de Andrade, Vitor S. C. et al. published their research in Tetrahedron Letters in 2020 |CAS: 2010-06-2

The Article related to aryl aminothiazole preparation tribromoisocyanuric acid promoter, styrene thiourea tandem reaction, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Formula: C9H8N2S

On July 23, 2020, de Andrade, Vitor S. C.; de Mattos, Marcio C. S. published an article.Formula: C9H8N2S The title of the article was One-pot synthesis of 4-aryl-2-aminothiazoles from styrenes and thioureas promoted by tribromoisocyanuric acid. And the article contained the following:

A simple and efficient one-pot protocol has been developed for the conversion of styrenes into 4-aryl-2-aminothiazoles using readily available starting materials. Tribromoisocyanuric acid was successfully used for the co-bromination and oxidation of styrenes to give phenacyl bromides, which in the presence of thioureas produced the corresponding 4-aryl-2-aminothiazoles in 48-70% yield. The protocol involves three reactions in one process: a tandem (formation of phenacyl bromides from styrenes) followed by a telescoped (conversion to thiazole) reaction. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Formula: C9H8N2S

The Article related to aryl aminothiazole preparation tribromoisocyanuric acid promoter, styrene thiourea tandem reaction, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Formula: C9H8N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Fang, Weizheng et al. published their patent in 2010 |CAS: 64987-16-2

The Article related to ceftibuten side chain preparation aminothiazolylacetic acid hydroxymethylation wittig esterification, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.COA of Formula: C6H8N2O2S

On September 8, 2010, Fang, Weizheng; Zhang, Hongjian; Qian, Dongbo published a patent.COA of Formula: C6H8N2O2S The title of the patent was Method for synthesis of Ceftibuten side chain from 2-aminothiazolylacetic acid. And the patent contained the following:

A process for preparation of Ceftibuten side chain I from 2-aminothiazolylacetic acid via carboxylic group protection, amino protection, hydroxymethylation, Wittig reaction, and mono esterification in five steps (detail procedure given) is disclosed. The process has advantages of no employment of expensive Me 3-methoxyacrylate, lower cost, reduced pollution to environment, simple process, good controllability, high and stable yield, suitability for industrial production The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).COA of Formula: C6H8N2O2S

The Article related to ceftibuten side chain preparation aminothiazolylacetic acid hydroxymethylation wittig esterification, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.COA of Formula: C6H8N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Poola, Sreelakshmi et al. published their research in Phosphorus, Sulfur and Silicon and the Related Elements in 2020 |CAS: 2010-06-2

The Article related to thiazolyl aminomethylene bisphosphonate preparation mol docking antioxidant antibacterial antifungal, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: 4-Phenylthiazol-2-amine

Poola, Sreelakshmi; Gundluru, Mohan; Nadiveedhi, Maheshwara Reddy; Saddala, Madhu Sudhana; P. T. S. R. K., Prasada Rao; Cirandur, Suresh Reddy published an article in 2020, the title of the article was Nano silver particles catalyzed synthesis, molecular docking and bioactivity of α-thiazolyl aminomethylene bisphosphonates.Recommanded Product: 4-Phenylthiazol-2-amine And the article contains the following content:

A new series of α-thiazolyl aminomethylene bisphosphonates I (R1 = H, OCH3, F, Br; R2 = OMe, OEt, OBu, OPh)were synthesized by a three component reaction of 4-aryl substituted thiazol-2-amine with different dialkyl/aryl phosphites and tri-Et orthoformate in the presence of Ag NPs (nano particles) as a catalyst under solvent free conditions. The target compounds were screened for their in vitro antioxidant, antibacterial and antifungal activity. Mol. docking studies were also performed. The results revealed that among the synthesized compounds I (R1 = OCH3, F, Br; R2 = Me) showed remarkably higher antioxidant activity by DPPH and H2O2 than the standard ascorbic acid. Compounds I (R1 = H, OCH3, F; R2 = Me) showed good antibacterial activity and also showed rather higher antifungal activity than the standard flucanozole. Computational docking methods have been used to predict how several aminomethylene bisphosphonate derivatives compete against the inhibitor BPH-1330 at the crystal enzyme structure of the 4H3A protein active site and how substituents influence their binding ability. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 4-Phenylthiazol-2-amine

The Article related to thiazolyl aminomethylene bisphosphonate preparation mol docking antioxidant antibacterial antifungal, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Liang, Xiao-Ping et al. published their research in Tetrahedron Letters in 2022 |CAS: 2010-06-2

The Article related to amino arylthiazole preparation green chem, aryl methyl ketone sulfur cyanamide three component cascade, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Reference of 4-Phenylthiazol-2-amine

On June 22, 2022, Liang, Xiao-Ping; Luo, Min; Kang, Li; Tang, Long-Xing; Liang, Qing; Liu, Yuan-Lin; Yang, Zi; Zhang, Chun-Tao; Peng, Cai-Yun; Fu, Rong-Geng published an article.Reference of 4-Phenylthiazol-2-amine The title of the article was Facile one-pot three-component strategy for the synthesis of 2-amino-4-arylthiazoles via elemental sulfur source. And the article contained the following:

A novel and facile metal-free method for the green synthesis of 2-amino-4-arylthiazole derivatives I (Ar = 3-nitrophenyl, 2-naphthyl, pyridin-4-yl, etc.) through the three-component cascade reaction of aromatic Me ketones ArC(O)Me, elemental sulfur and cyanamide is reported. One C-N bond and two C-S bonds were formed in one-pot protocol without using catalysts. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Reference of 4-Phenylthiazol-2-amine

The Article related to amino arylthiazole preparation green chem, aryl methyl ketone sulfur cyanamide three component cascade, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Reference of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Liang, Xiao-Ping et al. published their research in Tetrahedron Letters in 2022 |CAS: 24295-03-2

The Article related to amino arylthiazole preparation green chem, aryl methyl ketone sulfur cyanamide three component cascade, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Category: thiazole

On June 22, 2022, Liang, Xiao-Ping; Luo, Min; Kang, Li; Tang, Long-Xing; Liang, Qing; Liu, Yuan-Lin; Yang, Zi; Zhang, Chun-Tao; Peng, Cai-Yun; Fu, Rong-Geng published an article.Category: thiazole The title of the article was Facile one-pot three-component strategy for the synthesis of 2-amino-4-arylthiazoles via elemental sulfur source. And the article contained the following:

A novel and facile metal-free method for the green synthesis of 2-amino-4-arylthiazole derivatives I (Ar = 3-nitrophenyl, 2-naphthyl, pyridin-4-yl, etc.) through the three-component cascade reaction of aromatic Me ketones ArC(O)Me, elemental sulfur and cyanamide is reported. One C-N bond and two C-S bonds were formed in one-pot protocol without using catalysts. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Category: thiazole

The Article related to amino arylthiazole preparation green chem, aryl methyl ketone sulfur cyanamide three component cascade, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Safari, Javad et al. published their research in Polycyclic Aromatic Compounds in 2020 |CAS: 2010-06-2

The Article related to aminothiazole preparation green chem, methylcarbonyl thiourea cyclocondensation asparagine organocatalyst, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Synthetic Route of 2010-06-2

Safari, Javad; Shokrani, Zahra; Zarnegar, Zohre published an article in 2020, the title of the article was Asparagine as a Green Organocatalyst for the Synthesis of 2-Aminothiazoles.Synthetic Route of 2010-06-2 And the article contains the following content:

In this research, an efficient method for the one-pot synthesis of 2-aminothiazoles via reaction of thiourea with methylcarbonyls in the presence of iodine as an oxidant reagent has been developed using asparagine as a green organocatalyst at 80° in DMSO solvent. Advantages of this efficient method include greener and cleaner conditions, easy isolation of products, higher purity and excellent yield of products, and convenient manipulation. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Synthetic Route of 2010-06-2

The Article related to aminothiazole preparation green chem, methylcarbonyl thiourea cyclocondensation asparagine organocatalyst, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Synthetic Route of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Li, Pei et al. published their research in Journal of Environmental Chemical Engineering in 2022 |CAS: 2010-06-2

The Article related to ketone thiourea ammonium iodide tandem electrooxidative cyclization green chem, aminothiazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Synthetic Route of 2010-06-2

On June 30, 2022, Li, Pei; Yang, Shang-Feng; Fang, Zi-Lin; Cui, Hao-Ran; Liang, Sen; Tian, Hong-Yu; Sun, Bao-Guo; Zeng, Cheng-Chu published an article.Synthetic Route of 2010-06-2 The title of the article was An efficient one-pot synthesis of 2-aminothiazoles via electrochemically oxidative α-C-H functionalization of ketones with thioureas. And the article contained the following:

An efficient one-pot electrochem. protocol for the synthesis of 2-aminothiazoles was described from electrolysis of ketones with thioureas mediated by iodide ion. The electrochem. synthesis was conducted in an undivided cell equipped with graphite plates electrodes under constant current conditions. A diversity of aromatic and aliphatic ketones were suitable for the reaction, yielding the corresponding 2-aminothiazoles in satisfactory yields. Mechanistically, the in-situ generated α-iodoketone was proposed to be a key active species. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Synthetic Route of 2010-06-2

The Article related to ketone thiourea ammonium iodide tandem electrooxidative cyclization green chem, aminothiazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Synthetic Route of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shibasaki, Kaho et al. published their research in European Journal of Organic Chemistry in 2019 |CAS: 31699-14-6

The Article related to aminoarylthiazole synthesis alkylarene nbs thiourea, arylthiazole synthesis alkylarene nbs arenethioamide, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Application In Synthesis of 2-Amino-4-(4-iodophenyl)thiazole

Shibasaki, Kaho; Togo, Hideo published an article in 2019, the title of the article was 2-Amino-4-arylthiazoles through One-Pot Transformation of Alkylarenes with NBS and Thioureas.Application In Synthesis of 2-Amino-4-(4-iodophenyl)thiazole And the article contains the following content:

Treatment of alkylarenes with N-bromosuccinimide in a mixture of Et acetate and water at 60 °C, a mixture of acetonitrile and water at 80 °C, or a mixture of di-Et carbonate and water under irradiation with a tungsten lamp, followed by a reaction with thioureas or arenethioamides provided the corresponding 2-amino-4-arylthiazoles or 2,4-diarylthiazoles in good to moderate yields, resp., in one pot [e.g., ethylbenzene + thiourea → 2-amino-4-phenylthiazole (84%)]. The present reaction is an efficient one-pot transformation method of alkylarenes into 2-amino-4-arylthiazoles and 2,4-diarylthiazoles directly under mild and transition-metal-free conditions. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Application In Synthesis of 2-Amino-4-(4-iodophenyl)thiazole

The Article related to aminoarylthiazole synthesis alkylarene nbs thiourea, arylthiazole synthesis alkylarene nbs arenethioamide, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Application In Synthesis of 2-Amino-4-(4-iodophenyl)thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shibasaki, Kaho et al. published their research in European Journal of Organic Chemistry in 2019 |CAS: 2010-06-2

The Article related to aminoarylthiazole synthesis alkylarene nbs thiourea, arylthiazole synthesis alkylarene nbs arenethioamide, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Computed Properties of 2010-06-2

Shibasaki, Kaho; Togo, Hideo published an article in 2019, the title of the article was 2-Amino-4-arylthiazoles through One-Pot Transformation of Alkylarenes with NBS and Thioureas.Computed Properties of 2010-06-2 And the article contains the following content:

Treatment of alkylarenes with N-bromosuccinimide in a mixture of Et acetate and water at 60 °C, a mixture of acetonitrile and water at 80 °C, or a mixture of di-Et carbonate and water under irradiation with a tungsten lamp, followed by a reaction with thioureas or arenethioamides provided the corresponding 2-amino-4-arylthiazoles or 2,4-diarylthiazoles in good to moderate yields, resp., in one pot [e.g., ethylbenzene + thiourea → 2-amino-4-phenylthiazole (84%)]. The present reaction is an efficient one-pot transformation method of alkylarenes into 2-amino-4-arylthiazoles and 2,4-diarylthiazoles directly under mild and transition-metal-free conditions. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Computed Properties of 2010-06-2

The Article related to aminoarylthiazole synthesis alkylarene nbs thiourea, arylthiazole synthesis alkylarene nbs arenethioamide, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Computed Properties of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Gorji, Samareh et al. published their research in Journal of Molecular Structure in 2021 |CAS: 2010-06-2

The Article related to aryl alkyne thiourea sodium alginate catalyst heterocyclization, amino arylthiazole preparation green chem, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 2010-06-2

On May 5, 2021, Gorji, Samareh; Ghorbani-Vaghei, Ramin; Alavinia, Sedigheh published an article.Related Products of 2010-06-2 The title of the article was Sodium alginate: Biopolymeric catalyst for the synthesis of 2-amino-4-arylthiazole derivatives in aqueous medium. And the article contained the following:

An efficient and recoverable bifunctional heterogeneous organocatalyst for the synthesis of 2-amino-4-arylthiazole derivatives was carried out by the reaction of substituted Ph acetylene and thiourea in an eco-friendly condition in the presence of TBBDA. Mild reaction conditions, simple reaction procedure, easy purification, high yields of products, eco-friendly catalyst usage and convenient reusability were the highlighted points of this protocol. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Related Products of 2010-06-2

The Article related to aryl alkyne thiourea sodium alginate catalyst heterocyclization, amino arylthiazole preparation green chem, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica