Month: November 2022

Lin, Wei-Liang; Lin, Chung-Yin; Tai, Dar-Fu published an article in 2021, the title of the article was Preparation of a Molecularly Imprinted Film on Quartz Crystal Microbalance Chip for Determination of Furanic Compounds.Computed Properties of 24295-03-2 And the article contains the following content:

The structural preferences of furanic compounds were studied using a combination of a molecularly imprinted film (MIF) on a piezoelec.-quartz chip. The furanic compounds and their derivatives were used as the templates. Owing to their similar heterocyclic structures, it is difficult to verify the structural differences between the templates. Therefore, a new cross-linker (Methacr-l-Cys-NHBn)2, was employed to generate a platform on a quartz crystal microbalance (QCM) chip. The cross-linker self-assembled to link the surface of the chip to copolymerize with other functional monomers. A layered film with chiral hydrophobicity and rigidity was thus fabricated. Subsequently, Acr-l-Ser-NHBn was utilized as a chiral monomer to construct MIF on a QCM chip. Forcomparison, we synthesized a more hydrophobic monomer, Methacr-l-Ser-NHBn, to enhance the binding ability of the MIF. The QCM flow injection system was handled in an organic solvent system. The proportion of the monomers was adjusted to optimize the recognition ability of these films. As the binding ability of the MIF toward model templates and structurally-related furanic compounds was improved, a MIF derived from 2-furaldehyde (FUL) achieved a lower detection limit (10 ng/mL). The binding properties of MIFs prepared against furanic compounds exhibited strong similarities to the binding properties of other compounds with heterocyclic ring structures. For example, 2-furaldehyde is very similar to 2-formylthiazole, 2-acetylfuran is similar to 2-acetylthiazole, and 2-furfuryl alc. is similar to imidazole-2-methanol. Such recognition ability can help distinguish between the structural counterparts of other small heterocyclic compounds The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Computed Properties of 24295-03-2

The Article related to quartz crystal chip molecularly imprinted film furanic compound determination, Organic Analytical Chemistry: Determinations and other aspects.Computed Properties of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sahni, Tanvi; Sharma, Sunita; Verma, Diksha; Kaur, Harleen; Kaur, Amanpreet published an article in 2022, the title of the article was Synthesis and in vitro Fungitoxic Evaluation of Syringaldehyde Schiff Bases and β-Lactams.Safety of 4-Phenylthiazol-2-amine And the article contains the following content:

Syringic Schiff bases I [R = Ph, Bn, 2-pyridyl, etc.] were synthesized by condensation of syringaldehyde with a number of amines, and in exploratory work two β-lactams II and III were further prepared from their progenitor 4-aminoantipyrene and 4-aminophenol imines. All the compounds were fully characterized and evaluated for their fungitoxicity against four principal phytopathogenic fungi of maize, namely R. solani, D. maydis, M. phaseolina and F. verticilloides. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Safety of 4-Phenylthiazol-2-amine

The Article related to syringaldehyde schiff base preparation antifungal, beta lactam preparation antifungal, General Organic Chemistry: Synthetic Methods and other aspects.Safety of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 22, 2011, Zanda, Matteo; Sani, Monica; Lazzari, Paolo published a patent.Recommanded Product: Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate The title of the patent was Pharmaceutical compositions comprising tubulysin compounds. And the patent contained the following:

The present invention relates to synthetic tubulysin compounds having a high cytotoxicity, with antimitotic and/or antiangiogenic properties, the corresponding solvates and pharmaceutically acceptable salts thereof, their use for the treatment of tumors and/or diseases associated to angiogenesis, and a process for their preparation with high yield. Pharmaceutical compositions comprising tubulysin compounds or their conjugates with polymers or biomols., e.g., proteins, hormones, aptamers, polysaccharides, antibodies and fragments thereof, peptides, vitamins, etc., are disclosed. Thus, (2S,4R)-4-[2-[(1R,3R)-1-acetoxy-3-[(2S,3R)-N-benzyl-3-methyl-2-(1-methylpiperidine-2-carboxamido)pentanamido]-4-methylpentyl]thiazole-4-carboxamido]-2-methyl-5-phenylpentanoic acids was prepared and formulated into nanoparticles of polylactate-polyglycolate copolymer. The high cytotoxicity of the compound against 3 tumor cell lines (HL60, HT29 and A2780) was demonstrated. The experimental process involved the reaction of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate(cas: 944559-46-0).Recommanded Product: Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate

The Article related to tubulysin compound preparation antitumor antimitotic angiogenesis inhibitor pharmaceutical, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 3, 2021, Trofymchuk, Serhii; Bugera, Maksym; Klipkov, Anton A.; Ahunovych, Volodymyr; Razhyk, Bohdan; Semenov, Sergey; Boretskyi, Andrii; Tarasenko, Karen; Mykhailiuk, Pavel K. published an article.HPLC of Formula: 24295-03-2 The title of the article was Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF4). And the article contained the following:

A general approach to fluorinated (hetero)aromatic derivatives was elaborated. The key reaction was a deoxofluorination of substituted acetophenones with sulfur tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation was fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chem. and agrochem., were synthesized. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).HPLC of Formula: 24295-03-2

The Article related to fluorinated aromatic compound preparation, aryl ketone deoxofluorination sulfur tetrafluoride, General Organic Chemistry: Synthetic Methods and other aspects.HPLC of Formula: 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

White, Lisa J.; Boles, Jessica E.; Hilton, Kira L. F.; Ellaby, Rebecca J.; Hiscock, Jennifer R. published an article in 2020, the title of the article was Towards the application of supramolecular self-associating amphiphiles as next-generation delivery vehicles.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole And the article contains the following content:

Herein, we present a series of supramol. self-associating amphiphilic (SSA) salts and establish the potential for these mol. constructs to act as next-generation solution-state mol. delivery vehicles. We characterize the self-association of these SSAs, both alone and when co-formulated with a variety of drug(like) competitive guest species. Single crystal X-ray diffraction studies enable the observation of hydrogen-bonded self-association events in the solid state, while high resolution mass spectrometry confirms the presence of anionic SSA dimers in the gas-phase. These same anionic SSA dimeric species are also identified within a competitive organic solvent environment (DMSO-d6/0.5% H2O). However, extended self-associated aggregates are observed to form under aqueous conditions (H2O/5.0% EtOH) in both the absence and presence of these competitive guest species. Finally, through the completion of these studies, we present a framework to support others in the characterization of such systems. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to drug delivery self associating amphiphile, amphiphile, drug delivery, hydrogen bond, supramolecular chemistry, Pharmaceuticals: Formulation and Compounding and other aspects.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 31, 2022, Verma, Diksha; Sharma, Sunita; Sahni, Tanvi; Kaur, Harleen; Kaur, Sukhmanpreet published an article.Synthetic Route of 2010-06-2 The title of the article was Designing, antifungal and structure activity relationship studies of Azomethines and β-lactam derivatives of aza heterocyclic amines. And the article contained the following:

The present investigation deals with the synthesis of seven azomethine derivatives I [R1 = 1,2,4-triazol-4-yl, 2-pyridinyl, 4-phenyl-2-thiazolyl,etc.] of aza heterocyclic amines by carrying out condensation reaction of them with veratraldehyde followed by cyclizing the CH=N moiety in synthesized azomethines of 4-amino-1,2,4-triazole and 4-amino antipyrine to yield β lactam derivatives II [R2 = 1,2,4-triazol-4-yl, 1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl]. The chem. constituents in the synthesized compounds were confirmed by UV, IR, 1H NMR, 13C NMR, and elemental anal. In vitro antifungal activity of all the synthesized products was done against four pathogenic maize fungal strains i.e.Fusarium verticillioides, Macrophomina phaseolina, Rhizoctonia solani, and Dreschlera maydis. It was found that azomethine derivative having 4-amino-1,2,4-triazole ring was as effective as standard carbendazim 50 WP against R. solani and may be considered as promising antifungal agent; therefore further modifications may be done in its structure to get better drug candidate in future. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Synthetic Route of 2010-06-2

The Article related to dimethoxyphenyl methanimine preparation agrochem antifungal sar, dimethoxyphenylazetidinone preparation agrochem antifungal sar, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 28, 2021, Tu, Dewei; Luo, Juan; Jiang, Wengao; Tang, Qiang published an article.Electric Literature of 24295-03-2 The title of the article was Solvent-free preparation of α,α-dichloroketones with sulfuryl chloride. And the article contained the following:

An efficient and facile method is reported for the synthesis of a series of α,α-dichloroketones. The direct dichlorination of Me ketones and 1,3-dicarbonyls using an excess amount of sulfuryl chloride affords the corresponding gem-dichloro compounds in moderate to excellent yields. Moreover, the protocol features high yields, broad substrate scope and simple reaction conditions without using any catalysts and solvents. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Electric Literature of 24295-03-2

The Article related to chlorination methyl ketone sulfuryl chloride, carbonyl compound sulfuryl chloride solvent free chlorination, dichloroketone preparation, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Thomson, Connor J.; Barber, David M.; Dixon, Darren J. published an article in 2020, the title of the article was Catalytic Enantioselective Direct Aldol Addition of Aryl Ketones to α-Fluorinated Ketones.Electric Literature of 24295-03-2 And the article contains the following content:

The catalytic enantioselective synthesis of α-fluorinated chiral tertiary alcs. from (hetero)aryl Me ketones is described. The use of a bifunctional iminophosphorane (BIMP) superbase was found to facilitate direct aldol addition by providing the strong Bronsted basicity required for rapid aryl enolate formation. The new synthetic protocol is easy to perform and tolerates a broad range of functionalities and heterocycles with high enantioselectivity (up to >99:1 e.r.). Multi-gram scalability was demonstrated along with catalyst recovery and recycling. 1H NMR studies identified a 1400-fold rate enhancement under BIMP catalysis, compared to the prior state-of-the-art catalytic system. The utility of the aldol products was highlighted with the synthesis of various enantioenriched building blocks and heterocycles, including 1,3-aminoalc., 1,3-diol, oxetane, and isoxazoline derivatives The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Electric Literature of 24295-03-2

The Article related to enantioselective catalyst aldol aryl ketone alpha fluorinated, aldol, aryl enolates, enantioselective catalysis, organocatalysis, superbase, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 4, 2021, Polishchuk, Iuliia; Sklyaruk, Jan; Lebedev, Yury; Rueping, Magnus published an article.Application In Synthesis of 2-Acetylthiazole The title of the article was Air Stable Iridium Catalysts for Direct Reductive Amination of Ketones. And the article contained the following:

Half-sandwich iridium complexes bearing bidentate urea-phosphorus ligands I and II were found to catalyze the direct reductive amination of aromatic and aliphatic ketones e.g.,2-Naphthyl Me ketone under mild conditions at 0.5 mol% loading with high selectivity towards primary amines e.g.,1-(naphthalen-2-yl)ethan-1-amine. One of the complexes I was found to be active in both the Leuckart-Wallach (H4CO2H) type reaction as well as in the hydrogenative (H2/NH4AcO) reductive amination. The protocol with ammonium formate does not require an inert atm., dry solvents, as well as additives and in contrast to previous reports takes place in hexafluoroisopropanol (HFIP) instead of methanol. NH4CO2D or D2 is resulted in a high degree of deuterium incorporation into the primary amine α-position. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application In Synthesis of 2-Acetylthiazole

The Article related to primary amine preparation, ketone reductive amination iridium catalyst, deuteration, iridium catalysis, primary amines, reductive amination, General Organic Chemistry: Synthetic Methods and other aspects.Application In Synthesis of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 6, 2022, Dong, Yuyang; Schuppe, Alexander W.; Mai, Binh Khanh; Liu, Peng; Buchwald, Stephen L. published an article.Related Products of 24295-03-2 The title of the article was Confronting the Challenging Asymmetric Carbonyl 1,2-Addition Using Vinyl Heteroarene Pronucleophiles: Ligand-Controlled Regiodivergent Processes through a Dearomatized Allyl-Cu Species. And the article contained the following:

A CuH-catalyzed regiodivergent coupling of vinyl heteroarenes with carbonyl-containing electrophiles, in which the selectivity was controlled by the ancillary ligand. This approach leverages an in situ generated benzyl- or dearomatized allyl-Cu intermediate, yielding either the dearomatized or exocyclic addition products, resp. The method exhibited excellent regio-, diastereo-, and enantioselectivity and tolerated a range of common functional groups and heterocycles. The dearomative pathway allowed direct access to a variety of functionalized saturated heterocyclic structures. The reaction mechanism was probed using a combination of exptl. and computational approach. D. functional theory studies suggested that the ligand-controlled regioselectivity results from the C-H/π interaction and steric repulsion in transition states leading to the major and minor regioisomers, resp. Hydrocupration of vinyl heteroarene pronucleophile was the enantiodetermining step, whereas the diastereoselectivity was enforced by steric interactions between the benzylic or allyl-Cu intermediate and carbonyl-containing substrates in a six-membered cyclic transition state. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Related Products of 24295-03-2

The Article related to vinyl hetero arene aldehyde ketone copper catalyst reductive coupling, hydroxy vinyl heteroarene regio diastereo enantioselective preparation, General Organic Chemistry: Synthetic Methods and other aspects.Related Products of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica