Bodireddy, Mohan Reddy published the artcileLactic acid-mediated tandem one-pot synthesis of 2-aminothiazole derivatives: a rapid, scalable, and sustainable process, Application of 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Cogent Chemistry (2016), 2(1), 1154237/1-1154237/13, database is CAplus.
Environmentally benign and biodegradable lactic acid was identified as alternative solvent and catalyst for the tandem one-pot synthesis of Hantzsch 2-aminothiazole derivatives from readily available aralkyl ketones through in-situ regioselective α-bromination using N-bromosuccinimide followed by heterocyclization using thiourea at 90-100°. The major advantages of the present method include short reaction times (10-15 min), practical, simple to perform, easy work-up, good yield of products (up to 96%), productive for large-scale applications, free from apply of α-bromoketones (lachrymator) as substrates, avoids column purification Hence, the present method met with the concepts of both Wender’s “ideal synthesis” and sustainable chem. process.
Cogent Chemistry published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Application of 4-(Naphthalen-1-yl)thiazol-2-amine.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica