Day: November 29, 2022

Chalmpes, Nikolaos published the artcileGraphene oxide-cytochrome C multilayered structures for biocatalytic applications: Role of surfactant in Langmuir-Schaefer layer deposition, Recommanded Product: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is ACS Applied Materials & Interfaces (2022), 14(22), 26204-26215, database is CAplus and MEDLINE.

Graphene, a two-dimensional single-layer carbon allotrope, has attracted tremendous scientific interest due to its outstanding physicochem. properties. Its monat. thickness, high sp. surface area, and chem. stability render it an ideal building block for the development of well-ordered layered nanostructures with tailored properties. Herein, biohybrid graphene-based layer-by-layer structures are prepared by means of conventional and surfactant-assisted Langmuir-Schaefer layer deposition techniques, whereby cytochrome C mols. are accommodated within ordered layers of graphene oxide. The biocatalytic activity of the as-developed nanobio-architectures toward the enzymic oxidation of 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt and decolorization of pinacyanol chloride is tested. The results show that the multilayer structures exhibit high biocatalytic activity and stability in the absence of surfactant mols. during the deposition of the monolayers.

ACS Applied Materials & Interfaces published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Recommanded Product: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Shaikh, Asif R. published the artcileAntimycobacterial and antimicrobial studies of newly synthesized 3-(4-(6-methylbenzo[d]thiazol-2-yl) phenyl)quinazolin-4(3H)-ones, HPLC of Formula: 92-36-4, the publication is Indian Journal of Research in Pharmacy and Biotechnology (2014), 2(1), 935-942, 8 pp., database is CAplus.

The 7-chloro-2-(substituted)-3-(4-(6-methylbenzo[d]thiazol-2-yl)phenyl) quinazolin-4(3H)-ones e.g., I (R = furan-2-yl) have been prepared from the substituted acids, which were converted to substituted acetyl chlorides and cyclized with 4-chloro anthranilic acid afforded substituted benzoxazines 4(3H)-ones e.g., II and its further reaction with 4-(6-methylbenzo[d]thiazol-2-yl)aniline a gives desired compounds I. In vitro antitubercular activity was carried out against Mycobacterium tuberculosis H₃₇Rv strain using Lowenstein-Jensen medium (conventional method) and antimicrobial activity against various bacteria and fungi using broth microdilution method. The compounds II, I were emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antituberculars. The compounds II, I showed better antitubercular activities compared to rifampicin and isoniazid.

Indian Journal of Research in Pharmacy and Biotechnology published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C7H6Cl2, HPLC of Formula: 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Gorjanovic, Stanislava Z. published the artcileSerbian aromatized wine “Bermet”: electrochemical, chemiluminescent and spectrophotometric determination of antioxidant activity, SDS of cas: 30931-67-0, the publication is Journal of the Serbian Chemical Society (2020), 85(4), 517-529, database is CAplus.

Serbian aromatized wine “Bermet” from grapes grown on Fruska Gora Mountain has been in production since the 15th century. Ten com. Bermets produced according to the traditional procedure by different manufacturers, and six prepared within the scope of this study were assessed for antioxidant (AO) activity using electrochem., chemiluminescent and spectrophotometric AO assays. D.c. polarog. assay based on the decrease of anodic current of [hydrogen(peroxido)(1-)]hydroxidomercury(II) complex formation in alk. H₂O₂ solution at potential of mercury oxidation, chemiluminescent H₂O₂ scavenging assay, as well as commonly used spectrophotometric assays (2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) based Trolox equivalent antioxidant capacity (TEAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP)) were used. Total phenolic content (TPC) was determined by Folin-Ciocalteu assay. The results obtained were correlated using regression anal., ANOVA and F-test. An integrated approach to AO capacity determination allowed a more comprehensive comparison between samples. The approach is based on the introduction of the relative antioxidant capacity index, calculated by assigning each AO assay equal weight, and by PCA anal. In addition, the introduction of phenolic antioxidant coefficients, calculated as the ratio between individual AO capacity and TPC, enabled a better understanding of their relation.

Journal of the Serbian Chemical Society published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, SDS of cas: 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Mendes, Sophia F. published the artcileUltrafiltration process for lignin-lean black liquor treatment at different acid conditions, Related Products of thiazole, the publication is Separation Science and Technology (Philadelphia, PA, United States) (2022), 57(12), 1936-1947, database is CAplus.

Black liquor treatment by acid precipitation produces two main streams: the high purity precipitated lignin and the lignin-lean black liquor (a diluted lignin solution). Here, we evaluated the ultrafiltration process for lignin recovery from lignin-lean black liquor at different pH values (9.0, 9.5 and 10.0). The ultrafiltration process was able to retain 83 ± 0.5% of lignin from the lignin-lean black liquor at pH 9.0. The permeate flux increased with the decrease in pH value (steady state flux of 5.3 ± 0.0 L h-1m-2 at pH 9.0). Cake formation was the main fouling occurrence during lignin-lean black liquor filtrations. The weight average mol. weight of the lignin-lean black liquor decreased from 1866 to 1208 Da after the ultrafiltration process. The pH value did not significantly influence the mol. weight of permeate stream. Permeate samples presented lower hydroxyl content and higher syringyl(S):guaiacyl(G) ratios than feed samples. Thus, the ultrafiltration process was able to concentrate lignin from the lignin-lean black liquor and to produce a permeate with a narrow mol. weight distribution. The precipitation at more acid conditions is suggested to improve permeate flux lignin retention from lignin-lean black liquor.

Separation Science and Technology (Philadelphia, PA, United States) published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Yang, Jung-Eun published the artcileSkin-protective and anti-inflammatory effects of Hibiscus syriacus L. (Mugunghwa): a comparative study of five parts of the plant, HPLC of Formula: 30931-67-0, the publication is Pharmacognosy Magazine (2020), 16(67), 183-191, database is CAplus.

Aim: The skin barrier is vulnerable to internal and external elements. However, certain plant extracts have promise for protecting the skin. Hibiscus syriacus L. is a Korean national plant (mugunghwa) that has been traditionally used to treat some skin diseases; however, its pharmacol. activities are poorly understood. The present study has evaluated the skin-protective effect of mugunghwa flowers (MF), cortexes (MC), roots (MR), leaves (ML), and seeds (MS) in external factor-stimulated human epidermal keratinocytes (HaCaTs), normal human dermal fibroblasts (NHDFs), and a widely used murine macrophage cell line (RAW 264.7 cells). Materials and Methods and Results: The active components were identified as palmitic acid and linoleic acid by high-performance liquid chromatog. anal. The parts of mugunghwa had low 2,2-diphenyl-1-picrylhydrazyl scavenging activities but moderate 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt scavenging capacity. All parts’ extracts at 100μg/mL decreased nitric oxide production in inflammation-induced RAW 264.7 cells and mRNA expression of the cytokines interleukin-6/1β and the enzymes inducible nitric oxide synthase/cyclooxygenase-2. On HaCaTs, MF, MC, and MR (10-50μg/mL) significantly increased hyaluronan production over that of controls. Moreover, MF activated NAD (P) H:quinone oxidoreductase 1 and heme oxygenase-1 and inhibited intracellular reactive oxygen species production Treatment with MF, MC, MR, ML, and MS (10μg/mL) reduced the scratching wound site in NHDFs to be considered by vascular endothelial growth factor signaling activation. Conclusion: Taken together, among all the five parts of the mugunghwa plant, MF effectively inhibited lipopolysaccharide, UV B irradiation, and scratching wound-induced inflammation in skin cells.

Pharmacognosy Magazine published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C9H7NO2, HPLC of Formula: 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Chung, Byung-Ho published the artcileSynthesis and biological evaluation of new allylamine antimycotics, Category: thiazole, the publication is Yakhak Hoechi (1996), 40(5), 507-512, database is CAplus.

Benzothiazolyl-substituted allylamines were prepared as potential antimycotics. Thus, intermediate Schiff bases, obtained by condensation of 2-aminobenzothiazoles and trans-cinnamaldehyde, were reduced and then methylated to give the benzothiazolyl-substituted allylamines. These compounds, which were tested in vitro against five fungal cell lines containing Trichophyton mentagrophytes, showed no activity in the 0.1-100 μg/mL range.

Yakhak Hoechi published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Huddar, Srigouri published the artcileDiscovery of 4-hydroxy-2-oxo-1,2-dihydroquinolines as potential inhibitors of Streptococcus pneumoniae, including drug-resistant strains, SDS of cas: 95-24-9, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(9), 127071, database is CAplus and MEDLINE.

New therapies for treating drug-resistant pneumococcal infections are urgently needed. The novel scaffold 6-hydroxy-4-oxo-1,2-dihydro-4H-quinoline was shown to have similar efficacies against all three different serotypes of S. pneumoniae, ATCC 49617 (19F), ATCC BAA-1663 (15B), and ATCC 700904 (19A), in a resazurin-based high-throughput screen using the Korea Chem. Bank library. Further studies to identify a new lead with this scaffold, including tricyclic pyrrolo[3,2,1-ij]quinolone and pyrido[3,2,1-ij]quinolone derivatives, led to the identification of 6d, 7d and 12a. Compound 6d (IC₅₀ = 0.92, 0.75, and 0.77μM), 7d (IC₅₀ = 0.57, 0.66, and 0.38μM) and 12a() (IC₅₀ = 0.27, 1.03, and 0.62μM) showed submicromolar IC₅₀ values against 19F, 15B, and 19A, resp., and thus serve as a starting point for further optimization. While some of compounds in this series exhibited acceptable pharmacokinetic profiles in preliminary in vivo rat experiments, the most active compound 12a showed poor solubility and high plasma protein binding. Our current research efforts are focused on optimizing compounds to improve physicochem. properties as well as potency.

Bioorganic & Medicinal Chemistry Letters published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, SDS of cas: 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Prajapat, Prakash published the artcileSynthesis of biologically potent alkoxyphthalimido plugged N-(2,4-dioxo-1,4-dihydroquinazolin)-3(2H)-yl)-4-oxo-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamide via Gould Jacobs reaction, Recommanded Product: 6-Chlorobenzothiazol-2-ylamine, the publication is Heterocyclic Letters (2021), 11(1), 63-72, database is CAplus.

Convenient methods for the synthesis of new alkoxyphthalimidoquinazolinedione and their pyrimidobenzothiazole derivatives I [R¹ = H, Cl, O₂N; R² = H, 2-(1,3-dioxoisoindolin-2-yl)oxyethyl] were reported. A series of benzothiazolopyrimidine-3-carboxamides I were prepared starting from substituted 2-aminobenzothiazoles via solvent free multi-component Gould-Jacobs reaction. Structures of newly synthesized compounds were established based on IR, ¹H-NMR, mass, anal. studies and fluorescence tests. Some of synthesized mols. I were assayed for their antimalarial activity. IC₅₀ values of antimalarial activity of compounds were also determined

Heterocyclic Letters published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Recommanded Product: 6-Chlorobenzothiazol-2-ylamine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Jakopec, Silvio published the artcileFerrocene conjugates linked by 1,2,3-triazole and their Zn(II) and Cu(II) complexes: Synthesis, characterization and biological activity, Recommanded Product: 6-Chlorobenzothiazol-2-ylamine, the publication is Applied Organometallic Chemistry (2022), 36(4), e6575, database is CAplus.

Ferrocene derivatives with mono- Py₂NCH₂Trz-1-R (8a–c; Py = 2-pyridyl, Trz = 1,2,3-triazol-5-yl; R = Fc, FcCH₂, FcCHMe) and bis-1,2,3-triazolyl fc(CH₂-1-TrzCH₂NPy₂)₂(9, fc = 1,1′-ferrocenediyl) and ArN(CH₂Trz-1-R)₂ (10a–13c; R = Fc, FcCH₂, FcCHMe; Ar = Ph, 2-benzothiazolyl, 6-chloro-2-benzothiazolyl, 6-nitro-2-benzothiazolyl) chelating groups were synthesized by regioselective copper(I)-catalyzed 1,3-dipolar cycloaddition of terminal alkynes with ferrocene azides. Metal complexes of the ligands were prepared with Cu(II) and Zn(II) salts. Crystal structures of ligands 9 and 11a were determined, as well as the structures of complexes [Cu(8a)₂](CF₃SO₃)₂ (8a-Cu) and [Cu(8c)₂(MeOH)₂](BF₄)₂ (8c-Cu). In addition to NMR and UV-Vis spectroscopy, the metal complexes were characterized by cyclic voltammetry. The cytotoxic effect of ferrocene conjugates and their Zn(II) and Cu(II) complexes was explored, and cell cycle anal. was performed. The complex [Cu(8c)₂](CF₃SO₃)₂ showed the most prominent and selective cytotoxicity on cervical carcinoma (HeLa), ovarian cancer (MES-OV), non-small cell lung cancer (A549) and breast carcinoma (MDA-MB-231) cells. This complex increased cell population in the S and G₂/M phase of the cell cycle, which was accompanied by an increase of the cells present in the sub-G₀/G₁ fraction.

Applied Organometallic Chemistry published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Recommanded Product: 6-Chlorobenzothiazol-2-ylamine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Bolchi, Cristiano published the artcileThiazole- and imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase, Recommanded Product: Methyl 2-(2-aminothiazol-4-yl)acetate, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(18), 5408-5412, database is CAplus and MEDLINE.

Mimetics of the C-terminal CAAX tetrapeptide of Ras protein were designed replacing internal dipeptide AA with 4-amino-2-phenylbenzoic acid and cysteine (C) with 2-amino-4-thiazolyl-, 2-mercapto-4-thiazolyl-, 2-mercapto-4-imidazolyl- and 2-methylmercapto-4-thiazolyl-acetic or propionic acid. The compound in which C is replaced by 2-amino-4-thiazolylacetic acid inhibited FTase activity in the low nanomolar range and showed antiproliferative effect on rat aortic smooth muscle cells interfering with Ras farnesylation. On the basis of these results, 2-aminothiazole can be considered as an alternative to heterocycles, such as pyridine and imidazole, normally used in FTase inhibitors designed as non-thiol CAAX mimetics.

Bioorganic & Medicinal Chemistry Letters published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C6H8N2O2S, Recommanded Product: Methyl 2-(2-aminothiazol-4-yl)acetate.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica