Prangkio, Panchika published the artcileSelf-assembled, cation-selective ion channels from an oligo(ethylene glycol) derivative of benzothiazole aniline, Name: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Biochimica et Biophysica Acta, Biomembranes (2011), 1808(12), 2877-2885, database is CAplus and MEDLINE.
This paper describes the spontaneous formation of well-defined pores in planar lipid bilayers from the self-assembly of a small synthetic mol. that contains a benzothiazole aniline (BTA) group attached to a tetra-ethylene glycol (EG4) moiety. Macroscopic and single-channel current recordings suggest that these pores are formed by the assembly of four BTA-EG4 monomers with an open pore diameter that appears similar to the one of gramicidin pores (∼0.4 nm). The single-channel conductance of these pores is modulated by the pH of the electrolyte and has a min. at pH ∼3. Self-assembled pores from BTA-EG4 are selective for monovalent cations and have long open channel lifetimes on the order of seconds. BTA-EG4 monomers in these pores appear to be arranged sym. across both leaflets of the bilayer, and spectroscopy studies suggest that the fluorescent BTA group is localized inside the lipid bilayers. In terms of biol. activity, BTA-EG4 mols. inhibited growth of gram-pos. Bacillus subtilis bacteria (IC50 ∼50 μM) and human neuroblastoma SH-SY5Y cells (IC50 ∼60 μM), while they were not toxic to gram-neg. Escherichia coli bacteria at a concentration up to 500 μM. Based on these properties, this drug-like, synthetic, pore-forming mol. with a mol. weight below 500 g mol-1 might be appealing as a starting material for development of antibiotics or membrane-permeating moieties for drug delivery. From a biophys. point of view, long-lived, well-defined ion-selective pores from BTA-EG4 mols. offer an example of a self-assembled synthetic supramol. with biol. function.
Biochimica et Biophysica Acta, Biomembranes published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Name: 2-(4-Aminophenyl)-6-methylbenzothiazole.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica