demonstrated to be effective. Their targeted mols. were involved in the regulation of a variety of cell signaling pathways and participated in several cellular processes, such as Hedgehog and NF-κB cell signaling pathway and regulation of cellular ions. The present study provides valuable insights into the mol. mechanism of the viral pathogenesis and host immunity, and will help to advance disease control. This study involved multiple reactions and reactants, such as N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7Related Products of 315703-52-7).

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Related Products of 315703-52-7

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

A Spider-Silk-Inspired Wet Adhesive with Supercold Tolerance was written by Liu, Xi;Shi, Lianxin;Wan, Xizi;Dai, Bing;Yang, Man;Gu, Zhen;Shi, Xinghua;Jiang, Lei;Wang, Shutao. And the article was included in Advanced Materials (Weinheim, Germany) in 2021.Name: 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one The following contents are mentioned in the article:

Conventional adhesives often encounter interfacial failure in humid conditions due to small droplets of water condensed on surface, but spider silks can capture prey in such environment. Here a robust spider-silk-inspired wet adhesive (SA) composed of core-sheath nanostructured fibers with hygroscopic adhesive nanosheath (poly(vinylpyrrolidone)) and supporting nanocore (polyurethane) is reported. The wet adhesion of the SA is achieved by a unique dissolving-wetting-adhering process of core-sheath nanostructured fibers, revealed by in situ observations at macro- and microscales. Further, the SA maintains reliable adhesion on wet and cold substrates from 4 to -196°C and even tolerates splashing, violent shaking, and weight loading in liquid nitrogen (-196°C), showing promising applicability in cryogenic environments. This study will provide an innovative route to design functional wet adhesives. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Name: 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Name: 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents was written by Zhao, Shizhen;Zhao, Liyu;Zhang, Xiangqian;Liu, Chunchi;Hao, Chenzhou;Xie, Honglei;Sun, Bin;Zhao, Dongmei;Cheng, Maosheng. And the article was included in European Journal of Medicinal Chemistry in 2016.HPLC of Formula: 479028-67-6 The following contents are mentioned in the article:

A series of compounds with benzothiazole and amide-imidazole scaffolds were designed and synthesized to combat the increasing incidence of drug-resistant fungal infections. The antifungal activity of these compounds was evaluated in vitro, and their structure-activity relationships (SARs) were evaluated. The synthesized compounds showed excellent inhibitory activity against Candida albicans and Cryptococcus neoformans. The most potent compounds I (R¹ = 6-Br, 6-CF₃; R² = ipr, ibu) exhibited potent activity, with min. inhibitory concentration (MIC) values in the range of 0.125-2 μg/mL. Preliminary mechanism studies revealed that the compound I (R¹ = 6-Br, R² = ibu) might act by inhibiting the CYP51 of Candida albicans. The SARs and binding mode established in this study are useful for further lead optimization. This study involved multiple reactions and reactants, such as 6-Fluorobenzo[d]thiazole-2-carboxylic acid (cas: 479028-67-6HPLC of Formula: 479028-67-6).

6-Fluorobenzo[d]thiazole-2-carboxylic acid (cas: 479028-67-6) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.HPLC of Formula: 479028-67-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Tailoring C-6-Substituted Coumarin Scaffolds for Novel Photophysical Properties and Stimuli-Responsive Chromism was written by Singh, Ravinder;Chen, Deng-Gao;Wang, Chun-Hsiang;Lan, Yi-Cheng;Liu, Yi-Hung;Chou, Pi-Tai;Chen, Chao-Tsen. And the article was included in Journal of Physical Chemistry B in 2021.COA of Formula: C20H18N2O2S The following contents are mentioned in the article:

A judicious strategy was utilized to envision the substantial regio-positional effects of substituents on the photophys. properties of the 2H-chromen-2-one-3-benzothiazole scaffold-based push-pull framework, named 6-X-CUMs. Among them, 6-NEt₂-CUM reveals prominent excited-state intramol. charge transfer with a large change of dipole moment (Δμ ~18.23 D), hence displaying remarkable emission solvatochromism from the green (536 nm in cyclohexane) to far-red region (714 nm in DMSO) and a high-temperature sensitivity (-0.23 nm °C^-1). These, together with unique basicity and acido-/vaporchromism upon acidification elucidated by NMR and photospectroscopic studies, show stark contrast to the conventional 7-NEt₂-CUM. The new series of these tailored 6-X-CUMs represents a new dimension in tailoring the photophys. properties for the development of a promising class of multistimuli-responsive materials. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0COA of Formula: C20H18N2O2S).

3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.COA of Formula: C20H18N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Age-related dysfunction of p53-regulated phagocytic activity in macrophages was written by Yamaguchi, Yohko;Kaida, Kohei;Suenaga, Yusuke;Ishigami, Akihito;Kobayashi, Yoshiro;Nagata, Kisaburo. And the article was included in Biochemical and Biophysical Research Communications in 2020.Related Products of 63208-82-2 The following contents are mentioned in the article:

Aging promotes polarization of M2-like macrophages to M1-like macrophages and reduces their phagocytic ability. However, the mol. mechanisms underlying these aging-related changes remain poorly understood. Here, we demonstrate that p53 regulates phagocytic activity in macrophages from young mice but not in those from old ones. Macrophages from both old and young mice expressed functional p53 to induce target genes including p21 and Mdm2. In macrophages from young mice, chem. induced p53 decreased phagocytic activity and c-Myc levels, with the latter change reducing M2-related genes. However, in macrophages from old mice, phagocytic activity and c-Myc expression were independent of p53 activity. Furthermore, c-Myc suppression did not affect M2-related genes in old-mouse macrophages. These results demonstrate that dysregulation of p53 function is a mol. mechanism underlying reduced phagocytic activity in aged-mouse macrophages. This study involved multiple reactions and reactants, such as 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2Related Products of 63208-82-2).

2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Related Products of 63208-82-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH) was written by Tully, David C.;Rucker, Paul V.;Chianelli, Donatella;Williams, Jennifer;Vidal, Agnes;Alper, Phil B.;Mutnick, Daniel;Bursulaya, Badry;Schmeits, James;Wu, Xiangdong;Bao, Dingjiu;Zoll, Jocelyn;Kim, Young;Groessl, Todd;McNamara, Peter;Seidel, H. Martin;Molteni, Valentina;Liu, Bo;Phimister, Andrew;Joseph, Sean B.;Laffitte, Bryan. And the article was included in Journal of Medicinal Chemistry in 2017.HPLC of Formula: 225525-63-3 The following contents are mentioned in the article:

The farnesoid X receptor (FXR) is a nuclear receptor that acts as a master regulator of bile acid metabolism and signaling. Activation of FXR inhibits bile acid synthesis and increases bile acid conjugation, transport, and excretion, thereby protecting the liver from the harmful effects of bile accumulation, leading to considerable interest in FXR as a therapeutic target for the treatment of cholestasis and nonalcoholic steatohepatitis. We identified a novel series of highly potent non-bile acid FXR agonists that introduce a bicyclic nortropine-substituted benzothiazole carboxylic acid moiety onto a trisubstituted isoxazole scaffold. Herein, we report the discovery of 1 (tropifexor, LJN452), a novel and highly potent agonist of FXR. Potent in vivo activity was demonstrated in rodent PD models by measuring the induction of FXR target genes in various tissues. Tropifexor has advanced into phase 2 human clin. trials in patients with NASH and PBC. This study involved multiple reactions and reactants, such as Methyl 2-amino-4-methylbenzo[d]thiazole-6-carboxylate (cas: 225525-63-3HPLC of Formula: 225525-63-3).

Methyl 2-amino-4-methylbenzo[d]thiazole-6-carboxylate (cas: 225525-63-3) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.HPLC of Formula: 225525-63-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

VPA and TSA Interrupt the Interplay between mutp53 and HSP70, Leading to CHK1 and RAD51 Down-Regulation and Sensitizing Pancreatic Cancer Cells to AZD2461 PARP Inhibitor was written by Romeo, Maria Anele;Gilardini Montani, Maria Saveria;Benedetti, Rossella;Arena, Andrea;D’Orazi, Gabriella;Cirone, Mara. And the article was included in International Journal of Molecular Sciences in 2022.Related Products of 63208-82-2 The following contents are mentioned in the article:

HDAC inhibitors (HDACi) represent promising anti-cancer treatments, as the acetylation of histone and non-histone proteins is often dysregulated in cancer and contributes to cancer onset and progression. HDACi have been also reported to increase the cytotoxicity of DNA-damaging agents, such as radiation or cisplatin. In this study, we found that TSA and, even more effectively, VPA synergized with AZD2461, PARP1, 2 and 3 inhibitor (PARPi) to induce DNA damage and reduce pancreatic cancer cell survival. At a mol. level, VPA and TSA down-regulated CHK1 and RAD51, which is correlated with the interruption of the cross-talk between mutp53 and HSP70. Moreover, VPA and to a lesser extent TSA reactivated wtp53 in these cells, which contributed to CHK1 and RAD51 reduction These findings suggest that the combination of HDACi and PARPi might improve the treatment of pancreatic cancer, which remains one of the most aggressive and therapy-resistant cancers. This study involved multiple reactions and reactants, such as 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2Related Products of 63208-82-2).

2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Related Products of 63208-82-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica