Tsemeugne, Joseph published the artcileSynthesis, characteristic fragmentation patterns and antibacterial activity of new azo compounds from the coupling reaction of diazobenzothiazole ions and acetaminophen, Recommanded Product: 6-Chlorobenzothiazol-2-ylamine, the publication is Heterocyclic Communications (2021), 27(1), 79-89, database is CAplus.
A series of azobenzothiazole dyes were synthesized via diazotization of substituted benzothiazole derivatives followed by azo coupling with acetaminophen. The chem. structures of all synthesized compounds were confirmed using anal. data and spectroscopic techniques, including UV-visible, IR, mass spectra and 1H- and 13C-NMR. The in situ formed diazobenzothiazole ions regiospecifically reacted with acetaminophen derivatives in the Hollemann-guided electrophilic aromatic substitution mechanism. The regio-orientations were established, on the one hand, by a rigorous interpretation of 1H-NMR spectra and, on the other hand, by the characteristic fragmentation patterns observed on the electrospray mass spectra. In the cases of I and II, multisubstitutions occurred. The antimicrobial activity of synthesized azobenzothiazole dyes, along with all the starting materials, was investigated on Pseudomonas aeruginosa PA01, Staphylococcus aureus 18, Escherichia coli 64R and S. aureus ATCC 25923. The results showed that this skeletal framework exhibited marked potency as antibacterial agents. The most active antibacterial agent against both targeted organisms was 1,2-bis(benzo[d]thiazol-2-yl)diazene trihydrate.
Heterocyclic Communications published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C8H7NO4, Recommanded Product: 6-Chlorobenzothiazol-2-ylamine.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica