Month: November 2022

On April 30, 2021, Cho, Su-Hyeon; Kim, Song Rae; Jeong, Myeong Seon; Choi, Miri; Park, SeonJu; Kim, Kil-Nam published an article.Reference of 2-Acetylthiazole The title of the article was Protective Effect of Brassica napus L. Hydrosols against Inflammation Response in RAW 264.7 Cells. And the article contained the following:

To demonstrate the anti-inflammatory activity of Brassica napus L. hydrosols (BNH) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Composition anal. of BNH was conducted via gas chromatog.-mass spectrometry after BNH were extracted The nitric oxide (NO) production was measured using the Griess assay. Prostaglandin E2 (PGE2) production was evaluated with ELISA. The effects of BNH on LPS-induced pro-inflammatory enzymes including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were evaluated using Western blot anal. Furthermore, phosphorylation of nuclear factor-kappa B (NF-κB) and nuclear translocation of NF-κB p65 were evaluated with Western blot anal. and immunofluorescence staining, resp. Compared with LPS-stimulated cells, BNH markedly decreased the generation of NO and PGE2 in LPS-stimulated RAW 264.7 cells (P<0.01 or P<0.05). Moreover, BNH inhibited protein levels of iNOS and COX-2 (P<0.01). Phosphorylation of NF-κB and nuclear translocation of NF-κB p65 was significantly inhibited by BNH (P<0.01 or P<0.05). The anti-inflammatory activities of BNH were mediated via blockage of the NF-κB signaling pathways in LPS-stimulated RAW 264.7 cells. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Reference of 2-Acetylthiazole

The Article related to brassica napus hydrosols inflammation lipopolysaccharide, brassica napus l., raw 264.7 cells, hydrosols, inflammation, lipopolysaccharide, Placeholder for records without volume info and other aspects.Reference of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 30, 2019, Prashanth, T.; Avin, B. R. Vijay; Thirusangu, Prabhu; Ranganatha, V. Lakshmi; Prabhakar, B. T.; Sharath Chandra, J. N. Narendra; Khanum, Shaukath Ara published an article.Recommanded Product: 2010-06-2 The title of the article was Synthesis of coumarin analogs appended with quinoline and thiazole moiety and their apoptogenic role against murine ascitic carcinoma. And the article contained the following:

The synthesis and antiproliferative effect of a series of quinoline and thiazole containing coumarin analogs 12a-d and 13a-f resp., on mice leukemic cells was performed. The chem. structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectral anal. The result indicates that, 7-methoxy-2-oxo-2H-chromene-3-carboxylic acid [4-(4-methoxy-phenyl)-thiazol-2-yl]-amide (13f) showed potent activity against EAC and DLA cells in MTT (15.3 μM), tryphan blue (15.6 μM) and LDH (14.2 μM) leak assay with 5-fluorouracil as a standard Further, the anti-neoplastic effect of the compound 13f was verified against Ehrlich ascites tumor by BrdU incorporation, TUNEL, FACS and DNA fragmentation assays. Exptl. data showed that compound 13f induces the apoptotic cell death by activating apoptotic factors such as caspase-8 &-3, CAD, Cleaved PARP, γ-H2AX and by degrading genomic DNA of cancer cells and thereby decreasing the ascitic tumor development in mice. Besides, compound 13f was also subjected for docking studies to approve the in vitro and in vivo studies. The data revealed that the compound 13f has very good interaction with caspase 3 protein by binding with amino acid Arg 207 through hydrogen bond. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 2010-06-2

The Article related to ascitic carcinoma coumarin analog quinoline thiazole apoptosis mol docking, antiproliferation, coumarin, in vitro, in vivo, quinoline, thiazole, Placeholder for records without volume info and other aspects.Recommanded Product: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 30, 2022, Li, Jing; Yang, Youyou; Tang, Chaohua; Yue, Shengnan; Zhao, Qingyu; Li, Fadi; Zhang, Junmin published an article.Synthetic Route of 24295-03-2 The title of the article was Changes in lipids and aroma compounds in intramuscular fat from Hu sheep. And the article contained the following:

I.m. fat (IMF) content is associated with lamb flavor and largely varies between individuals of the same breed. However, studies investigating the effects of IMF variations on lipid profiles and aroma compounds are limited. Here, we performed lipidomic and volatilomic profiling of high-IMF and low-IMF Hu lambs. Triglycerides and diglycerides in the high-IMF group were significantly higher than those in the low-IMF group (p < 0.05). Seventy-nine of 842 lipids identified were significantly different between the groups under pos. and neg. ion modes (variable importance in projection > 1, p < 0.05). Volatilomic analyses revealed that the aroma profiles also differed between the groups. Fifteen aroma compounds, mainly originating from lipid oxidation, could be responsible for this difference. Thus, our findings provide a comprehensive understanding of the increases in IMF content that drive consumers′ satisfaction and also provide a basis for underpinning breeding value for IMF. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Synthetic Route of 24295-03-2

The Article related to lipid aroma compound intramuscular fat hu sheep, intramuscular fat, lipid profile, lipidomics, odorant, partial least squares regression, volatilomics, Placeholder for records without volume info and other aspects.Synthetic Route of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 30, 2021, Al-Hamashi, Ayad A.; Koranne, Radhika; Dlamini, Samkeliso; Alqahtani, Abdulateef; Karaj, Endri; Rashid, Maisha S.; Knoff, Joseph R.; Dunworth, Matthew; Pflum, Mary Kay H.; Casero, Robert A. Jr; Perera, Lalith; Taylor, William R.; Tillekeratne, L. M. Viranga published an article.COA of Formula: C5H5NOS The title of the article was A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics. And the article contained the following:

Despite the advances in treatment strategies, cancer is still the second leading cause of death in the USA. A majority of the currently used cancer drugs have limitations in their clin. use due to poor selectivity, toxic side effects and multiple drug resistance, warranting the development of new anticancer drugs of different mechanisms of action. Here we describe the design, synthesis and initial biol. evaluation of a new class of antimitotic agents that modulate tubulin polymerization Structurally, these compounds are chalcone mimics containing a 1-(1H-imidazol-2-yl)ethan-1-one moiety, which was initially introduced to act as a metal-binding group and inhibit histone deacetylase enzymes. Although several analogs selectively inhibited purified HDAC8 with IC50 values in low micromolar range, tissue culture studies suggest that HDAC inhibition is not a major mechanism responsible for cytotoxicity. The compounds demonstrated cell growth inhibition with GI50 values of upper nanomolar to low micromolar potency with significant selectively for cancer over normal cells. Interestingly, several compounds arrested HeLaM cells in mitosis and seem to target tubulin to cause mitotic arrest. For example, when combined with inhibitors of Aurora B kinase, they led to dramatic disassembly of the mitotic spindle. In-vitro tubulin polymn studies showed that the compounds reduced the rate of polymn of microtubules during the elongation phase and lowered the amt of polymd tubulin during the plateau phase. Finally, in silico docking studies identified binding of (E)-2-(4-(3-(1H-Imidazol-2-yl)-3-oxoprop-1-en-1-yl)phenyl)-N-(4-fluorophenyl)acetamide to the colchicine site with similar affinity as the test compound D64131. These compounds represent a new antimitotic pharmacophore with limited HDAC inhibitory activity. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).COA of Formula: C5H5NOS

The Article related to chalcone mimic antitumor antimitotic tubulin disruption microtubule dynamic, anticancer agents, antimitotic agents, chalcones, mitotic arrest, mitotic spindle, Placeholder for records without volume info and other aspects.COA of Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 31, 2021, Hou, Lixia; Chen, Liyan; Song, Pinqing; Zhang, Yujin; Wang, Xuede published an article.Name: 2-Acetylthiazole The title of the article was Comparative assessment of the effect of pretreatment with microwave and roast heating on the quality of black sesame pastes. And the article contained the following:

Heating is a key procedure in producing sesame paste. The effects of microwave heating and conventional roasting on the physicochem. features, protein profiles, and volatile compounds of black sesame pastes made of black sesame seeds from Burma and China were evaluated in this study. All heating treatments decreased the moisture contents of black sesame pastes, and roasting yielded lower moisture levels, although with similar chroma (p < 0.05). The samples subjected to microwave heating had remarkably lower peroxide values than those heated with roasting (p < 0.05). Chinese microwave-heated samples had a higher nitrogen solubility index than roasting (p < 0.05). Both microwave and roasting increased the contents of the volatiles notably. SDS-PAGE showed that the intensity of the 2-15 kDa band decreased markedly after heating and nearly diminished for roasting samples, suggesting that roasting was more remarkable for the promotion to the protein aggregation. The results indicated that the quality traits of black sesame paste not only depend on the heating methods, but also the heating power/temperature and duration, and the source of the materials. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Name: 2-Acetylthiazole

The Article related to microwave roast heating black sesame paste quality pretreatment effect, black sesame, microwave heating, physicochemical properties, roasting, volatile compounds, Placeholder for records without volume info and other aspects.Name: 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ma, Yu-Nan; Chen, Chuan-Jiao; Li, Qing-Qing; Xu, Fu-Rong; Cheng, Yong-Xian; Dong, Xian published an article in 2019, the title of the article was Monitoring antifungal agents of Artemisia annua against Fusarium oxysporum and Fusarium solani, associated with panax notoginseng root-rot disease.Product Details of 2010-06-2 And the article contains the following content:

Root rot of Panax notoginseng has received great attention due to its threat on the plantation and sustainable utilization of P. notoginseng. To suppress the root-rot disease, natural ingredients are of great importance because of their environment friendly properties. In this study, we found that the methanol extract from Artemisia annua leaves has strong antifungal effects on the growth of Fusarium oxysporum and Fusarium solani resulting into root-rot disease. Essential oil (EO) thereof was found to be the most active. GC-MS anal. revealed 58 ingredients and camphor, camphene, β-caryophyllene, and germacrene D were identified as the major ingredients. Further antifungal assays showed that the main compounds exhibit various degrees of inhibition against all the fungi tested. In addition, synergistic effects between A. annua EO and chem. fungicides were examined Finally, in vivo experiments were conducted and disclosed that P. notoginseng root rot could be largely inhibited by the petroleum ether extract from A. annua, indicating that A. annua could be a good source for controlling P. notoginseng root-rot. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Product Details of 2010-06-2

The Article related to panax fusarium artemisia root rot disease essential oil antifungal, artemisia annua, fusarium oxysporum, fusarium solani, panax notoginseng, essential oil, root rot, Placeholder for records without volume info and other aspects.Product Details of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shaik, Shaheen; Vasa, Sreeja published an article in 2022, the title of the article was Synthesis, characterization and evaluation of semisynthetic derivatives of lawsone.Name: 4-Phenylthiazol-2-amine And the article contains the following content:

Quinones are widely distributed in nature, and several of their synthetic and natural products are very important in many diverse areas of chem. and biochem. They play a fundamental role in several living cells as electron carriers in the respiratory chain, as well as in blood coagulation and carboxylation of glutamates. Due to the intimate relationship between quinones and the biochem. processes of cells, these compounds have been extensively explored in the synthesis 2 of several bioactive compounds with antitumor, molluscicidal, antiparasitic, leishmanicidal, antiinflammatory, antifungal, antimicrobial and trypanocidal activities. In the present work we have synthesized semisynthetic derivatives of lawsone 2(a-d) by Mannich base reaction. Four derivatives of Lawson were synthesized. All the compounds synthesized were obtained in good yields. Purity of compounds was confirmed by TLC and m.ps. and compounds were characterized by preliminary laboratory techniques like chem. tests, m.p., Rf. The synthesized compounds were screened for wound healing activity. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Name: 4-Phenylthiazol-2-amine

The Article related to lawsone semisynthetic derivative synthesis, Pharmaceuticals: Formulation and Compounding and other aspects.Name: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 25, 2020, Han, Amy; Kelly, Marcus; Olson, William published a patent.Category: thiazole The title of the patent was Tubulysins and protein-tubulysin conjugates. And the patent contained the following:

Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with cancer, including tubulysins and protein (e.g., antibody) drug conjugates thereof. The experimental process involved the reaction of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate(cas: 944559-46-0).Category: thiazole

The Article related to tubulysin protein conjugate antibody cancer, Pharmaceuticals: Formulation and Compounding and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 21, 2021, Kshirsagar, Rajendra R.; Gadekar, Pradip K.; Khedkar, Vijay M.; Vijayakumar, Vijayaparthasarathi published an article.Electric Literature of 2010-06-2 The title of the article was Design, Synthesis, and the Effects of (E)-9-Oxooctadec-10-en-12-ynoic Acid Analogues to Promote Glucose Uptake. And the article contained the following:

(E)-9-Oxooctadec-10-en-12-ynoic acid is found to mediate its antidiabetic activity by increasing insulin-stimulated glucose uptake in L6 myotubes by activating the phosphoinositide 3-kinase (PI3K) pathway. A simultaneous study of site-specific modification followed by structure-activity relationship provides a tremendous scope for exploiting the bioactivity of the parent mol. Therefore, in the present study, we focused on site-specific modification of (E)-9-oxooctadec-10-en-12-ynoic acid (1) to generate multiple derivatives and extensive structure-activity relationship (SAR) studies. We have done structural base design and synthesized a series of amides from acid compound 1. Compound 1 consists of an acid functionality, which is known for its metabolism-related liabilities. The SAR has been generated using scaffolds of different antidiabetic drugs such as biguanides, sulfonylureas, thiazolidinediones/glitazones, peroxisome proliferator-activated receptors, K + ATP, α-glucosidase inhibitors, and others. Furthermore, the study demonstrates and explains the promising derivatives and importance of SAR of the compound (E)-9-oxooctadec-10-en-12-ynoic acid. In order to gain mechanistic insights, a mol. docking study was performed against PI3K, which could identify the binding modes and thermodn. interactions governing the binding affinity. According to our research,some compounds are the best compounds from the series having EC50 values of 15.47, 8.89, 7.00, 13.99, 8.70, 12.27, and 16.14μM, resp. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to oxooctadecenynoic acid analog preparation antidiabetic activity, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 31, 2007, Ichihara, Osamu; Sampson, David; Whittaker, Mark; Bradley, Mark; Cho, Jin Ku published an article.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole The title of the article was Development of self-indicating resin. And the article contained the following:

The development and application of self-indicating resins (SIR), materials which can indicate the presence or absence of amines in the reaction solution by the conspicuous color change of a phenolsulfophthalein type dye immobilized on resin beads has been reported. Although the functionality necessary for attaching the dye to the resins could be readily introduced by the Suzuki-Miyaura coupling during the synthesis of the SIR, this approach was only applicable to the dyes containing suitable functionality for the cross-coupling reaction. A new approach to immobilizing the indicating dyes onto the resin support is now reported. The dyes suitable for loading onto aminomethyl polystyrene (PS) resin were prepared by Friedel-Crafts reaction of 2-sulfoterephthalic anhydride with a wide range of phenols. Using this new route, polymer-supported dye I was readily prepared in >100g quantities. Use of I in the synthesis of a 144 member urea library was demonstrated and the SIR successfully indicated the endpoint of the reaction between amines and isocyanates. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to urea preparation sulfonephenolphthalein polymer supported indicator, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica