Wang, Jie’s team published research in Hecheng Huaxue in 21 | CAS: 5053-24-7

Hecheng Huaxue published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C12H19BrS, Quality Control of 5053-24-7.

Wang, Jie published the artcileProcess improvement on the synthesis of 3-mercapto-1-(1, 3-thiazolin-2-yl) azetidine hydrochloride, Quality Control of 5053-24-7, the publication is Hecheng Huaxue (2013), 21(3), 367-369, database is CAplus.

A key intermediate of Tebipenem pivoxil, 3-mercapto-1-(1, 3-thiazolin-2-yl) azetidine hydrochloride, was synthesized from benzylamine by N-alkylation, cyclization, catalytic hydrogenation, N-protection, mesylation, SN2 substitution, hydrolysis, and condensation. The overall yield was 40%. The structure was confirmed by 1H NMR, IR and MS.

Hecheng Huaxue published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C12H19BrS, Quality Control of 5053-24-7.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica