Vernin, Gaston published the artcileThin-layer and gas chromatography of thiazole and benzothiazole heterocycles, Synthetic Route of 5053-24-7, the publication is Bulletin de la Societe Chimique de France (1967), 846-56, database is CAplus.
Compounds of the general formula I, II, and III were prepared according to known methods and the effect of different factors on their mobility was studied. The following were prepared (I, R, R1, R2, and b.p. given): H, H, H, 117-18°; Me, H, H, 128-30°; Et, H, H, 148°; H, Me, Me, 133°; H, Et, H, 145°; H, iso-Pr, H, 171°; H, H, Me, 141°; H, H, Et, 162°; Me, Me, H, 145°; Me, H, Me, 149°; H, Me, Me, 158°; iso-Pr, H, H, 160°; Pr, H, H, 175°; iso-Bu, H, H, 172°; tert-Bu, H, H, 180°; neopentyl, H, H, 198°; Cl, H, H, 142°; Br, H, H, b20 69-71°; iso-Pr, Me, H, b50 92°; tert-Bu, Me, H, b50 96°; Me, tert-Bu, H, b50 96°; Et, tert-Bu, H, b50 108°; iso-Pr, tert-Bu, H, b50 113°; tert-Bu, tert-Bu, H, b50 114°; MeS, H, H, -; EtS, H, H, -; PrS, H, H, -; iso-PrS, H, H, -; tert-BuS, H, H, -; iso-Bu, H, H, -; PhCH2S, H, H, -; SH, H, H, -; SH, Me, H, -; SH, H, Me, -; MeS, H, H, -, SH, Me, Me, -; MeS, Me, H, -; MeS, Me, Me, -; SH, Ph, H, -; (II, R, R1, and R2 given): H, H, H; H, Me, H; H, H, Me; Me, H, H; H, Me, Me; Me, Me, H; Me, Me, Me; H, Ph, H; and (III, R and b.p. given): H, 231°; Me, 240°; Et, 252°; Pr, 256°; iso-Pr, 261°; iso-Bu, 269°; tert-Bu, b16 138°; neopentyl, -, m. 52°. Thin-layer chromatog. gives a better separation than gas phase chromatog. for the 2-Me, 2-Ph, 4-Me, 4-Ph, and 2,4-di-Me compounds The mobility of methylthiazoles decreases in the following manner: 4-Me > 5-Me > 2-Me; polar effects are similar for the groups: Et, iso-Pr, and tert-Bu. Steric effects become important for the groups iso-Pr and tert-Bu.
Bulletin de la Societe Chimique de France published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C15H14Cl2S2, Synthetic Route of 5053-24-7.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica