Vincent, Emile J. published the artcilePhysicochemical studies of the thiazole ring. I. Chemical shifts and N.M.R. coupling constants, Computed Properties of 5053-24-7, the publication is Bulletin de la Societe Chimique de France (1966), 3524-30, database is CAplus.
N.M.R. spectra of thiazole (I) and 42 derivatives containing alkyl, halo, amino, and other groups were investigated. Chem. shifts and coupling constants for the 2-, 4-, and 5-protons were determined at a uniform 5% concentration in CCl4, and also in a series of 15 solvents at infinite dilution Spectra were also measured with 2-thiazoline, 5,5-dimethyl-3-thiazoline, and 2,2,4-trimethyl-3-thiazoline for comparison. The observed chem. shifts in substituted thiazoles indicated the existence of an aromatic ring current, and were consistent with the view that the amount of shielding at any position of the ring is a function of π-electron d., rather than of inductive effects transmitted through σ-bonds. The chem. shifts and coupling constants of all 3 thiazoles ring protons were found to be quite solvent-dependent, although the 4-proton was somewhat less sensitive to solvent change. From the spectra of I and its 2-, 4-, and 5-Me derivatives in C6H6 it was concluded that the π-electrons of C6H6 interact preferentially with the relatively pos. 1- and 2-positions of the thiazole ring. Association between I and Me2NCHO was likewise demonstrable. The plane of Me2NCHO was assumed to be perpendicular to that of I, the formyl portion of Me2NCHO being located preferentially above the 5 position of I.
Bulletin de la Societe Chimique de France published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C24H12, Computed Properties of 5053-24-7.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica