Buckley, Dennis L. published the artcileHaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins, Formula: C11H8N2OS, the publication is ACS Chemical Biology (2015), 10(8), 1831-1837, database is CAplus and MEDLINE.
Small mol.-induced protein degradation is an attractive strategy for the development of chem. probes. One method for inducing targeted protein degradation involves the use of PROTACs, heterobifunctional mols. that can recruit specific E3 ligases to a desired protein of interest. PROTACs have been successfully used to degrade numerous proteins in cells, but the peptidic E3 ligase ligands used in previous PROTACs have hindered their development into more mature chem. probes or therapeutics. The authors report the design of a novel class of PROTACs that incorporate small mol. VHL ligands to successfully degrade HaloTag7 fusion proteins. These HaloPROTACs will inspire the development of future PROTACs with more drug-like properties. Addnl., these HaloPROTACs are useful chem. genetic tools, due to their ability to chem. knock down widely used HaloTag7 fusion proteins in a general fashion.
ACS Chemical Biology published new progress about 1448190-10-0. 1448190-10-0 belongs to thiazole, auxiliary class Thiazoles, name is 2-Hydroxy-4-(4-methylthiazol-5-yl)benzonitrile, and the molecular formula is C11H8N2OS, Formula: C11H8N2OS.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica