TBHP/AIBN-Mediated Synthesis of 2-Amino-thiazoles from Active Methylene Ketones and Thiourea under Metal-free Conditions was written by Sun, Jiyun;Ge, Huaibin;Zhen, Xiaohua;An, Xuechan;Zhang, Guangtao;Zhang-Negrerie, Daisy;Du, Yunfei;Zhao, Kang. And the article was included in Tetrahedron in 2018.Product Details of 303994-99-2 The following contents are mentioned in the article:
A new oxidative system of tert-Bu hydroperoxide (TBHP)/azodiisobutyronitrile (AIBN) was used for the first time for a convenient, metal-free synthesis of substituted 2-aminothiazoles from active methylene ketone derivatives and thiourea. The reaction was postulated to proceed via an oxidative cyclization initiated by a radical process and followed by a condensation reaction. This study involved multiple reactions and reactants, such as 2-Amino-4-(tert-butyl)thiazole-5-carbonitrile (cas: 303994-99-2Product Details of 303994-99-2).
2-Amino-4-(tert-butyl)thiazole-5-carbonitrile (cas: 303994-99-2) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Product Details of 303994-99-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica