Month: November 2022

On November 20, 2008, Richter, Wolfgang published a patent.COA of Formula: C12H15NO3S The title of the patent was Preparation of tubulysine derivatives for treatment of cancer. And the patent contained the following:

The invention relates to novel cytotoxic peptides R1R2NCR3R4CONHCR5R6CONR7CR8R9-X-CHR10-A-CONHR11 [A is an optionally-substituted 5- or 6-membered heteroaryl ring; X is O, S, NR12, CR13R14, or CH2CR13R14; R1-R6, R8-R10, R12-R14 are independently H, optionally substituted alk(en)(yn)yl, aryl, heteroaryl, cycloalkyl, etc.; or two R groups form (hetero)cycloalkyl; R7 is alkyl, oxaalkyl, alkanoyl, CH2OCOPh, alkylaminoalkyl, hydroxyalkyl, etc.; R11 is -CH(CH2R15)(CH2)0-3CHR16R17, where R15 is optionally substituted aryl, heteroaryl, heterocycloalkyl,heteroalkylcycloalkyl, or heteroaralkyl;R16 is H, optionally alkyl, aryl, or heteroaryl;R17 is CO2H or ester, CONHNH2, OH, NH2, SH, or optionally substituted alkyl, cycloalkyl, heteroalkyl, orheterocycloalkyl] and their use for the treatment of cancer and other diseases. Thus, peptide I was prepared by a multistep procedure involving peptide coupling in solution Compounds of the invention show an activity against several cancer cell lines between 0.03 to 60 nM. The experimental process involved the reaction of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate(cas: 944559-46-0).COA of Formula: C12H15NO3S

The Article related to peptide tubulysine derivative preparation treatment cancer, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.COA of Formula: C12H15NO3S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 5, 2022, Odey, Joseph O.; Ubana, Emmanuel I.; Eko, Ishegbe J.; Jones, Okama O. published an article.Electric Literature of 2010-06-2 The title of the article was Synthesis, characterization and theoretical studies of the photovoltaic properties of novel bifunctional reactive disperse dyes based on aminothiazole derivatives. And the article contained the following:

This article comprises synthesis and characterization of two polyfunctional diazo reactive-disperse dyes with aminothiazole moiety for application in dye-sensitized solar cells (DSSC). The characterization techniques employed were Gas chromatog.-mass spectrometry (GC-MS), Fourier-transform IR spectroscopy (FT-IR), UV-visible spectroscopy (UV-vis), and NMR to determine the different functional groups, mol. connectivities and mol. weight of the various fragments of the synthesized dyes. Theor. D. Functional Theory (DFT) and Time-Dependent TD-DFT calculations were performed using B3LYP/6-311+g(d,p). It can be observed that the HOMO energy levels of the resp. dyes have lower values than I-/I3- redox couple level (around -4.80 eV) in the four different phases studied, which is crucial for the regeneration of the oxidized dye mol. and efficient charge separation Furthermore, the HOMO-LUMO energy gaps of DYES F and S are within the range 2.38-5.40 eV, where all LUMO-CB of TiO2 energy gap values are sufficient for generating enough driving force for effective electron injection. The promising results of Light-harvesting efficiency (LHE) (values ranging from 0.81 to 0.89 except for DYE S in chloroform phase where it has an unusual value of 0.21) and Open-circuit voltage (VOC) values gotten compared with other organic, and natural sensitizers were due to the better interaction between the carboxyl and carbonyl groups of aryl azo mol. joined to the thiazolyl nucleus and the surface of TiO2 permeable film. DYE S exhibits the lowest band gap (2.374eV), which designates the highest chem. activity of the two dyes. Results from the quantum theory of atoms-in-mols. indicate that DYES F and S exhibit addnl. stability due to their relatively high H-bond interactions as well as certain addnl. intra-at. bonds among the atoms of the investigated compounds The outcome of the Natural bond orbital (NBO) anal. suggests that the strongest charge transfer occurs in DYE S as compared to DYE F. The types and modes of excitations for the first five excited states of the synthesized dyes were observed from the results of the hole-electron excitation anal. First hyperpolarizability values of the dye F and dye S were determined to be 47.24 and 46.90 times the hyperpolarizability value of urea, demonstrating its excellent non-linear optical (NLO) response. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to bifunctional aminothiazole dye preparation dssc electron transfer nlo, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 10, 2014, Margathe, Jean-Francois; Iturrioz, Xavier; Alvear-Perez, Rodrigo; Marsol, Claire; Riche, Stephanie; Chabane, Hadjila; Tounsi, Nassera; Kuhry, Maxime; Heissler, Denis; Hibert, Marcel; Llorens-Cortes, Catherine; Bonnet, Dominique published an article.Safety of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the article was Structure-Activity Relationship Studies toward the Discovery of Selective Apelin Receptor Agonists. And the article contained the following:

Apelin is the endogenous ligand for the previously orphaned G protein-coupled receptor APJ. Apelin and its receptor are widely distributed in the brain, heart, and vasculature, and are emerging as an important regulator of body fluid homeostasis and cardiovascular functions. To further progress in the pharmacol. and the physiol. role of the apelin receptor, the development of small, bioavailable agonists and antagonists of the apelin receptor, is crucial. In this context, E339-3D6 was described as the first nonpeptidic apelin receptor agonist. The authors show here that 1 is actually a mixture of polymethylated species, and they describe an alternative and versatile solid-phase approach that allows access to highly pure 27, the major component of 1. This approach was also applied to prepare a series of derivatives in order to identify the crucial structural determinants required for the ligand to maintain its affinity for the apelin receptor as well as its capacity to promote apelin receptor signaling and internalization. The study of the structure-activity relationships led to the identification of ligands 19, 21, and 38, which display an increased affinity compared to that of 27. The latter and 19 behave as full agonists with regard to cAMP production and apelin receptor internalization, whereas 21 is a biased agonist toward cAMP production Interestingly, the three ligands display a much higher stability in mouse plasma (T1/2 > 10 h) than the endogenous apelin-17 peptide 2 (T1/2 < 4 min). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Safety of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to apelin receptor ligand fluorescent peptide solid phase preparation sar, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Safety of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ghabbour, Hazem A.; Fahim, Asmaa M.; Abu El-Enin, Mohammed A.; Al-Rashood, Sara T.; Abdel-Aziz, Hatem A. published an article in 2022, the title of the article was Crystal structure, Hirshfeld surface analysis and computational study of three 2-(4-arylthiazol-2-yl)isoindoline-1,3-dione derivatives.COA of Formula: C9H8N2S And the article contains the following content:

In these studies, we investigated the importance of isoindoline in pharmacol. evaluation, so we studied the crystal structure, packing, Hirshfeld anal. and computational calculations of 2-(4-arylthiazol-2-yl)isoindoline-1,3-dione derivatives . All single crystal structures of these isoindoline-1,3-dione were shown monoclinic system; P21/n space group and their net diploe moment 2.20, 3.73, 2.02 Debye, resp. Furthermore, Hirshfeld surface anal. was useful technique for visualization and analyze the intermol. interaction between atoms in mol., therefore, the isoindoline derivatives showed different contacts were mostly in H….H range (24.4%-36.5%), H range (8.7%-121.1%), S….H range (4.5%-5.6%) and C….H range (5.4%-10.6%); resp. The isoindoline 4c showed higher intermol. interaction dur to presence of two OCH3 groups. These single crystal structures of dione derivatives were comparable with theor. studies utilized DFT/6-311(G)d,p basis set and determination their phys. descriptors, MEP, HOMO-LUMO band energy gap and charge distribution. Moreover, the correlation studies of the 1HNMR spectral anal. between exptl. and theor. and they were excellent fitted with each other’s. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).COA of Formula: C9H8N2S

The Article related to arylthiazole iosindolinedione crystal structure homo lumo nmr chem shift, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.COA of Formula: C9H8N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 31, 2019, Farahati, Razieh; Ghaffarinejad, Ali; Mousavi-Khoshdel, S. Morteza; Rezania, Jafar; Behzadi, Hadi; Shockravi, Abbas published an article.Application In Synthesis of 4-Phenylthiazol-2-amine The title of the article was Synthesis and potential applications of some thiazoles as corrosion inhibitor of copper in 1 M HCl: Experimental and theoretical studies. And the article contained the following:

Thiazoles continue to attend in synthetic organic chem. due to their wide applications in the development of corrosion inhibitors. This study presents synthesis and corrosion inhibition ability of three thiazoles-4-(2-aminothiazole-4-yl) phenol (ATP), 4-phenylthiazole-2-amine (PTA) and 4,4′-(thiobis(2-aminothiazole-5,4-diyl)) diphenol (TATD) on the copper surface, where TATD is a dimer form of ATP. The inhibition efficiencies were evaluated by potentiodynamic polarization, electrochem. impedance spectroscopy (EIS), at. force microscopy (AFM) and SEM (SEM) in various concentrations of thiazoles containing 1 M HCl solution Computational studies (d. functional theory (DFT) and mol. dynamics (MD) simulation) were also performed. The corrosion inhibition efficiencies of these compounds at optimum concentration were about 90%, indicating that ATP, PTA and TATD could be employed as effective corrosion inhibitors. Comparing the corrosion inhibition efficiencies of monomer ATP and dimer form TATD of thiazole also indicated that dimerization of inhibitor did not cause better interaction with the copper surface and more efficiency. The adsorption of inhibitors could be successfully described by the Langmuir adsorption isotherm. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application In Synthesis of 4-Phenylthiazol-2-amine

The Article related to phenylthiazole copper adsorption potential energy corrosion inhibition ir spectra, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Application In Synthesis of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 1, 2001, Lehmann, Thomas; Fischer, Ruediger; Albers, Markus; Roelle, Thomas; Mueller, Gerhard; Hessler, Gerhard; Tajimi, Masaomi; Ziegelbauer, Karl; Okigami, Hiromi; Bacon, Kevin; Hasegawa, Haruki published a patent.Product Details of 64987-16-2 The title of the patent was Preparation of cyclic carboxylic acid peptides as integrin antagonists. And the patent contained the following:

Peptides R6-X-A-N(R5)CR3R4-Y-DR1R2 [R1 represents a 4-9-membered (un)saturated aromatic cyclic residue which can contain 0-3 heteroatoms N, S or O and may be annulated and/or substituted; R2, R3, R4 and R5 represent H or (un)substituted C1-C10 alkyl, C2-C10 alkenyl or alkynyl, C6 or C10 aryl, C3-C7 cycloalkyl or a 4-9-membered (un)saturated heterocyclic residue containing up to 2 atoms O, N or S; R6 represents Ph or a 5- to 6-membered aromatic heterocyclic residue containing up to 3 atoms O, N and S and which may annulated or substituted; A represents CO, COCO, SO, SO2, PO, PO2, 2- or 4-pyrimidyl, 2-pyridyl, 2- or 4-imidazolyl, 2-benzimidazolyl or certain other rings which may be substituted; X represents CRX-1RX-2 (RX-1 and RX-2 are H, C1-C4 alkyl, C2-C4 alkenyl or alkynyl) or together with R6 forms a 4-7-membered ring, which can include up to 2 heteroatoms, up to two double bonds and be substituted; Y represents a bond, CO, SO, SO2, O, S, CRY-1RY-2 or NRY-3, where RY-1, RY-2 or RY-3 are a bond, H, (un)substituted C1-C4 alkyl, C2-C4 alkenyl or alkynyl] and their pharmaceutically acceptable salts were prepared for the treatment of inflammatory diseases. Thus, 2-MeC6H4NHCONH-p-C6H4CH2CO-L-Leu-NHC6H4CO2H-m was prepared and showed IC50 ≤ 0.5 μM in the Jurkat VCAM-1 assay. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Product Details of 64987-16-2

The Article related to cyclic carboxylic acid peptide preparation integrin antagonist inflammation inhibitor, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Product Details of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 21, 2021, Wang, Chunmiao; Gallagher, Daniel L.; Dietrich, Andrea M.; Su, Ming; Wang, Qi; Guo, Qingyuan; Zhang, Junzhi; An, Wei; Yu, Jianwei; Yang, Min published an article.Quality Control of 2-Acetylthiazole The title of the article was Data Analytics Determines Co-occurrence of Odorants in Raw Water and Evaluates Drinking Water Treatment Removal Strategies. And the article contained the following:

A complex dataset with 140 sampling events was generated using triple quadrupole gas chromatog.-mass spectrometer to track the occurrence of 95 odorants in raw and finished water from 98 drinking water treatment plants in 31 cities across China. Data anal. identified more than 70 odorants with concentrations ranging from not detected to thousands of ng/L. In raw water, Pearson correlation anal. determined that thioethers, non-oxygen benzene-containing compounds, and pyrazines were classes of chems. that co-occurred, and geosmin and p(m)-cresol, as well as cyclohexanone and benzaldehyde, also co-occurred, indicating similar natural or industrial sources. Based on classification and regression tree anal., total dissolved organic carbon and geog. location were identified as major factors affecting the occurrence of thioethers. Indoles, phenols, and thioethers were well-removed through conventional and advanced treatment processes, while some aldehydes could be generated. For other odorants, higher removal was achieved by ozonation-biol. activated carbon (39.3%) compared to the conventional treatment process (14.5%). To our knowledge, this is the first study to systematically identify the major odorants in raw water and determine suitable treatment strategies to control their occurrence by applying data analytics and statistical methods to the complex dataset. It will provide informative reference for odor control and water quality management in drinking water industry. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Quality Control of 2-Acetylthiazole

The Article related to odorant drinking water treatment data analytic removal, co-occurrence, data mining, drinking water, odorants, removal efficiency, statistics, Water: Water Purification (Including Treatment For Industrial Uses) and other aspects.Quality Control of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 31, 2013, Lacriola, Christopher J.; Falk, Shaun P.; Weisblum, Bernard published an article.Computed Properties of 92-36-4 The title of the article was Screen for agents that induce autolysis in Bacillus subtilis. And the article contained the following:

The growing prevalence of antibiotic-resistant infections underscores the need to discover new antibiotics and to use them with maximum effectiveness. In response to these needs, the authors describe a screening protocol for the discovery of autolysis-inducing agents that uses two Bacillus subtilis reporter strains, SH-536 and BAU-102. To screen chem. libraries, autolysis-inducing agents were first identified with a BAU-102-based screen and then subdivided with SH-536 into two major groups: those that induce autolysis by their direct action on the cell membrane and those that induce autolysis secondary to inhibition of cell wall synthesis. SH-536 distinguishes between the two groups of autolysis-inducing agents by synthesizing and then releasing β-galactosidase (β-Gal) in late stationary phase at a time that cells have nearly stopped growing and are therefore tolerant of cell wall synthesis inhibitors. Four hits, named compound 2, compound 3, compound 5, and compound 24, obtained previously as inducers of autolysis by screening a 10,080-compound discovery library with BAU-102, were probed with SH-536 and found to release β-Gal, indicating that their mode of action was to permeabilize the B. subtilis cell membrane. The four primary hits inhibited growth in Staphylococcus aureus, Enterococcus faecium, Bacillus subtilis, and Bacillus anthracis, with MICs in the 12.5- to 25-μg/mL (20 to 60 μM) range. The four primary hits were further used to probe B. subtilis, and their action was partially characterized with respect to the dependence of induced autolysis on specific autolysins. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Computed Properties of 92-36-4

The Article related to agent autolysis bacillus, Microbial, Algal, and Fungal Biochemistry: Antimicrobial Sensitivity and other aspects.Computed Properties of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 12, 2017, Liu, Denggui; Yang, Kunyu; Zhou, Wei; Chen, Hao; Zeng, Qingdong published a patent.Application In Synthesis of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate The title of the patent was Method for preparing anticancer drug intermediate. And the patent contained the following:

The title anticancer drug intermediate is a compound shown in formula IIIa or IIIb. The title method comprises the steps of: conducting halogenation on 2-acetyl-4-formate thiazole compound, and reacting with tri-Ph phosphine, tri-Me phosphite, or tri-Et phosphite. The inventive compound can be applied in preparing a compound shown in formula I via conducting Wittig or Wittig-Horner reaction with isobutyraldehyde. The preparing process has the advantages of low raw material costs, mild reaction conditions, little pollution, and easy industrialization. The experimental process involved the reaction of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate(cas: 944559-46-0).Application In Synthesis of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate

The Article related to thiazole containing phosponate preparation anticancer drug intermediate, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Application In Synthesis of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Koppireddi, Satish; Avula, Sreenivas; Tiwari, Ashok K.; Ali, Amtul Z.; Yadla, Rambabu published an article in 2014, the title of the article was α-glucosidase inhibitory activity of 4-aryl-N-(2,4-thiazolidinedione-5-acetyl)-1,3-thiazol-2-amines.Application of 31699-14-6 And the article contains the following content:

A series of N-(4-aryl-1,3-thiazol-2-yl)-2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamides 3a-k and N-(1,3-benzothiazol-2-yl)-2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamides 3l-n are synthesized and evaluated for their α-glucosidase inhibitory activity. N-[4-(m-Chlorophenyl)-1,3-thiazol-2yl]-2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamide (3g) and N-[4-(o-fluorophenyl)-1,3-thiazol-2-yl]-2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamide (3j) have shown very good inhibition. The remaining compounds have exhibited moderate to good activity ranging from 37-63 % of α-glucosidase enzyme inhibition. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Application of 31699-14-6

The Article related to alpha glucosidase enzyme inhibition acetamide, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Application of 31699-14-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica