Month: November 2022

Boles, Jessica E.; Bennett, Charlotte; Baker, Jennifer; Hilton, Kira L. F.; Kotak, Hiral A.; Clark, Ewan R.; Long, Yifan; White, Lisa J.; Lai, Hin Yuk; Hind, Charlotte K.; Sutton, J. Mark; Garrett, Michelle D.; Cheasty, Anne; Ortega-Roldan, Jose L.; Charles, Mark; Haynes, Cally J. E.; Hiscock, Jennifer R. published an article in 2022, the title of the article was Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of ′druggable′ supramolecular self-associating antimicrobial amphiphiles.Synthetic Route of 92-36-4 And the article contains the following content:

The rise of antimicrobial resistance remains one of the greatest global health threats facing humanity. Furthermore, the development of novel antibiotics has all but ground to a halt due to a collision of intersectional pressures. Herein we determine the antimicrobial efficacy for 14 structurally related supramol. self-associating amphiphiles against clin. relevant Gram-pos. methicillin resistant Staphylococcus aureus and Gram-neg. Escherichia coli. We establish the ability of these agents to selectively target phospholipid membranes of differing compositions, through a combination of computational host:guest complex formation simulations, synthetic vesicle lysis, adhesion and membrane fluidity experiments, alongside our novel 1H NMR CPMG nanodisc coordination assays, to verify a potential mode of action for this class of compounds and enable the production of evermore effective next-generation antimicrobial agents. Finally, we select a 7-compound subset, showing two lead compounds to exhibit ′druggable′ profiles through completion of a variety of in vivo and in vitro DMPK studies. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Synthetic Route of 92-36-4

The Article related to phospholipid druggable supramol self associating amphiphile antimicrobial, Placeholder for records without volume info and other aspects.Synthetic Route of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Stevanovic, Nevena; Jevtovic, Mima; Mitic, Dragana; Matic, Ivana Z.; Crnogorac, Marija Dordjic; Vujcic, Miroslava; Sladic, Dusan; Cobeljic, Bozidar; Andjelkovic, Katarina published an article in 2022, the title of the article was Evaluation of antitumor potential of Cu(II) complex with hydrazone of 2-acetylthiazole and Girard′s T reagent.Formula: C5H5NOS And the article contains the following content:

In this paper, the previously synthesized Cu(II) complex ([CuL1(N3) (CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, has been characterized and its biol. activity has been studied in detail. The Cu(II) complex consists of ligand coordinated in a deprotonated, formally neutral zwitter-ionic form, via NNO atoms, one azido ligand and one methanol mol. The Cu(II) complex was selected due to results of the cytotoxic activity, the brine shrimp test and DPPH radical scavenging activity, which were previously performed. The effects of Cu(II) complex on cell cycle phase distribution of cervical adenocarcinoma HeLa cells were investigated in order to examine the mechanisms of its anticancer activity. The measurement of intracellular ROS levels in HeLa and HaCaT cell lines were evaluated in order to explore their possible generation and the role in cytotoxic activity. The possible anti-invasive and anti-angiogenic properties of Cu(II) complex were evaluated. DNA binding experiments, including fluorescence displacement study and DNA cleavage experiments, were performed in order to obtain information on the type of DNA-metal complex interactions. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Formula: C5H5NOS

The Article related to copper complex antitumor agent acetylthiazole girard t reagent adenocarcinoma, Placeholder for records without volume info and other aspects.Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2022, Pekdemir, Fatih; Kocak, Izzet; Sengul, Abdurrahman published an article.Electric Literature of 24295-03-2 The title of the article was Copper(II) and Cobalt(II) Tridentate Complexes on Modified Graphene Oxide as Electrochemical Biosensors for Simultaneously Detecting Biomolecules. And the article contained the following:

Two novel coordination compounds, [Cu(L)Cl2] and [Co(L)Cl2] (L= 4-(6-hydroxy-phenyl)-2,6-di(thiazol-2-yl) pyridine), are successfully synthesized. The structure of the compounds was verified by instrumental techniques, including UV-visible spectroscopy, Fourier transform IR spectroscopy, proton NMR spectroscopy, and mass spectrometry. The graphene oxide, previously modified by spontaneous coupling of diazonium salt of 4-amino benzoic acid, was covalently bound with [Cu(L)Cl2] and [Co(L)Cl2] compounds The covalent attachment of the metallic complexes to the graphene oxide was confirmed by Fourier transform IR spectroscopy and cyclic voltammetry. Functionalized surfaces through metallic coordination compounds showed catalytic reactivity to individual electrochem. oxidation of ascorbic acid, dopamine, and uric acid as revealed by the enhancement in the anodic peak current and the shifted oxidation peak potentials of each three analytes in comparison to the plain glassy carbon and graphene oxide. The resulting electrodes were shown to be utilized for the simultaneous detection of ascorbic acid, dopamine, and uric acid due to the appearance of the well-separated and resolved three different anodic peaks. The sensitivity of both modified electrodes for each biol. compound was tested within the linear range of 2 to 15 μM for ascorbic acid, 0.2 to 3 μM for dopamine and uric acid, and the limit of detection values for ascorbic acid, dopamine, and uric acid are found to be 1.84 μM, 0.41 μM, and 0.32 μM, resp. for [Cu(L)Cl2] and 1.94 μM, 0.33 μM, and 0.52 μM for [Co(L)Cl2]. Furthermore, constructed electrochem. sensor platforms exhibited decent stability, selectivity, and reproducibility for the simultaneous detection of target biomols. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Electric Literature of 24295-03-2

The Article related to copper cobalt tridentate complex modified graphene oxide electrochem biosensor, Placeholder for records without volume info and other aspects.Electric Literature of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Hu, Min-Qi; Li, Heng; Lin, Ying; Zhang, Ying; Tang, Jie; Zuo, Jian-Ping; Yu, Li-Fang; Tong, Xian-Kun; Tang, Wei; Yang, Fan published an article in 2020, the title of the article was 1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors.Related Products of 92-36-4 And the article contains the following content:

Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Related Products of 92-36-4

The Article related to middle east respiratory syndrome 1phenyl n benzothiazol2yl methanimine derivative, Placeholder for records without volume info and other aspects.Related Products of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Rutkauskaite, Andzelika; White, Lisa J.; Hilton, Kira L. F.; Picci, Giacomo; Croucher, Lorraine; Caltagirone, Claudia; Hiscock, Jennifer R. published an article in 2022, the title of the article was Supramolecular self-associating amphiphiles: determination of molecular self-association properties and calculation of critical micelle concentration using a high-throughput, optical density based methodology.Synthetic Route of 92-36-4 And the article contains the following content:

Supramol. self-associating amphiphiles are a class of amphiphilic salt, the anionic component of which is ′frustrated′ in nature, meaning multiple hydrogen bonding modes can be accessed simultaneously. Here we derive critical micelle concentration values for four supramol. self-associating amphiphiles using the standard pendant drop approach and present a new high-throughput, optical d. measurement based methodol., to enable the estimation of critical micelle concentrations over multiple temperatures In addition, we characterize the low-level hydrogen bonded self-association events in the solid state, through single crystal X-ray diffraction, and in polar organic DMSO-d6 solutions using a combination of 1H NMR techniques. Moving into aqueous ethanol solutions (EtOH/H2O or EtOH/D2O (1 : 19 volume/volume)), we also show these amphiphilic compounds to form higher-order self-associated species through a combination of 1H NMR, dynamic light scattering and zeta potential studies. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Synthetic Route of 92-36-4

The Article related to supramol self associating amphiphile critical micelle concentration optical density, Placeholder for records without volume info and other aspects.Synthetic Route of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 5, 2021, El-Nahass, Marwa N. published an article.Electric Literature of 24295-03-2 The title of the article was D-π-A chalcone analogue as metal ions selective turn-on-off-on fluorescent chemosensor with cellular imaging and corrosion protection. And the article contained the following:

Novel naked eye optical chemosensor containing thiazole ring, namely; (2E,4E)-5-(4-(dimethylylamino)phenyl)-1-(thiazol-2-yl)penta-2,4-dien-1-one, DMAPTP was developed. The solvatochromic response was explored in different solvents of various polarities. The dipole moments in the ground (μg) and excited (μe) states were determined The large excited state dipole moment demonstrates the excited state′s stability in polar solvents. In an ethanolic solution, the sensing response and selectivity of the investigated chemosensor to various metal ions such as Na+, K+, Ca2+, Ba2+, Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Zn2+, Al3+, Hg2+, and Pb2+ were evaluated. The spectral changes suggest that DMAPTP is strongly complexed with the metal ions used. The ground and excited state binding constants, as well as the quenching constants, have been determined The mechanism of fluorescence quenching was identified as static quenching due to the formation of a non-fluorescent ground state complex using the Stern-Volmer plot. DMAPTP can also be used as a powerful chemosensor, identifying all of the metal ions studied with high sensitivity and selectivity for Fe3+ ions. DMAPTP can serve as a Turn-on-off-on chemosensor, as well as a metallochromic predictor in complexometric titration This is indicated by the ability of EDTA to decompose the formed complex with the formation of the stable metal-EDTA complex, which leads to fluorescence recovery. The anal. parameters, such as selectivity, sensitivity, and detection limit, were chosen. The fluorescence imaging experiments in living cells demonstrated the biol. chemosensing applications of DMAPTP to Fe3+ ions. Furthermore, weight loss, potentiodynamic polarization, electrochem. impedance spectroscopy, and SEM techniques were used to investigate DMAPTP as a corrosion inhibitor for carbon steel in 1.0 M HCl. The collected data reveal that as DMAPTP concentrations increased, its inhibition performance increased as well. On the basis of strong adsorption of inhibitor mols. on the surface of carbon steel and the formation of large protection films, the inhibition efficiencies were determined The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Electric Literature of 24295-03-2

The Article related to chalcone analog metal fluorescent chemosensor cellular imaging corrosion protection, Placeholder for records without volume info and other aspects.Electric Literature of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Aslam, Sana; Xi, Yun; Ahmad, Matloob; Mansha, Asim; Farooq, Tahir; Zheng, Zongheng; Saddique, Furqan Ahmad; Wang, Fang; Fu, Liwu published an article in 2020, the title of the article was Anticancer activity of structural hybrids of various 5/6-memberedheterocycles with pyrazolobenzothiazine 5,5-dioxide.Application In Synthesis of 2-Acetylthiazole And the article contains the following content:

Thiophene, furan, coumarin and pyrazolobenzothiazine are well familiar for their biol. activities. In this research, pyrazolobenzothiazine ring system is hybridized with various S, N & O-containing heterocycles and the resulting compounds were screened for their anticancer activity against six different cancer cell lines i.e., KB (human oral carcinoma cells), MCF-7(human breast carcinoma cells), A549 (human alveolar adenocarcinoma cells), Hep-G2 (liver carcinoma cells), SGC-7901(human gastric carcinoma cells) and S1 (human colon carcinoma cells) using MTT assay. Most of the compounds exhibited good activity against KB, S1 and A549 cancer cell lines. 5k and 5p appeared as potent inhibitors of KB cell line with IC50 values 2.78 and 4.39 μM resp., 5q was a potent inhibitor of MCF-7 (IC50 value = 13.64 μM) and 5j an excellent inhibitor of A549 cell line having IC50value of 1.03 μM. 5p and 5q were inhibitors of S1 cell line (IC50 values of 8.29 μM and 7.69 μM resp.), whereas, 5o and 5q as inhibitors of Hep-G2 cell line were discovered. A number of compounds show activity exceeding that of 5-fluoruracil in different cell assays. The most potently active compounds, 5j, 5p and 5q, exhibited selectivity in targeting cancerous cells as compared to normal human PBM cells while, 5k and 5o displayed significant toxicity in normal cells. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application In Synthesis of 2-Acetylthiazole

The Article related to human gastric liver colon carcinoma memberedheterocycle pyrazolobenzothiazine dioxide anticancer, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 15, 2020, Hooshyari, Khadijeh; Rezania, Hamidreza; Vatanpour, Vahid; Salarizadeh, Parisa; Askari, Mohammad Bagher; Beydaghi, Hossein; Enhessari, Morteza published an article.Name: 4-Phenylthiazol-2-amine The title of the article was High temperature membranes based on PBI/sulfonated polyimide and doped-perovskite nanoparticles for PEM fuel cells. And the article contained the following:

A new sulfonated aromatic diamine monomer containing nitrogen heterocycles was synthesized and employed to prepare a novel sulfonated polyimide (SPI). To develop proton exchange membranes, new nanocomposite blend membranes consist of the prepared SPI and polybenzimidazole (PBI) were fabricated with incorporation of SrCe0.9Yb0.1O3-δ (SCYb) doped-perovskite nanoparticles with a solution-casting method. The goal of this work is to study the effect of SPI and SCYb doped-perovskite nanoparticles on the important parameters of the PBI membrane specially proton conductivity and fuel cell performance. The proton conductivity and phosphoric acid doping level of the PBI-SPI-SCYb nanocomposite blend membranes improved due to an interaction of -SO3H group and thiazole rings of SPI and N-H groups of PBI in the oxygen vacancies of SCYb doped-perovskite nanoparticles. Substitution of Ce4+ by Yb3+ in the SCYb doped-perovskite nanoparticles produce oxygen vacancies and decrease the columbic repulsion between protons and pos. ions. Furthermore at highest phosphoric acid doping level of 14 mol phosphoric acid per monomer unit, the nanocomposite blend membranes displayed proton conductivity of 131 mS/cm at 180 °C and 8% relative humidity. The increase in power d. from 0.31 W/cm2 in PBI-SPI blend membranes (SPI/PBI: 25 wt%) to 0.59 W/cm2 in PBI-SPI-SCYb nanocomposite blend membranes (SPI/PBI: 25 wt% and 7 wt% of SCYb) was achieved at 0.5 V, 8% RH and 180 °C, which demonstrates that these developed nanocomposite blend membranes have a high potential to be regarded as the most promising candidates for high-temperature fuel cell with improved proton conductivity The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Name: 4-Phenylthiazol-2-amine

The Article related to polybenzimidazole sulfonated polyimide doped perovskite nanoparticle proton exchange membrane, fuel cell, Placeholder for records without volume info and other aspects.Name: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 28, 2022, Alamiery, Ahmed; Mohamad, Abu Bakar; Kadhum, Abdul Amir H.; Takriff, Mohd S. published an article.Electric Literature of 2010-06-2 The title of the article was Comparative data on corrosion protection of mild steel in HCl using two new thiazoles. And the article contained the following:

This data article includes data described in the investigation report entitled “The synergistic role of azomethine group and triazole ring at improving the anti-corrosive performance of 2-amino-4-phenylthiazole” (Alamiery et al., 2021). In this data article, a comprehensive effect of 2-Amino-4-phenyl-N-benzylidene-5-(1,2,4-triazol-1-yl)thiazole (APNT) and 2-amino-4-phenylthiazole (APT) and optimized process parameter of the inhibitor in 1 M HCl solution was presented using gravimetric techniques and D. functional theory. The presence of the inhibitors influenced the corrosion resistance of mild steel (MS). Inhibition efficiencies values of 98.1% and 94.74% were recorded as results of inhibition of the MS by the inhibiting compounds APNT and ATP resp. DFT studies observed that the presence of benzylidene to the APNT and the substitution of a triazole in the thiazole ring are adsorption sites that increase the interaction of the APNT mols. with the iron atoms on the MS surface. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to mild steel hydrogen chloride thiazole corrosion protection, corrosion, hydrochloric acid, inhibitor, mild steel, Placeholder for records without volume info and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Chai, Li-Juan; Fang, Guan-Yu; Xu, Peng-Xiang; Zhang, Xiao-Juan; Lu, Zhen-Ming; Zhang, Su-Yi; Wang, Song-Tao; Shen, Cai-Hong; Shi, Jin-Song; Xu, Zheng-Hong published an article in 2021, the title of the article was Novisyntrophococcus fermenticellae gen. nov., sp. nov., isolated from an anaerobic fermentation cellar of Chinese strong-flavour baijiu.Category: thiazole And the article contains the following content:

A Gram-stain-neg., coccus-shaped, obligately anaerobic, non-motile and non-spore-forming bacterium, designated strain JN500902T, was isolated from the mud in a fermentation cellar used continuously over 30 years for Chinese strong-flavor baijiu production Colonies were white, circular, convex and smooth-edged. Growth was observed at 20-40 °C (optimum, 37 °C), at pH 5.0-10 (optimum, pH 7.5), with 0-2% (w/v) NaCl and with 0-4% (volume/volume) ethanol. The Biolog assay demonstrated pos. reactions of strain JN500902T in the metabolism of l-fucose and pyruvate. The predominant cellular fatty acids (>10%) consisted of C16:0 and C14:0. The major end metabolites of strain JN500902T were acetic acid and ethanol when incubated anaerobically in liquid reinforced clostridial medium. Acetate was the major organic acid end product. The complete genome size of strain JN500902T was 3420321 bp with 3327 identified genes. The G + C content was 43.5 mol%. Phylogenetic anal. based on 16S rRNA gene sequences affiliated strain JN500902T with the family Lachnospiraceae, having low sequence similarity (92.8%) to the nearest type strain, Syntrophococcus sucromutans DSM 3224T and forming a clearly distinct branch. Core genome phylogenetic anal. of the isolate and 134 strains belonging to the family Lachnospiraceae also revealed that strain JN500902T was well-separated from other genera of this family as a monophyletic clade. The average nucleotide identity and amino acid identity values between strain JN500902T and 134 Lachnospiraceae strains were less than 74 and 65%, resp. Considering its polyphasic characteristics, strain JN500902T represents a novel genus and species within the family Lachnospiraceae, for which the name Novisyntrophococcus fermenticellae gen. nov., sp. nov. is proposed. The type strain is JN500902T (= CICC 24502T = JCM 33939T). The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Category: thiazole

The Article related to sequence novisyntrophococcus baijiu anaerobic fermentation cellar, lachnospiraceae, baijiu (chinese liquor), pit mud, Placeholder for records without volume info and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica