Day: November 29, 2022

Tran, Tai Duc published the artcileDNA-copper hybrid nanoflowers as efficient laccase mimics for colorimetric detection of phenolic compounds in paper microfluidic devices, Formula: C18H24N6O6S4, the publication is Biosensors & Bioelectronics (2021), 113187, database is CAplus and MEDLINE.

Laccases are important multicopper oxidases that are involved in many biotechnol. processes; however, they suffer from poor stability as well as high cost for production/purification Herein, we found that DNA-copper hybrid nanoflowers, prepared via simple self-assembly of DNA and copper ions, exhibit an intrinsic laccase-mimicking activity, which is significantly higher than that of control materials formed in the absence of DNA. Upon testing all four nucleobases, we found that hybrid nanoflowers composed of guanine-rich ssDNA and copper phosphate (GNFs) showed the highest catalytic activity, presumably due to the affirmative coordination between guanine and copper ions. At the same mass concentration, GNFs had similar Km but 3.5-fold higher Vmax compared with those of free laccase, and furthermore, they exhibited significantly-enhanced stability in ranges of pH, temperature, ionic strength, and incubation period of time. Based on these advantageous features, GNFs were applied to paper microfluidic devices for colorimetric detection of diverse phenolic compounds such as dopamine, catechol, and hydroquinone. In the presence of phenolic compounds, GNFs catalyzed their oxidation to react with 4-aminoantipyrine for producing a colored adduct, which was conveniently quantified from an image acquired using a conventional smartphone with ImageJ software. Besides, GNFs successfully catalyzed the decolorization of neutral red dye much faster than free laccase. This work will facilitate the development of nanoflower-type nanozymes for a wide range of applications in biosensors and bioremediation.

Biosensors & Bioelectronics published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C15H10O2, Formula: C18H24N6O6S4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Phoon, C. W. published the artcileBiological evaluation of hepatitis C virus helicase inhibitors, Category: thiazole, the publication is Bioorganic & Medicinal Chemistry Letters (2001), 11(13), 1647-1650, database is CAplus and MEDLINE.

A small chem. library has been synthesized and assayed for inhibition of HCV helicase activity. This study provides the structure-activity relationship of the reported inhibitors, with emphasis placed on the aminophenylbenzimidazole moiety and the linkers. Our data highlight the importance of preserving the aminophenylbenzimidazole core and the hydrophobic linkers for biol. activity. The development of a robust HCV helicase assay is also described.

Bioorganic & Medicinal Chemistry Letters published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Kulkarni, Santosh S. published the artcileDiscovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists, Synthetic Route of 791614-90-9, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(11), 2987-2991, database is CAplus and MEDLINE.

Investigation of a series of heterobicyclic compounds with essential pharmacophoric features of the metabotropic glutamate receptor 5 (mGluR5) antagonists MPEP and MTEP provided novel structural templates with sub-micromolar affinities at the mGluR5. Compound I showed antagonist activity (IC₅₀ = 0.26 μM) in the functional assay measuring hydrolysis of phosphoinositide and may provide a new lead for further SAR investigation.

Bioorganic & Medicinal Chemistry Letters published new progress about 791614-90-9. 791614-90-9 belongs to thiazole, auxiliary class Boronate Esters,Boronic acid and ester,Boronic acid and ester, name is 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole, and the molecular formula is C14H18BNO2S, Synthetic Route of 791614-90-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Tsemeugne, Joseph published the artcileSynthesis, characteristic fragmentation patterns and antibacterial activity of new azo compounds from the coupling reaction of diazobenzothiazole ions and acetaminophen, Recommanded Product: 6-Chlorobenzothiazol-2-ylamine, the publication is Heterocyclic Communications (2021), 27(1), 79-89, database is CAplus.

A series of azobenzothiazole dyes were synthesized via diazotization of substituted benzothiazole derivatives followed by azo coupling with acetaminophen. The chem. structures of all synthesized compounds were confirmed using anal. data and spectroscopic techniques, including UV-visible, IR, mass spectra and ¹H- and ¹³C-NMR. The in situ formed diazobenzothiazole ions regiospecifically reacted with acetaminophen derivatives in the Hollemann-guided electrophilic aromatic substitution mechanism. The regio-orientations were established, on the one hand, by a rigorous interpretation of ¹H-NMR spectra and, on the other hand, by the characteristic fragmentation patterns observed on the electrospray mass spectra. In the cases of I and II, multisubstitutions occurred. The antimicrobial activity of synthesized azobenzothiazole dyes, along with all the starting materials, was investigated on Pseudomonas aeruginosa PA01, Staphylococcus aureus 18, Escherichia coli 64R and S. aureus ATCC 25923. The results showed that this skeletal framework exhibited marked potency as antibacterial agents. The most active antibacterial agent against both targeted organisms was 1,2-bis(benzo[d]thiazol-2-yl)diazene trihydrate.

Heterocyclic Communications published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C8H7NO4, Recommanded Product: 6-Chlorobenzothiazol-2-ylamine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Katritzky, Alan R. published the artcileAqueous high-temperature chemistry of carbo- and heterocycles. 11. Aquathermolysis of arylamines in the presence and absence of sodium bisulfite, Name: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Energy & Fuels (1990), 4(5), 547-55, database is CAplus.

Thermolysis and neutral aqueous thermolysis of ring- and N-substituted anilines showed either no reaction or little conversion. In aqueous 10% H₃PO₄ the anilines underwent denitrogenation to give phenols. Friedel-Crafts alkylations and dealkylations were observed for alkyl-substituted anilines, together with the formation of diarylamines and carbazoles, both in runs with H₃PO₄ and in runs with an aqueous sulfite/bisulfite mixture Mechanistic pathways are suggested for the formation of all products. The foregoing has relevance to heteroatom elimination from coal, kerogen, and heavy oils.

Energy & Fuels published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Name: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Lartia, Remy published the artcileVersatile Introduction of Azido Moiety into Oligonucleotides through Diazo Transfer Reaction, HPLC of Formula: 1192027-04-5, the publication is Organic Letters (2011), 13(20), 5672-5675, database is CAplus and MEDLINE.

The use of a diazo transfer (DZT) reagent enables clean and efficient conversion of amino oligodeoxyribonucleotides (ODNs) into their azido counterparts under mild conditions. ODNs bearing an amino tether at the 3′, 5′, or any internal position could be modified in this manner thus demonstrating the versatility of this reaction. Easy access to such azido-modified ODNs is of great interest for conjugation in particular through click’ copper catalyzed 1,3-dipolar cycloaddition (CuAAC reaction).

Organic Letters published new progress about 1192027-04-5. 1192027-04-5 belongs to thiazole, auxiliary class Other Aliphatic Heterocyclic,Amine, name is N,N-Dimethyl-N’-(3-thioxo-3H-1,2,4-dithiazol-5-yl)formimidamide, and the molecular formula is C5H7N3S3, HPLC of Formula: 1192027-04-5.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Saha, Rituparna published the artcileElectrochemical analysis of Catechol polymerization in presence of Trametes versicolor laccase and the mediator ABTS, Safety of Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is Enzyme and Microbial Technology (2022), 109934, database is CAplus and MEDLINE.

The phenolic compound catechol has found various applications in the industry but is often discharged untreated in industrial effluents. Catechol is highly toxic and adversely affects the environment. This has increased extensive investigation into elucidating the effects of various synthetic elements or different biocatalysts on catechol, thereby leading the way to its bioremediation. Hence, an electrochem.-based study on catechol in the presence of the enzyme laccase could provide a basic understanding of the unique characteristics exhibited by catechol, thus facilitating a distinct perspective to its subsequent treatment and removal. The present study focuses on the electrochem. characterization of catechol based on the oxidation of laccase and the redox mediator 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). Catechol exhibited distinct electrochem. behavior across various concentrations The unique electroactive nature of ABTS assisted in the polymerization of catechol which was found to be concentration-dependent. Laccase produced a higher oxidation-reduction rate, thereby producing a much more stable condition for the polymerization of catechol. However, with the laccase-mediator system (LMS), the catechol polymerization rate was distinctly higher and more gradual with the enzyme utilizing the electroactive species produced by ABTS to increase the electron transfer and producing a combinatorial impact on the phenolic compound This study could rightly serve as the building block in developing future technologies like wastewater treatment and biosensors for catechol bioremediation.

Enzyme and Microbial Technology published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Safety of Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Hazra, Dipak K. published the artcileAb initio powder structure analysis and theoretical study of two thiazole derivatives, Related Products of thiazole, the publication is Journal of Molecular Structure (2013), 153-159, database is CAplus.

Crystal structures of 2-amino-5-methylthiazole (1) and 4-(6-methyl-2-benzothiazolyl) aniline (2) have been determined from laboratory X-ray powder diffraction data along with an anal. of the Hirshfeld surfaces and 2D-fingerprint plots, facilitating a comparison of intermol. interactions. The DFT optimized mol. geometries in (1) and (2) agree closely with those obtained from the crystallog. studies. An interplay of NH···N/S hydrogen bonds and C/NH···π interactions connects the mols. of (1) and (2) into two-dimensional framework. Hirshfeld surface anal. of (1) indicates that the H···H and H···π contacts can account for 56.9% of the Hirshfeld surface area, whereas the corresponding fraction in (2) is 80.5%.

Journal of Molecular Structure published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Ukrainets, I. V. published the artcile4-hydroxy-2-quinolones. 122. 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid hetarylamides as potential antitubercular agents, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2007), 43(7), 863-870, database is CAplus.

An improved method is reported for the synthesis of a series of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid hetarylamides, e.g., I. The antitubercular activity of all of the compounds prepared has been studied. The structure-biol. activity dependence revealed is discussed.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C40H35N7O8, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Lopez, Rosana published the artcileThe apparent dipole moments and molar volumes of 1,3-benzothiazole and some derivatives, in nonpolar solvents, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1999), 2225-2229, database is CAplus.

The apparent mol. polarizations at infinite dilution, P_2∞, mol. refractions, R_D, dipole moments, μ₂, polarizabilities, α, partial molar volumes, V ⁰_2,m, of 1,3-benzothiazole and some derivatives at position 2 or 3, were determined from relative permittivity, d. and refractive index measurements in n-hexane or 1,4-dioxane solutions at 25°. The R_D and V ⁰_2,m values correlate well for all substances studied, independently of the solvent used. The P_2∞ values appear to be slightly dependent on the solvent showing the presence of specific interactions as H bond. The apparent relative permittivity, ε₂‘, and the refraction index extrapolated at the IR region, n_IR, were estimated for all solutes. In the case of 1,3-benzothiazole and its 2-Me derivative, these results were compared with the relative permittivities measured at 25° at low and high frequencies, resp., by the Cole-Cole dynamic method, showing a good agreement. The apparent dipole moments and their changes with the corresponding substituent group were determined by 3 different methods. From the measurement of dipole moment it was unambiguously established that the tautomeric equilibrium between 2-mercapto-1,3-benzothiazole and 2-thioxo-3H-1,3-benzothiazole is strongly displaced to the latter. Changes in the apparent molar solution volumes and apparent molar polarizations of the solutes in the considered solvents are qual. discussed. Comparison between pK_a values reported in the literature and the corresponding μ values for free base benzothiazole derivatives were carried out as well as the appropriate qual. discussion.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica