Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents was written by Zhao, Shizhen;Zhao, Liyu;Zhang, Xiangqian;Liu, Chunchi;Hao, Chenzhou;Xie, Honglei;Sun, Bin;Zhao, Dongmei;Cheng, Maosheng. And the article was included in European Journal of Medicinal Chemistry in 2016.HPLC of Formula: 479028-67-6 The following contents are mentioned in the article:
A series of compounds with benzothiazole and amide-imidazole scaffolds were designed and synthesized to combat the increasing incidence of drug-resistant fungal infections. The antifungal activity of these compounds was evaluated in vitro, and their structure-activity relationships (SARs) were evaluated. The synthesized compounds showed excellent inhibitory activity against Candida albicans and Cryptococcus neoformans. The most potent compounds I (R1 = 6-Br, 6-CF3; R2 = ipr, ibu) exhibited potent activity, with min. inhibitory concentration (MIC) values in the range of 0.125-2 μg/mL. Preliminary mechanism studies revealed that the compound I (R1 = 6-Br, R2 = ibu) might act by inhibiting the CYP51 of Candida albicans. The SARs and binding mode established in this study are useful for further lead optimization. This study involved multiple reactions and reactants, such as 6-Fluorobenzo[d]thiazole-2-carboxylic acid (cas: 479028-67-6HPLC of Formula: 479028-67-6).
6-Fluorobenzo[d]thiazole-2-carboxylic acid (cas: 479028-67-6) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.HPLC of Formula: 479028-67-6
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica