Month: November 2022

Verkruijsse, H. D. published the artcileCarbophilic versus thiophilic attack in the reaction of metalated aromates and heteroaromates with carbon disulfide, Related Products of thiazole, the publication is Journal of Organometallic Chemistry (1987), 332(1-2), 95-8, database is CAplus.

CuBr catalyzed the formation of RCSSLi (R = Ph, 2-MeOC₆H₄, 2-FC₆H₄, 4-FC₆H₄, 2-thienyl, 3-thienyl, 2-furyl, N-methylpyrryl, N-methylimidazolyl, 2-thiazolyl, 2-methylthio-2-thiazolyl) in the reaction of aryl- or heteroaryllithium reagents with CS₂. Subsequent addition of MeI gave RCSSMe in 64-90% yields. Appreciable amounts of RSMe and tars were obtained when the reaction with CS₂ was carried out in the absence of CuBr especially in the case of more basic organoalkali compounds

Journal of Organometallic Chemistry published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C9H22OSi, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Borthakur, Priyakshree published the artcileCuS nanoparticles decorated MoS₂ sheets as an efficient nanozyme for selective detection and photocatalytic degradation of hydroquinone in water, Recommanded Product: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is New Journal of Chemistry (2021), 45(19), 8714-8727, database is CAplus.

The development of cost effective and efficient nanomaterials with enzyme mimetics and photocatalytic activity has achieved tremendous research interest in the quant. detection as well as removal of toxic environmental pollutants. CuS nanoparticles decorated MoS2 sheets were successfully synthesized adopting a simple hydrothermal technique and using low-cost materials. The nanocomposite was successfully used as an efficient catalyst for the selective detection and removal of a toxic phenolic compound like hydroquinone (HQ). The CuS-MoS2 nanocomposite catalyzed the oxidation of different chromogenic substrates like 3,3′,5,5′-tetramethylbenzidine, 2,2′-azino-bis(3-ethylbenzo-thiazoline-6-sulfonic acid)diammonium salt, and o-phenylenediamine in the presence of H2O2, indicating its peroxidase-like activity as natural Horseradish peroxidase (HRP). The catalytic performance of the nanozyme was further investigated through the typical Michaelis-Menten kinetics. The results showed that the proposed sensor exhibited improved catalytic properties with a wide linear relationship (0.4-50μM) and a low detection limit of 3.68μM for HQ detection in aqueous medium. Meanwhile, the mechanism of HQ sensing in the presence of CuS-MoS2 nanozyme was systematically investigated. Moreover, the CuS-MoS2 nanozyme possessed significant photocatalytic activity and 83% HQ decomposition was achieved within 240 min under irradiation of natural sunlight. The mechanism of enhanced photocatalytic degradation of HQ through the formation of OH radicals as reactive species was evidenced by analyzing the formation of fluorescent active mols. on the addition of terephthalic acid and by high-resolution mass spectrometry. Thus CuS-MoS2 represents a new and promising HQ sensing material in a highly sensitive and fast manner as well as an efficient photocatalyst for the degradation of HQ to its non-toxic products under natural sunlight irradiation

New Journal of Chemistry published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Recommanded Product: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Bhoi, Manoj N. published the artcileNovel benzothiazole containing 4H-pyrimido[2,1-b]benzothiazoles derivatives: One-pot, solvent-free microwave assisted synthesis and their biological evaluation, HPLC of Formula: 95-24-9, the publication is Arabian Journal of Chemistry (2019), 12(8), 3799-3813, database is CAplus.

A series of pyrimido[2,1-b]benzothiazoles I [R = H, 6-Me, 8-Br, etc.] was synthesized via microwave-assisted one-pot three-component reaction of 2-aminobenzothiazoles with pyridine-2-aldehyde and Et acetoacetate in the presence of PdCl₂ as an expeditious catalyst under solvent-free conditions. The salient features of this approach were operational simplicity, convergence, short reaction time, high atom economy, easy workup, mild reaction conditions and environmentally benign conditions. All the newly synthesized pyrimido[2,1-b]benzothiazole derivatives were evaluated for their antibacterial, antitubercular and antioxidant activities. Among the tested compounds, pyrimido[2,1-b]benzothiazoles I [R = 6-Me, 8-Me, 6-Cl, 8-Cl, 8-NO₂] were found to be more active against tested Gram +ve and Gram -ve bacterial strains. Pyrimido[2,1-b]benzothiazoles I [R = 8-Me, 8-NO₂] showed very good % inhibition 72.9% and 70.32% resp. against Mycobacterium tuberculosis H₃₇RV whereas remaining compounds displayed moderate to good antitubercular activity. All the pyrimido[2,1-b]benzothiazoles I showed moderate to good antioxidant activity.

Arabian Journal of Chemistry published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, HPLC of Formula: 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

White, Lisa J. published the artcileControllable hydrogen bonded self-association for the formation of multifunctional antimicrobial materials, HPLC of Formula: 92-36-4, the publication is Journal of Materials Chemistry B: Materials for Biology and Medicine (2020), 8(21), 4694-4700, database is CAplus and MEDLINE.

SSAs are a class of supramol. self-associating amphiphilic salt, the anionic component of which contains a covalently bound hydrogen bond donor-acceptor motif. This results in a monomeric unit which can adopt multiple hydrogen bonding modes simultaneously. Previous investigations have shown examples of SSAs to act as antimicrobial agents against clin. relevant methicillin-resistant Staphylococcus aureus (MRSA). Herein, we report an intrinsically fluorescent SSA which can self-associate producing dimers, spherical aggregates and hydrogels dependent on solvent environment, while retaining antimicrobial activity against both model Gram-pos. (MRSA) and Gram-neg. (Escherichia coli) bacteria. Finally, we demonstrate the SSA supramol. hydrogel to tolerate the inclusion of the antibiotic ampicillin, leading to the enhanced inhibition of growth with both model bacteria, and derive initial mol. structure-physicochem. property-antimicrobial activity relationships.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C10H10CoF6P, HPLC of Formula: 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

White, Lisa J. published the artcileTowards the application of supramolecular self-associating amphiphiles as next-generation delivery vehicles, Product Details of C14H12N2S, the publication is Molecules (2020), 25(18), 4126, database is CAplus and MEDLINE.

Herein, we present a series of supramol. self-associating amphiphilic (SSA) salts and establish the potential for these mol. constructs to act as next-generation solution-state mol. delivery vehicles. We characterize the self-association of these SSAs, both alone and when co-formulated with a variety of drug(like) competitive guest species. Single crystal X-ray diffraction studies enable the observation of hydrogen-bonded self-association events in the solid state, while high resolution mass spectrometry confirms the presence of anionic SSA dimers in the gas-phase. These same anionic SSA dimeric species are also identified within a competitive organic solvent environment (DMSO-d6/0.5% H2O). However, extended self-associated aggregates are observed to form under aqueous conditions (H2O/5.0% EtOH) in both the absence and presence of these competitive guest species. Finally, through the completion of these studies, we present a framework to support others in the characterization of such systems.

Molecules published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C4H3Cl2N3, Product Details of C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

B, Manjunatha published the artcileCoumarin-Benzothiazole Based Azo Dyes: Synthesis, Characterization, Computational, Photophysical and Biological Studies, HPLC of Formula: 95-24-9, the publication is Journal of Molecular Structure (2021), 131170, database is CAplus.

In this paper, we have reported the synthesis of some coumarin-benzothiazole based azo dyes (C₁-C₅). The structure of the synthesized dyes was precisely established from their IR, NMR and HRMS spectra. The synthesized dyes were photophys. characterized by UV-Vis and Photoluminescence studies. Through the computational study, the optimized mol. geometry, and reactive parameters were investigated to get a better insight into the mol. properties. Mol. electrostatic potential (MEP) and Reduced d. gradient (RDG) were also studied for all the compounds Diffuse reflectance study was carried out to determine the energy gap (Eg) of the synthesized dyes. Addnl., the synthesized compounds were screened for their pharmacol. property against Mycobacterium tuberculosis (H37 RV strain). The in silico mol. docking study was also performed with enoyl-ACP reductase.

Journal of Molecular Structure published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, HPLC of Formula: 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Axton, Christopher A. published the artcileNovel immunosuppressive butenamides, Category: thiazole, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1992), 2203-13, database is CAplus.

2-[4-(1,1-Dimethylethyl)phenyl]thiophene was carboxylated using butyllithium and carbon dioxide to give 5-[4-(1,1-dimethylethyl)phenyl]thiophene-2-carboxylic acid. Conversion of the acid using di-Ph phosphazidate and triethylamine gave 5-[4-(1,1-dimethylethyl)phenyl]thiophene-2-carbonyl azide, which was rearranged in toluene at 110° with loss of nitrogen to give the isocyanate; this in turn was treated with sodium 1-cyanoprop-1-ene 2-oxide in THF to give 2-cyano-N-{5-[4-(1,1-dimethylethyl)phenyl]thiophen-2-yl}-3-hydroxybut-2-enamide (I). Analogous chem. has been utilized to synthesize both heteroarylphenylbutenamides, e.g., II and III and phenylbutenamides, e.g., IV ( R= Cl, Bu, Me₂CH, Me₃C, EtMe₂C, PrMe₂C), which display immunosuppressive activity towards proliferating Con A-stimulated T-lymphocytes.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Boutard, Nicolas published the artcileDiscovery and structure-activity relationships of N-aryl 6-aminoquinoxalines as potent PFKFB3 kinase inhibitors, COA of Formula: C14H18BNO2S, the publication is ChemMedChem (2019), 14(1), 169-181, database is CAplus and MEDLINE.

Energy and biomass production in cancer cells are largely supported by aerobic glycolysis in what is called the Warburg effect. The process is regulated by key enzymes, among which phosphofructokinase PFK-2 plays a significant role by producing fructose-2,6-biphosphate; the most potent activator of the glycolysis rate-limiting step performed by phosphofructokinase PFK-1. Herein, the synthesis, biol. evaluation and structure-activity relationship of novel inhibitors of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), which is the ubiquitous and hypoxia-induced isoform of PFK-2, are reported. X-ray crystallog. and docking were instrumental in the design and optimization of a series of N-aryl 6-aminoquinoxalines. The most potent representative, N-(4-methanesulfonylpyridin-3-yl)-8-(3-methyl-1-benzothiophen-5-yl)quinoxalin-6-amine, displayed an IC₅₀ of 14 nM for the target and an IC₅₀ of 0.49 μM for fructose-2,6-biphosphate production in human colon carcinoma HCT116 cells. This work provides a new entry in the field of PFKFB3 inhibitors with potential for development in oncol.

ChemMedChem published new progress about 791614-90-9. 791614-90-9 belongs to thiazole, auxiliary class Boronate Esters,Boronic acid and ester,Boronic acid and ester, name is 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole, and the molecular formula is C14H18BNO2S, COA of Formula: C14H18BNO2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Lei, Ying-jie published the artcileSynthesis of 2-(4-aminophenyl)-6-benzothiazoles derivatives in the presence of manganese(III) acetate, COA of Formula: C14H12N2S, the publication is Huaxue Yanjiu Yu Yingyong (2012), 24(10), 1596-1599, database is CAplus.

Several 4-nitrophenybenzothiazole intermediates were prepared by condensation reaction of 2-aminothiophenol and(substituted) 4-nitrobenzaldehyde in the presence of manganese(III) acetate and the procedure was shown to be mild and easy, which was followed with a reduction under the Pd/C catalyst to afford the desired amino derivatives and resulted in yields of 63-79%. The formation of the corresponding products was confirmed by IR, ¹HNMR and elemental anal.

Huaxue Yanjiu Yu Yingyong published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, COA of Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Jana, Asim published the artcileI₂/DMSO mediated multicomponent reaction for the synthesis of 2-arylbenzo[d]imidazo[2,1-b]thiazole derivatives, HPLC of Formula: 95-24-9, the publication is Organic & Biomolecular Chemistry (2019), 17(21), 5316-5330, database is CAplus and MEDLINE.

Synthesis of a series of 2-arylbenzo[d]imidazo[2,1-b]thiazoles tethered with barbituric acid moiety was reported from the three component reaction of 2-aminobenzothiazoles, barbituric acids and terminal aryl acetylenes or aryl Me ketones in the presence of I₂ in DMSO medium. Both conventional and microwave heating conditions was used for this multicomponent reaction. The salient features of this methodol. are: (i) formation of one C-C and two C-N bonds in one-pot under metal-free oxidation followed by cyclization (ii) selective formation of the fused imidazole ring, (iii) wide substrate scope (iv) easy purification of the products (v) products having more than one pharmaceutically important motifs and (vi) gram scale synthesis possible.

Organic & Biomolecular Chemistry published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, HPLC of Formula: 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica