Day: December 6, 2022

Lei, Yingjie published the artcileSynthesis of 2-(4-aminophenyl)benzothiazoles using MF resin supported H⁺ under solvent free conditions, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Russian Journal of General Chemistry (2015), 85(3), 679-682, database is CAplus.

A simple and convenient approach to 2-(4-aminophenyl)benzothiazole derivatives by condensation of o-aminothiophenol with (un)substituted p-aminobenzoic acid under the action of melamine formaldehyde resin (MFR) supported sulfuric acid under microwave irradiation (MW) and solvent-free conditions has been developed. Structures of the corresponding products were elucidated by IR, ¹H NMR spectra, and elemental anal. The resin could be easily recovered and reused for subsequent reactions.

Russian Journal of General Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Bungthong, Chuleeporn published the artcileAmino acid profile and biological properties of silk cocoon as affected by water and enzyme extraction, Related Products of thiazole, the publication is Molecules (2021), 26(11), 3455, database is CAplus and MEDLINE.

We compared the efficacy for protein extraction of water vs. enzymic extraction The amino-acid composition, inhibitory activity against enzymes α-amylase and a-glucosidase, and anti-glycation activities of silk protein extract (SPE) were determined We used water extraction (100°C, six hours) and protease-enzymic extraction The microstructure of silk fibers was obviously different after extraction The results showed that enzymic extraction gave the greater values of protein content, amino acids, total phenolic content (TPC), and total flavonoid content (TFC), as well as all biol. activities parameters tested, but it also provided a more bitter taste in the extract-contributing amino acids of 51% (arginine, phenylalanine, histidine, valine, tryptophan, isoleucine, and leucine) and less sweet and umami taste contributing amino acids than did water extraction, which could be more suitable to be used as concentrated nutraceuticals.

Molecules published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Zheng, Jun published the artcileRhodium-Catalyzed Chemo-, Regio-, and Enantioselective Allylation of 2-Aminothiazoles with Terminal Allenes, Recommanded Product: 6-Chlorobenzothiazol-2-ylamine, the publication is European Journal of Organic Chemistry (2019), 2019(31-32), 5180-5182, database is CAplus.

A rhodium-catalyzed chemo-, regio- and enantioselective intermol. coupling reaction of 2-aminobenzothiazoles with terminal allenes is reported. The new reaction displays a wide substrate scope for both reaction partners to deliver the allylation products in good yields, with excellent regio- and enantioselectivity. This novel methodol. was further applied in an efficient synthesis of chiral isothiourea.

European Journal of Organic Chemistry published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C15H24S, Recommanded Product: 6-Chlorobenzothiazol-2-ylamine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Gil, D. L. published the artcileStructure-activity relationships of 1,2,3-benzothiadiazole insecticide synergists as inhibitors of microsomal oxidation, HPLC of Formula: 1753-29-3, the publication is Pesticide Biochemistry and Physiology (1977), 7(2), 183-93, database is CAplus.

The activities of 47 substituted 1,2,3-benzothiadiazoles (I) as inhibitors of microsomal epoxidation and/or hydroxylation in enzyme preparations from rat liver or armyworm (Spodoptera eridania) gut have been evaluated. Many were found to be effective inhibitors of microsomal oxidation, the most active being the 6-butyl [60474-26-2] and 6-propoxy [63226-45-9] derivatives with I50 values of 4.9 × 10-7 and 7.0 × 10-7 M, resp., for the epoxidation reaction. Regression anal. have established that activity of the 5-, 6-, and 5,6-substituted compounds can be satisfactorily described in equations in terms of π2, π, and σ whereas that of the 4-substituted derivatives depends on π and the steric parameter Es.

Pesticide Biochemistry and Physiology published new progress about 1753-29-3. 1753-29-3 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Amine, name is Benzo[d][1,2,3]thiadiazol-5-amine, and the molecular formula is C6H5N3S, HPLC of Formula: 1753-29-3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Gil, D. L. published the artcileStructure-activity relations of 1,2,3-benzothiadiazoles as synergists for carbaryl against the house fly (Musca domestica), Name: Benzo[d][1,2,3]thiadiazol-5-amine, the publication is Pesticide Biochemistry and Physiology (1976), 6(4), 338-49, database is CAplus.

1,2,3-Benzothiadiazoles (I, R, R1, R2, R3 = H, halogen, NH2, OH, CN, or alkyl) and related compounds were evaluated as carbaryl [63-25-2] synergists against the housefly (M. domestica). Many of these were excellent synergists, the most active being those containing various combinations of halogen, alkyl, or alkoxy substituents in the 5- and/or 6-positions of the ring. Regression anal. on the data from 14 compounds for which substituents constants were available established that synergistic activity can be satisfactorily described by equations in terms of the hydrophobic bonding constant (π) and the homolytic free radical constant (σâ€?. The results with compounds related to the 1,2,3-benzothiadiazoles suggest that synergistic activity is associated primarily with the diazosulfide moiety.

Pesticide Biochemistry and Physiology published new progress about 1753-29-3. 1753-29-3 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Amine, name is Benzo[d][1,2,3]thiadiazol-5-amine, and the molecular formula is C6H5N3S, Name: Benzo[d][1,2,3]thiadiazol-5-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Rutkauskaite, Andzelika published the artcileSupramolecular self-associating amphiphiles: determination of molecular self-association properties and calculation of critical micelle concentration using a high-throughput, optical density based methodology, SDS of cas: 92-36-4, the publication is Organic & Biomolecular Chemistry (2022), 20(30), 5999-6006, database is CAplus and MEDLINE.

Supramol. self-associating amphiphiles are a class of amphiphilic salt, the anionic component of which is ′frustratedâ€?in nature, meaning multiple hydrogen bonding modes can be accessed simultaneously. Here we derive critical micelle concentration values for four supramol. self-associating amphiphiles using the standard pendant drop approach and present a new high-throughput, optical d. measurement based methodol., to enable the estimation of critical micelle concentrations over multiple temperatures In addition, we characterize the low-level hydrogen bonded self-association events in the solid state, through single crystal X-ray diffraction, and in polar organic DMSO-d₆ solutions using a combination of ¹H NMR techniques. Moving into aqueous ethanol solutions (EtOH/H₂O or EtOH/D₂O (1 : 19 volume/volume)), we also show these amphiphilic compounds to form higher-order self-associated species through a combination of ¹H NMR, dynamic light scattering and zeta potential studies.

Organic & Biomolecular Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, SDS of cas: 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Liang, Xinyu published the artcileThe Aryl Sulfide Synthesis via Sulfide Transfer, COA of Formula: C4H5NS2, the publication is Chemistry – A European Journal (2022), 28(35), e202200869, database is CAplus and MEDLINE.

Aryl sulfides are in great demands in drugs and materials sciences. To avoid using nucleophilic and noxious thiols, many efforts have been focused on exploring novel sulfide resources. Herein, a reductive Pd-catalyzed, Ni-mediated method to synthesize aryl sulfides via a sulfide transfer reaction is developed. The utility and scope of this reaction is exemplified by various aryl electrophiles and aryl sulfides. Mechanistic studies reveal two competing catalytic cycles of sulfide transfer and aryl transfer in this reaction, where the former one is favored over the later one because of the large energy barrier difference during the transmetalation. Moreover, two important chems. are late-stage functionalized by this method, exhibiting the potential applications in drugs and materials science.

Chemistry – A European Journal published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, COA of Formula: C4H5NS2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Liyanage, Piyumi Dinusha published the artcileL-cysteine as an irreversible inhibitor of the peroxidase-mimic catalytic activity of 2-dimensional Ni-based nanozymes, Recommanded Product: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is Nanomaterials (2021), 11(5), 1285, database is CAplus and MEDLINE.

The ability to modulate the catalytic activity of inorganic nanozymes is of high interest. In particular, understanding the interactions of inhibitor mols. with nanozymes can bring them one step closer to the natural enzymes and has thus started to attract intense interest. To date, a few reversible inhibitors of the nanozyme activity have been reported. However, there are no reports of irreversible inhibitor mols. that can permanently inhibit the activity of nanozymes. In the current work, we show the ability of L-cysteine to act as an irreversible inhibitor to permanently block the nanozyme activity of 2-dimensional (2D) NiO nanosheets. Determination of the steady state kinetic parameters allowed us to obtain mechanistic insights into the catalytic inhibition process. Further, based on the irreversible catalytic inhibition capability of L-cysteine, we demonstrate a highly specific sensor for the detection of this biol. important mol.

Nanomaterials published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Recommanded Product: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Batty, J. W. published the artcileAcetylene reactions. III. Reaction of aminobutynes with carbon disulfide, HPLC of Formula: 5053-24-7, the publication is Journal of the Chemical Society (1949), 786-9, database is CAplus.

Addition of 10 cc. CS₂ to 11.1 g. iso-PrNHCHMeCCH (I), 4 g. NaOH, and 30 cc. H₂O at 50°, with stirring for an addnl. 2 hrs., gives 58% 4-methyl-3-isopropyl-5-methylene-2-thiazolidinethione (II), MeCH.C(:CH₂).S.CS.NCHMe₂, b_0.4 130-5°, m. 43°. II results in 8-g. yield on refluxing 4 hrs. 10.6 g. I and 10 cc. CS₂ in 50 cc. EtOH. II with O₃ gives HCHO. BuNHCHMeCCH (12.5 g.) yields 87% of the 3-Bu homolog of II, b_0.5, 140-2°, n_D¹⁶ 1.5975. 3-Cyclohexyl analog of II, b_0.15 150-60°, m. 69-70°. 3-Benzyl analog, pale yellow, b_0.075 165-75°. (iso-PrNHCHMeCC)₂ (5 g.) yields 2.5 g. 1,2-bis(4-methyl-3-isopropyl-2-thiono-5-thiazolyl)ethane, [S.CS.N(CHMe₂).CMe:CCH₂]₂, m. 270° (decomposition). Solution of 2.5 g. II in cold concentrated H₂SO₄ gives 2 g. 4,5-dimethyl-3-isopropyl-2(3H)-thiazolethione (III), m. 84-6°; III results in 7.2-g. yield from 9 g. MeCHBrAc with 4.85 g. CS₂ and 7.5 g. iso-PrNH₂ in 25 cc. EtOH. 3-Bu homolog of III, pale yellow, m. 42-4°; cyclohexyl analog (IV), m. 104°; benzyl analog, m. 111°. CS₂ (19.5 g.) and 30 g. iso-PrNH₂ in 100 cc. EtOH, treated (0.5 hr.) with ClCH₂Ac, give 26 g. 4-methyl-3-isopropyl-2(3H)-thiazolethione, m. 68-9°; 13 g. 2-ClCH₂CH₂Ac gives 21 g. 10-3-ketobutyl isopropyldithiocarbamate, m. 62°; this is not cyclized by treatment with cold concentrated H₂SO₄ or on heating in EtOH. 2-Cyclohexylamino-3-butyne (20 g.), on hydrogenation in MeOH over Raney Ni, gives 15 g. N-cyclohexyl-sec-butylamine (V), b₂₅ 86-8°, n_D¹⁶ 1.4350 (HCl salt, m. 210°); 10 g. V, 9 g. MeI, and 5 g. KOH, heated 2 hrs. on the steam bath and the base in dilute HCl treated with a slight excess of saturated aqueous NaNO₂, give 4.5 g. N-cyclohexylmethyl-sec-butylamine (VI), b₂₂ 90-3° (methiodide, m. 174-6°); 3 g. IV and 20 cc. Raney Ni in 80 cc. EtOH, refluxed 4 hrs., give 0.4 g. VI. MeNHCH₂CH₂OH (5 g.) in 7 cc. CS₂, heated 3.5 hrs. at 120-40°, gives 5.8 g. 3-methyl-2-thiazolidinethione, b. 90-100 °/10^-4 mm. (bath), m. 68-9°; with MeI it yields 2-(methylmercapto) thiazoline-MeI, m. 132°. BuNHCH₂CH₂OH (5 g.) and 5 cc. CS₂, heated 3.5 hrs. at 120-40°, give 4.9 g. 3-butyl-2-thiazolidinethione, yellow, b. 90-5°/10^-4 mm. (bath), n_D^22.5 1.5970.

Journal of the Chemical Society published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, HPLC of Formula: 5053-24-7.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Zhang, Zeshuai published the artcileThree-Component One-Pot Construction of 2-Aryl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidines Using Solid Calcium Carbide as a Surrogate of Gaseous Acetylene, Application In Synthesis of 95-24-9, the publication is Organic Letters (2022), 24(29), 5491-5496, database is CAplus and MEDLINE.

A concise method for the construction of 2-aryl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidines I (R = H, Cl, OMe; R¹ = Ph, naphthalen-2-yl, thiophen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.) using solid calcium carbide instead of gaseous acetylene as an alkyne source and 2-aminobenzothiazoles II and aromatic aldehydes R¹CHO as substrates through one-pot three-component cascade reactions is described. The salient features for this protocol are the use of an inexpensive and easy-to-handle alkyne source, noble-metal-free condition, wide substrate scope and functional tolerance, satisfactory yield, and simple workup procedure.

Organic Letters published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C13H9FO2, Application In Synthesis of 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica