Day: November 29, 2022

Bodireddy, Mohan Reddy published the artcileLactic acid-mediated tandem one-pot synthesis of 2-aminothiazole derivatives: a rapid, scalable, and sustainable process, Application of 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Cogent Chemistry (2016), 2(1), 1154237/1-1154237/13, database is CAplus.

Environmentally benign and biodegradable lactic acid was identified as alternative solvent and catalyst for the tandem one-pot synthesis of Hantzsch 2-aminothiazole derivatives from readily available aralkyl ketones through in-situ regioselective α-bromination using N-bromosuccinimide followed by heterocyclization using thiourea at 90-100°. The major advantages of the present method include short reaction times (10-15 min), practical, simple to perform, easy work-up, good yield of products (up to 96%), productive for large-scale applications, free from apply of α-bromoketones (lachrymator) as substrates, avoids column purification Hence, the present method met with the concepts of both Wender’s “ideal synthesis” and sustainable chem. process.

Cogent Chemistry published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Application of 4-(Naphthalen-1-yl)thiazol-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Kar, Soumya Ranjan published the artcileGreen synthesis, characterization and antibacterial activity studies of new multifunctional nano polymeric material, which may have multidimensional application in water purification, Category: thiazole, the publication is Polymer Bulletin (Heidelberg, Germany), database is CAplus.

A novel polymeric resin was synthesized by condensing a Schiff base of 6-chloro-2-aminobenzothiazole and salicyldehyde with formaldehyde, which may have multidimensional application. First step of the synthesis of novel polymeric material is synthesis of Schiff base, which is the monomer of the resin. The Schiff base was synthesize by using greener method to reduce hazardous chem. waste and reaction time, so that reduction of environmental pollution and conservation of energy can be achieved. The greener method is compared with the conventional method. The metal polychelates of the polymeric resin with Cu²⁺ and Fe³⁺ were synthesized. The Schiff base, resin and its polychelates were converted to nanodimension and its dimension is measured by DLS method. The structure of the Schiff base, resin and polychelates are ascertained by FTIR, ¹H NMR spectroscopy. The exptl. data are compared with the computational data obtained from Gaussian software to ascertain the synthesis of these materials. These materials have a very wide range of application starting from anal. chem. to biochem. The antibacterial activities of Schiff base, resin and metal polychelates were studied against pathogenic bacteria Escherichia coli by turbidity measurement method. All these materials are found to be effective against the tested bacterial species, whereas the polychelates are shown exceptional results.

Polymer Bulletin (Heidelberg, Germany) published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Rajitha, Kamalon published the artcileSynthesis of graphene oxide-based nanofillers and their influence on the anticorrosion performance of epoxy coating in saline medium, COA of Formula: C13H10N2S, the publication is Diamond and Related Materials (2020), 107974, database is CAplus.

The present study investigated the anticorrosion performance of epoxy coating by the incorporation of two different functionalized graphene oxides as nanofillers in saline media. GO was functionalized with 2-aminothiazole (AT) and 2-amino-4-(1-Naphthyl)Thiazole (ANT) and modified compounds were characterized by X-ray diffraction (XRD), Fourier transform IR spectroscopy (FT-IR), Thermogravimetric anal. (TGA), Raman spectroscopy, and SEM. 0.2 Weight% of neat epoxy and epoxy nanocomposites (GO-AT/EP and GO-ANT/EP) were coated on mild steel substrate by a spin coating method and the formation of a protective film on the steel surface was confirmed using SEM, Atomic Force Microscopy (AFM) and contact angle test. The electrochem. impedance spectroscopy was employed to study the corrosion protection properties of nanocomposite coatings in 3.5% NaCl medium. The results signify the better anticorrosion performance of nanocomposite coatings due to their two-dimensional sheet structures, uniform dispersion and exfoliation in the epoxy matrix, hydrophobic nature and stopping up tiny pores properties. The GO-ANT/EP coating exhibited higher coating resistance (6.598 x 107 Ω cm²) than GO-AT/EP (1.017 x 105 Ω cm²) and pure epoxy (1270 Ω cm²) coating. The crowded structure of GO-ANT helps in forming highly crosslinked compact epoxy coating and therefore displays excellent corrosion protection efficiency than other coatings.

Diamond and Related Materials published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, COA of Formula: C13H10N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Mohinuddin, Pinjari K. Md. published the artcileMontmorillonite K-10 Clay Mediated Green Synthesis of 2-Amino-4-aryl thiazole Derivatives from α-Brominated Aralkyl Ketones in Water, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Current Green Chemistry (2015), 2(2), 163-169, database is CAplus.

Montmorillonite K-10 clay has been identified as an efficient and green catalyst for the synthesis of 2-amino-4-aryl thiazole derivatives I (R = 4-H₃CC₆H₄, 1-naphthyl, 2-naphthyl, etc.; R¹ = H, CH₃) in good to excellent isolated yields (80-96%) from α-brominated aralkyl ketones RC(O)C(R¹)Br and thiourea in aqueous medium at 25-30 °C. The present procedure offers advantages of short reaction time, simple work-up, high yields of products and the catalyst is environmentally benign and exhibits remarkable reusable activity by four times.

Current Green Chemistry published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Ahdenov, Reza published the artcileEelectrosynthesis of benzothiazole derivatives via C-H thiolation, Computed Properties of 95-24-9, the publication is Heterocyclic Communications (2022), 28(1), 67-74, database is CAplus.

Benzothiazole derivatives are essential intermediates in synthesizing a wide variety of medical and pharmaceutical compounds, and there is a great demand for a simple and efficient method to synthesize benzothiazoles under mild reaction conditions. Organic electrosynthesis as an energy-efficient process represents an environmentally benign and safer method than traditional methods for organic synthesis. Herein, authors present bromine-free and straightforward synthesis of 2-amino benzothiazole derivatives via the reaction of aniline derivatives and ammonium thiocyanate using electrosynthesis in the presence of sodium bromide both as an electrolyte and as a brominating agent at room temperature in iso-Pr alc. (i-PrOH) as a solvent. The reaction of ammonium thiocyanate via C-H thiolation routes, using various aniline derivatives, resulted in a simple, green, and bromine-free synthesis of 2-amino benzothiazole in moderate to good yields under mild reaction conditions. Riluzole drug can be produced using the same procedure in moderate yields.

Heterocyclic Communications published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Computed Properties of 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Muri, Estela Maris F. published the artcileDesign and synthesis of heterocyclic hydroxamic acid derivatives as inhibitors of Helicobacter pylori urease, Recommanded Product: Methyl 2-(2-aminothiazol-4-yl)acetate, the publication is Synthetic Communications (2003), 33(12), 1977-1995, database is CAplus.

Helicobacter pylori produces ammonia to help counter the acidic environment in the human stomach. The production of ammonia, essential for the microorganism’s survival and virulence, is the product of enzymic conversion of urea by the H. pylori’s urease. Inhibition of urease activity by dipeptide hydroxamic acids has previously been demonstrated using a variety of fluorides, thiols and hydroxamic acids. Studies employing computer-aided drug design techniques have been utilized to suggest a novel series of heterocyclic hydroxamic acid derivatives as potential urease inhibitors. Heterocyclic compounds such as I, II, III, and IV have been designed, synthesized, and preliminarily tested as dipeptide mimics which offer a structure that is more biol. stable than that of the reported dipeptide inhibitors.

Synthetic Communications published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C6H8N2O2S, Recommanded Product: Methyl 2-(2-aminothiazol-4-yl)acetate.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Muri, E. M. F. published the artcileMolecular modeling, synthesis and biological evaluation of heterocyclic hydroxamic acids designed as Helicobacter pylori urease inhibitors, Computed Properties of 64987-16-2, the publication is Letters in Drug Design & Discovery (2004), 1(1), 30-34, database is CAplus.

A computer-generated homol. model of the antimicrobial target Helicobacter pylori urease was derived, using the x-ray crystal structure of Klebsiella aerogenes as a template, in order to design novel urease inhibitors. Based on these computational studies, several heterocyclic hydroxamic acid derivatives have been designed, synthesized, and examined for their ability to inhibit urease activity.

Letters in Drug Design & Discovery published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C6H8N2O2S, Computed Properties of 64987-16-2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Maurya, R. C. published the artcileMagneto, spectral and thermal studies of some mixed-ligand cyanonitrosyl chromium (CrNO)⁵ complexes involving benzothiazole derivatives, COA of Formula: C14H12N2S, the publication is Journal of the Institution of Chemists (India) (1992), 64(1), 7-8, database is CAplus.

[Cr(NO)(CN)₂L₂(H₂O)] (L = 2-amino-6-ethoxy-, 2-amino-4-chloro-, 2-amino-6-nitro-, 2-amino-5,6-dimethyl-, 2-(2-tolyl)-, 2-(4-aminophenyl)-6-methylbenzothiazoles) were prepared and characterized by elemental anal., magnetic, molar conductance, TGA, and IR and ESR spectral methods. The benzothiazoles act as monodentate ligands coordinating through tertiary N.

Journal of the Institution of Chemists (India) published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, COA of Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Tomasic, Tihomir published the artcileDesign, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors, Application of Methyl 2-(2-aminothiazol-4-yl)acetate, the publication is Bioorganic & Medicinal Chemistry (2017), 25(1), 338-349, database is CAplus and MEDLINE.

Two new series of Escherichia coli DNA gyrase inhibitors bearing the 4,5-dibromopyrrolamide moiety was designed and synthesized. 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazole-2,6-diamine derivatives inhibited E. coli DNA gyrase in the submicromolar to low micromolar range (IC₅₀ values between 0.891 and 10.4 μM). Their “ring-opened” analogs, based on the 2-(2-aminothiazol-4-yl)acetic acid scaffold, displayed weaker DNA gyrase inhibition with IC₅₀ values between 15.9 and 169 μM. Mol. docking experiments were conducted to study the binding modes of inhibitors.

Bioorganic & Medicinal Chemistry published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C13H15NO6S, Application of Methyl 2-(2-aminothiazol-4-yl)acetate.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Wu, Shixin published the artcileTestis transcriptome profiling identified genes involved in spermatogenic arrest of cattleyak, Product Details of C7H5ClN2S, the publication is PLoS One (2020), 15(2), e0229503, database is CAplus and MEDLINE.

Much attempt has been made to examine the mechanisms of male sterility caused by spermatogenic arrest, but yet there is no research systematically and precisely elucidated testis gene expression profiling between cattleyak and yak. Methods: To explore the higher resolution comparative transcriptome map between the testes of yak and cattleyak, and further analyze the mRNA expression dynamics of spermatogenic arrest in cattleyak. We characterized the comparative transcriptome profile from the testes of yak and cattleyak using high-throughput sequencing. Then we used quant. anal. to validate several differentially expressed genes (DEGs) in testicular tissue and spermatogenic cells. Results: Testis transcriptome profiling identified 6477 DEGs (2919 upregulated and 3558 downregulated) between cattleyak and yak. Further anal. revealed that the marker genes and apoptosis regulatory genes for undifferentiated spermatogonia were upregulated, while the genes for differentiation maintenance were downregulated in cattleyak. A majority of DEGs associated with mitotic checkpoint, and cell cycle progression were downregulated in cattleyak during spermatogonial mitosis. Furthermore, almost all DEGs related to synaptonemal complex assembly, and meiotic progression presented no sign of expression in cattleyak. Even worse, dozens of genes involved in acrosome formation, and flagellar development were dominantly downregulated in cattleyak.

PLoS One published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C30H42NOP, Product Details of C7H5ClN2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica