Month: November 2022

Joshi, Medha published the artcilePoly (urethane-urea)-epoxy glass fiber reinforced composites, Quality Control of 95-24-9, the publication is International Journal of ChemTech Research (2021), 14(1), 199-205, database is CAplus.

A series of poly(urethane-urea)s (PUU)s were synthesized using toluene 2, 4- diisocyanate, various 2-amino benzothiazoles and 3-amino phenol. All the PUUs were characterized by elemental anal., spectral studies, number average mol. weight (Mn) and thermogravimetry. Further reaction of PUUs was carried out with an epoxy resin (i.e.DGEBA). The curing study of prepared resins was monitored by DSC. Based on DSC thermograms glass fiber reinforced composites have been laminated and characterized by chem., mech. and elec. properties. The unreinforced cured resins were subjected to thermogravimetric anal.

International Journal of ChemTech Research published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Quality Control of 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Liu, Jingbao published the artcileDesign, synthesis, and biological evaluation of 2-substituted ethenesulfonic acid ester derivatives as selective PTP1B inhibitors, Name: 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Pharmazie (2015), 70(7), 446-451, database is CAplus and MEDLINE.

Fifteen 2-substituted ethenesulfonic acid ester derivatives were designed, synthesized, and evaluated for the inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) and T-Cell protein tyrosine phosphatase (TCPTP). The structural activity relationship (SAR) of these compounds were discussed to clarify the impact of the linker and the optimized tail on the inhibitory activity of PTP1B and selectivity over TCPTP. Most of the compounds exhibited excellent inhibitory activities against PTP1B with IC₅₀ values of 1.5-8.9 μM. SAR anal. revealed that the substituents at the hydrophobic tail significantly alter the inhibitory activity against PTP1B and selectivity over TCPTP, e.g. compound Ethyl-2-(4-(3-(4-(2-chlorophenyl)thiazol-2-ylamino)propoxy)phenyl)ethenesulfonate showed excellent inhibitory activity to PTP1B with IC₅₀ = 7.8 μM, and ∼6-fold selectivity over TCPTP. Combined with our previous findings, that the linker length and the substituted hydrophobic tail had decisive influence on the PTP1B inhibitory activity and selectivity was confirmed.

Pharmazie published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Name: 4-(Naphthalen-1-yl)thiazol-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Oegretir, Cemil published the artcileDetermination and Evaluation of Acid Dissociation Constants of Some Substituted 2-Aminobenzothiazole Derivatives, Safety of 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Journal of Chemical & Engineering Data (2008), 53(2), 422-426, database is CAplus.

The acid dissociation constants of some 4- and/or 6-substituted 2-aminobenzothiazole and 4-substituted thiazole derivatives were determined spectroscopically. With the exception of a few, the first protonation was found to occur on the amino group. In some mols. where prototropic tautomerism is possible, a change-over in the protonation mechanism was observed The first protonation under these circumstances was found to occur on the imino nitrogen atom. The second protonation takes place on the thiazole ring nitrogen atom.

Journal of Chemical & Engineering Data published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Safety of 4-(Naphthalen-1-yl)thiazol-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Hanke, Thomas published the artcileAminothiazole-Featured Pirinixic Acid Derivatives As Dual 5-Lipoxygenase and Microsomal Prostaglandin E₂ Synthase-1 Inhibitors with Improved Potency and Efficiency in Vivo, Related Products of thiazole, the publication is Journal of Medicinal Chemistry (2013), 56(22), 9031-9044, database is CAplus and MEDLINE.

Dual inhibition of microsomal prostaglandin E₂ synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) is currently pursued as potential pharmacol. strategy for treatment of inflammation and cancer. Here we present a series of 26 novel 2-aminothiazole-featured pirinixic acid derivatives as dual 5-LO/mPGES-1 inhibitors with improved potency (exemplified by compound 2-[(4-chloro-6-{[4-(naphthalen-2-yl)-1,3-thiazol-2-yl]-amino}-pyrimidin-2-yl)-sulfanyl]-octanoic acid (I) with IC₅₀ = 0.3 and 0.4 μM, resp.) and bioactivity in vivo. Computational anal. presumes binding sites of I at the tip of the 5-LO catalytic domain and within a subpocket of the mPGES-1 active site. Compound I (10 μM) hardly suppressed cyclooxygenase (COX)-1/2 activities, failed to inhibit 12/15-LOs, and is devoid of radical scavenger properties. Finally, compound I reduced vascular permeability and inflammatory cell infiltration in a zymosan-induced mouse peritonitis model accompanied by impaired levels of cysteinyl-leukotrienes and prostaglandin E₂. Together, 2-aminothiazole-featured pirinixic acids represent potent dual 5-LO/mPGES-1 inhibitors with an attractive pharmacol. profile as anti-inflammatory drugs.

Journal of Medicinal Chemistry published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Brandsma, L. published the artcileAn efficient synthesis of 1,3-thiazole, Recommanded Product: 2-(Methylthio)thiazole, the publication is Synthesis (1985), 948-9, database is CAplus.

The cyclocondensation of Me dithiocarbamate with ClCH₂CHO in aqueous ethanol afforded thiazole I (R = SMe). I (R = SMe) was demethylsulfenylated to I (R = H) by reaction with lithium in liquid ammonia followed by hydrolysis with aqueous ammonium chloride.

Synthesis published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Recommanded Product: 2-(Methylthio)thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Pandey, Deepshikha published the artcileBioremoval of toxic malachite green from water through simultaneous decolorization and degradation using laccase immobilized biochar, Application of Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is Chemosphere (2022), 134126, database is CAplus and MEDLINE.

In this study, decolorization and degradation of malachite green dye was studied using the laccase immobilized pine needle biochar. Successful immobilization of biochar was achieved by adsorption and confirmed through SEM and energy dispersive X-ray anal. (SEM-EDX), Fourier transform IR spectroscopy (FTIR). High laccase binding of 64.4 U/g and high immobilization yield of 78.1% was achieved using 4U of enzyme at pH3 and temperature 30 °C. The immobilized laccase retained >50% relative activity in the pH range 2-7, >45% relative activity at 65 °C and >55% relative activity at 4 °C for 4 wk. The re-usability of immobilized enzyme was checked with 2, 2′-azino-bis 3-ethylbenzothiazoline-6-sulfonic acid (ABTS) substrate and enzyme retained 53% of its activity after 6 cycles. Immobilized laccase was used for the degradation and decolorization of azo dye malachite green in aqueous solution More than 85% removal of malachite green dye (50 mg/L) was observed within 5 h. FTIR and high performance liquid chromatog. (HPLC) anal. clearly indicated the breakdown of dye and presence of metabolites (leuco malachite green, methanone, [4-(di-Me amino)pheny]phenyl and 3-dimethyl-Ph amine) in gas chromatog.-mass spectrometry (GC-MS) anal. confirmed the dye degradation Phytotoxicity anal. indicated that the enzymic degradation resulted in lesser toxic metabolites than the original dye. Thus, laccase immobilized biochar can be used as an efficient biocatalytic agent to remove dye from water.

Chemosphere published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Application of Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Nath, J. P. published the artcileSynthesis of some 7-substituted 8-hydroxyquinoline derivatives of thiazoles and oxazoles as potential pesticides, Quality Control of 56503-96-9, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1981), 20B(7), 606-7, database is CAplus.

Mannich reaction of 8-hydroxyquinoline with PhCHO and I (R = H, Cl, Br; R¹ = Ph, 4-ClC₆H₄, 4-BrC₆H₄, 4-HOC₆H₄, 4-MeO(C₆H₄, 3-O₂NC₆H₄, 4-O₂NC₆H₄, 4-MeC₆H₄, α-,β-naphthyl; X = O, S) gave the title compounds (II). II showed bactericidal and fungicidal activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Quality Control of 56503-96-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Chehab, Rana published the artcileDevelopment of an automated system for the analysis of inorganic chloramines in swimming pools via multi-syringe chromatography and photometric detection with ABTS, Quality Control of 30931-67-0, the publication is Talanta (2020), 120322, database is CAplus and MEDLINE.

Inorganic chloramines are disinfection byproducts resulting from the unwanted reaction between chlorine used as disinfectant in swimming pools and nitrogenous compounds brought by bathers. This parameter (total chloramines or combined chlorine) is currently measured on site by a colorimetric method that does not allow to measure only inorganic chloramines. In this paper, a multi-syringe chromatog. system combined with a post column derivatization is applied for the first time for the specific detection of the three individual inorganic chloramines (monochloramine, dichloramine and trichloramine). These latter ones are separated using a low-pressure monolithic C18 column, and sep. detected after a post-column reaction with the chromogenic reagent ABTS (2,2′-azino-bis-(3-ethyl-benzothiazoline)-6-sulfonic acid-diammonium salt). Development of two ABTS reagents provides discrimination of chlorine and monochloramine that are not separated on the column. Optimization of the exptl. conditions enables determination of inorganic chloramines with very good detection limits (around 10 μg eq.Cl₂ L^-1) without interferences from other chlorinated compounds such as organic chloramines or free available chlorine. The validation of the whole procedure has been successfully applied to real swimming pools samples.

Talanta published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Quality Control of 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Chau, Chi-Fai published the artcileCommercialized Sesame Oil Analysis: Quality Characterization and Oxidative Stability of Blended Sesame Oil, Quality Control of 30931-67-0, the publication is ACS Food Science & Technology (2021), 1(7), 1222-1227, database is CAplus.

Sesame oil is a high quality edible oil in Asia with unique flavor and aroma. However, sesame oil is more expensive than soybean oil; therefore, both sesame and soybean oil are blended to reduce costs. In this study, we performed quality characterization anal. of sesame oil (SeO) and sesame oil blended with soybean oil (B-SeO). In our results, fatty acid composition was not significantly different; however, acid, anisidine, peroxide, and total oxidation values of B-SeO were lower than SeO; B-SeO was found to meet CODEX quality standards for cold-pressed oil; 1,1-diphenyl-2-trinitrophenylhydrazine, 2,2-diazo-bis(3-ethyl-benzothiazole-6-sulfonic acid) diammonium salt scavenging capacity, and ferric reducing antioxidant power values of the SeO and B-SeO were in the following ranges 23.72-42.66%, 26.4-29.62%, and 0.44-0.57%, resp.; by following the Arrhenius equation, activation energies for oxidative stability of the two products ranged between 95.51 and 120.34 kJ/mol; antioxidant activities of these oil products were correlated with Maillard reaction products. In conclusion, it was determined that blending sesame oil with soybean oil improved the quality characterization and increased the applications and uses of sesame oil products.

ACS Food Science & Technology published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Quality Control of 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Kim, Mi Kyoung published the artcile3D-QSAR of PET agents for imaging β-amyloid in Alzheimer’s disease, Category: thiazole, the publication is Bulletin of the Korean Chemical Society (2007), 28(7), 1231-1234, database is CAplus.

The accumulation of excess senile plaques (β-amyloid, Aβ-plaques) in the brain is strongly associated with the pathogenesis of Alzheimer’s disease (AD). While there are no definitive treatments available to affect a cure of AD, much recent interest has been given to the development of antiamyloid therapies aimed at halting and reversing Aβ-deposition and, thus, monitoring of the therapeutic efficacy would greatly benefit from methods for the in vivo detection and quantification of Aβ-deposits in the brain. A 3D-QSAR model was constructed with several PET ligands such as Thioflavin-T analogs and stilbene derivatives using CoMFA (Comparative Mol. Field Anal.) and CoMSIA (Comparative Mol. Similarity Indexes Anal.). The 3D-QSAR model could be applied to predict binding affinity of the structurally related compounds against Aβ-plaques.

Bulletin of the Korean Chemical Society published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica