Month: November 2022

On January 18, 2007, Lau, Jesper; Murray, Anthony; Vedsoe, Per; Kristiansen, Marit; Jeppesen, Lone published a patent.Category: thiazole The title of the patent was Preparation of cyclohexyl thiazolyl ureas as glucokinase activators. And the patent contained the following:

Title compounds represented by the formula R1R2NCONHA [wherein R1 = (cycloalkyl)alkyl, cycloalkyl, heterocyclyl, etc.; R2 = (cyclo)alkyl, cycloalkenyl, heterocyclyl, etc.; A = (un)substituted heteroaryl; and pharmaceutically acceptable salts, optical isomers or tautomers thereof] were prepared as glucokinase activators. For example, reductive condensation of phenethylamine with cyclohexanone, followed by coupling reaction with Et (2-aminothiazol-5-ylsulfanyl)acetate in the presence of 1,1′-carbonyldiimidazole and hydrolysis, gave I. The glucose sensitivity of the title compounds are measured at a compound concentration of 10 μM and at glucose concentrations of 5 and 15 mM. The title compounds are useful as activators of glucokinase for the treatment of various diseases, e.g. for the treatment of type 2 diabetes (no data). The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Category: thiazole

The Article related to cyclohexyl thiazolyl urea preparation glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 18, 2007, Murray, Anthony; Lau, Jesper; Vedsoe, Per; Kristiansen, Marit; Jeppesen, Lone published a patent.Related Products of 859522-19-3 The title of the patent was Preparation of dicycloalkyl thiazolyl ureas as glucokinase activators. And the patent contained the following:

Title compounds represented by the formula R1R2NCONHA [wherein R1 = (un)substituted cyclohexyl; R2 = cyclohexyl; A = (un)substituted thiazolyl; and pharmaceutically acceptable salts, optical isomers or tautomers thereof] were prepared as glucokinase activators. For example, reaction of 2-aminothiazole with dicyclopentylamine and carbonyldiimidazole gave I. The glucose sensitivity of the title compounds are measured at a compound concentration of 10 μM and at glucose concentrations of 5 and 15 mM. The title compounds are useful as activators of glucokinase for the treatment of diabetes (no data). The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Related Products of 859522-19-3

The Article related to dicycloalkyl thiazolyl urea preparation glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 859522-19-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 1, 2009, Murray, Anthony; Lau, Jesper; Vedso, Per; Kristiansen, Marit; Jeppesen, Lone published a patent.SDS of cas: 859522-19-3 The title of the patent was Preparation of dicycloalkyl thiazolyl ureas as glucokinase activators. And the patent contained the following:

Title compounds represented by the formula R1R2NCONHA [wherein R1 = (un)substituted cyclohexyl; R2 = cyclohexyl; A = (un)substituted thiazolyl; and pharmaceutically acceptable salts, optical isomers or tautomers thereof] were prepared as glucokinase activators. For example, reaction of 2-aminothiazole with dicyclopentylamine and carbonyldiimidazole gave I. The glucose sensitivity of the title compounds are measured at a compound concentration of 10 μM and at glucose concentrations of 5 and 15 mM. The title compounds are useful as activators of glucokinase for the treatment of various diseases such as diabetes (no data). The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).SDS of cas: 859522-19-3

The Article related to dicycloalkyl thiazolyl urea preparation glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.SDS of cas: 859522-19-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 26, 2021, Sadgar, Amid L.; Deore, Tushar S.; Hase, Dattatraya V.; Jayaram, Radha V. published an article.Electric Literature of 2010-06-2 The title of the article was Graphene Oxide Pickering Emulsion – A Novel Reaction Medium for the Synthesis of 2-Aminothiazole. And the article contained the following:

In the present study, a novel protocol for the synthesis of 2-aminothiazoles was developed using a graphene oxide (GO) stabilized pickering emulsion system. GO was prepared by the modified Hummer’s method and characterized with XRD, FTIR, UV-Visible spectroscopy, TGA and DLS techniques. The size of the o/w emulsion droplets stabilized by GO were determined using a polarized optical microscope. The emulsion system was used for the synthesis of 2-aminothiazole by Hantzsch reaction. The Reactions were carried out at room temperature and under static condition, without stirring. The application of the reaction system were extended to substituted phenacyl bromides and about 93% of the corresponding 2-aminothiazole derivative was obtained in 3 h. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to graphene oxide catalyst preparation, aminothiazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 30, 2007, Zheng, Ming-Qiang; Yin, Duan-Zhi; Shen, Yu-Mei; Li, Gu-Cai published an article.Related Products of 92-36-4 The title of the article was Synthesis of 2-(4-aminophenyl)benzothiazole derivatives and determination of their activity as PET tracers for human brain β-amyloid peptides. And the article contained the following:

A series of novel 2-(4-aminophenyl)-6-substituted benzothiazole derivatives were prepared and evaluated as potential β-amyloid PET (positron emission tomog.) tracers. Were prepared from proper 2-amino-6-substituted benzothiazole derivatives through basic hydrolysis, intermol. cycloaddition and N/O-alkylation reactions. Their structures were confirmed by IR, 1H NMR, EI/ESI-MS, HRMS spectra and elemental anal. The sequence of binding affinity of some compounds with human brain homogenate was analyzed. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Related Products of 92-36-4

The Article related to benzothiazolyl benzenamine preparation pet tracer brain amyloid, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 30, 2020, Ikram, Sadaf; Dsoke, Sonia; Sarapulova, Angelina; Mueller, Marcus; Rana, Usman Ali; Siddiqi, Humaira M. published an article.Electric Literature of 2010-06-2 The title of the article was Investigation of N and S Co-doped porous carbon for sodium-ion battery, synthesized by using ammonium sulphate for simultaneous activation and heteroatom doping. And the article contained the following:

In the present work, nitrogen and sulfur co-doped porous carbon materials are obtained by using ammonium sulfate as a template. The multi-role of ammonium sulfate as an activating agent and as nitrogen and sulfur dopant is investigated. The resulting porous carbon material achieved high doping level (9.3 at% for nitrogen and 3.5 at% for sulfur) and increased interlayer spacing from 0.35 to 0.38 nm which improves the storage kinetics of Na+-ions inside the carbon lattice. The synthesized materials, when used as neg. electrodes for sodium-ion battery, provide promising electrochem. performance with a reversible storage capacity of 439 mAh g-1 at a c.d. of 10 mA g-1. The storage capacity of ~100 mAh g-1 with capacity retention of 62% retained after 200 cycles at 220 mA g-1. This work presents the multifunctional roles of ammonium sulfate in achieving the nitrogen and sulfur co-doped porous carbon materials. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to nitrogen sulfur porous carbon ammonium sulfate sodium ion battery, Electrochemical, Radiational, and Thermal Energy Technology: Energy Sources and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 11, 2009, Zhang, Xuebo; Yin, Peng; Liu, Gang; Xu, Lichen published a patent.Application of 64987-16-2 The title of the patent was Process for preparation of 2-[2-[[(phenylmethoxy)carbonyl]amino]thiazol-4-yl]acetic acid esters. And the patent contained the following:

The method comprises allowing to react alc. with benzyl chloroformate and base in the presence of 4-dimethylaminopyridine as catalyst at -10-0°C for 1-2 h, heating to 0-15°C, allowing to react for 4-10 h, filtrating, adding 2-(2-amino-thiazol-4-yl)acetic acid ester, further reacting for 12-24 h to obtain 2-[2-[[(phenylmethoxy)carbonyl]amino]thiazol-4-yl]acetic acid ester. The alc. is methanol, ethanol, isopropanol, n-propanol, n-butanol, isobutanol and/or tert-butanol. The base is triethylamine, pyridine and/or sodium carbonate. The inventive method has advantages of short reaction route, low cost, simple operation, less three waste and suitability for industrial production The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application of 64987-16-2

The Article related to phenylmethoxycarbonylamino thiazolyl acetic acid ester preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Application of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 5, 2019, there was a patent about acute b-cell leukemia.Electric Literature of 64987-16-2 The title of the patent was Preparation of substituted sulfonamidothiazoles as CTRS1 inhibitors. And the patent contained the following:

The invention relates to compounds of formula I (wherein R1 is (un)substituted C1-5 alkyl and C0-2 alkyleneC3-5 cycloalkyl; R3 is H, halo, CH3, etc.; R4 and R5 are independently H, halo, C1-6 alkyl, etc.; R6 is H and C1-3 alkyl, etc.; Ar1 is 6-membered aryl and heteroaryl; Ar2 is 6-membered aryl and heteroaryl; R10 is H, halo, C1-3 alkyl, etc.; R11 is H, F, Cl, Me, etc.; R12 is H, halo, C1-4 alkyl, etc.; R13 is H, halo, Me and OMe;) and salts, solvates thereof and derivatives thereof, their preparation and use as CTR synthase 1 inhibitors for the treatment of disorders associated with cell proliferation. Example compound II was prepared by cross-coupling of N-(4-bromophenyl)-2-(2-(cyclopropanesulfonamido)thiazol-4-yl)-2-methylpropanamide with pyrimidin-5-ylboronic acid. The invention compounds were evaluated for their CTRS1 inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of ≤ 1μM. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Electric Literature of 64987-16-2

The Article related to sulfonamidothiazole preparation ctrs1 inhibitor treatment cell proliferation, acute b-cell leukemia and other aspects.Electric Literature of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 6, 2019, Quddus, Abdul; Novak, Andrew; Cousin, David; Chatzopoulou, Elli; Blackham, Emma; Jones, Geraint; Thomas, Jennifer; Wrigglesworth, Joseph; Duffy, Lorna; Birch, Louise; George, Pascal; Ahmed, Saleh published a patent.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of substituted sulfonamidothiazoles as CTRS1 inhibitors. And the patent contained the following:

The invention relates to compounds of formula I (wherein R1 is (un)substituted C1-5 alkyl and C0-2 alkyleneC3-5 cycloalkyl; R3 is H, halo, CH3, etc.; R4 and R5 are independently H, halo, C1-6 alkyl, etc.; R6 is H and C1-3 alkyl, etc.; Ar1 is 6-membered aryl and heteroaryl; Ar2 is 6-membered aryl and heteroaryl; R10 is H, halo, C1-3 alkyl, etc.; R11 is H, F, Cl, Me, etc.; R12 is H, halo, C1-4 alkyl, etc.; R13 is H, halo, Me and OMe;) and salts, solvates thereof and derivatives thereof, their preparation and use as CTR synthase 1 inhibitors for the treatment of disorders associated with cell proliferation. Example compound II was prepared by cross-coupling of N-(4-bromophenyl)-2-(2-(cyclopropanesulfonamido)thiazol-4-yl)-2-methylpropanamide with pyrimidin-5-ylboronic acid. The invention compounds were evaluated for their CTRS1 inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of ≤ 1μM. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to sulfonamidothiazole preparation ctrs1 inhibitor treatment cell proliferation and other aspects.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 8, 2004, Polisetti, Dharma Rao; Kodra, Janos Tibor; Lau, Jesper; Bloch, Paw; Valcarce-Lopez, Maria Carmen; Blume, Niels; Guzel, Mustafa; Santhosh, Kalpathy Chidambareswaran; Mjalli, Adnan M. M.; Andrews, Robert Carl; Subramanian, Govindan; Ankersen, Michael; Vedso, Per; Murray, Anthony; Jeppesen, Lone published a patent.Reference of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of thiazolyl aryl ureas as activators of glucokinase. And the patent contained the following:

The title compounds [I; A1 = arylene, heteroarylene, fused cycloalkylarylene, etc.; L1 = a bond, O, S, SO, etc.; G1 = alkyl, cycloalkyl, cycloalkylalkylene, etc.; L2 = a bond, alkylene, alkenylene, etc.; L3 = CO, COCO, COCH2CO, SO2; R1 = alkyl, alkenyl, alkynyl, etc.; G2 = heteroaryl, fused heterocyclylheteroaryl, cycloalkylheteroaryl, etc.] which are activators of glucokinase and may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial (no data), were prepared and formulated. Thus, reacting 2-phenoxyaniline with 2-aminothiazole and 1,1′-carbonyldiimidazole afforded 95% the urea II. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Reference of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to thiazolyl aryl urea preparation formulation glucokinase activator antidiabetic and other aspects.Reference of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica