Day: December 6, 2022

Piechowiak, Tomasz published the artcileChanges in the activity of flavanone 3β-hydroxylase in blueberry fruit during storage in ozone-enriched atmosphere, Recommanded Product: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is Journal of the Science of Food and Agriculture (2022), 102(3), 1300-1304, database is CAplus and MEDLINE.

The present study aimed to determine whether the ozonation process affects the flavonoid biosynthesis in highbush blueberry (Vaccinum corymbosum L.) fruit. Flavanone 3β-hydroxylase (F3H) was used as a marker of the flavonoid biosynthesis pathway. The activity of F3H, the expression of gene encoding F3H and the antioxidant status in blueberries treated with ozone at a concentration of 15 ppm for 30 min, every 12 h of storage, and maintained at 4°C for 4 wk were investigated. The results showed that ozonation process increases the expression of the F3H gene after 1 wk of storage, which translates into a higher catalytic capacity of protein, as well as a higher content of flavonoids and total antioxidant potential of ozonated blueberries compared to non-ozonated fruits. The present study provides exptl. evidence indicating that ozone treatment in proposed process conditions pos. affects flavonoid metabolism in highbush blueberry fruit leading to the maintainance of the high quality of the fruit during storage.

Journal of the Science of Food and Agriculture published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Recommanded Product: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Martvon, A. published the artcileIsothiocyanates. XXXIII. Synthesis and infrared spectra of benzothiazolyl isothiocyanates, COA of Formula: C14H12N2S, the publication is Chemicke Zvesti (1973), 27(3), 387-92, database is CAplus.

Isothiocyanates I (R = H, NCS, Me; R1 = H, NCS; R2 = H; R3 = 4-Me, 4-MeO, 4-halo, 2-Cl, 3- and 4-NCS; R2 = 3-Cl, R3 = 4-NCS) (12 compounds) were prepared in 30-61% yields by treating amines I (R = H, H2N, Me; R1 = H, H2N; R2 = Cl, R3 = 4-H2N) with CSCl2.

Chemicke Zvesti published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, COA of Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Vernin, Gaston published the artcileSynthesis and physicochemical study of sulfides, sulfoxides and sulfones in the thiazole series, Recommanded Product: 2-(Methylthio)thiazole, the publication is Journal of Heterocyclic Chemistry (1978), 15(8), 1361-6, database is CAplus.

The alkylation of Δ⁴-thiazoline-2-thiones under phase transfer catalysis conditions gave the corresponding thio ethers, e.g., I, in good yields. The oxidation of 2-alkylthiazoles with m-ClC₆H₄C(O)OOH gave the corresponding sulfoxides or sulfones depending on exptl. conditions in yields of âˆ?0-90%. IR, ¹H NMR mass spectra, and chromatog. data are reported for most of the compounds studied.

Journal of Heterocyclic Chemistry published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H6N2, Recommanded Product: 2-(Methylthio)thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Mor, Satbir published the artcileConvenient and efficient synthesis of novel 11H-benzo[5,6][1,4]thiazino[3,4-a]isoindol-11-ones derived from 2-bromo-(2/3-substituted phenyl)-1H-indene-1,3(2H)-diones, Product Details of C7H5ClN2S, the publication is RSC Advances (2019), 9(23), 12784-12792, database is CAplus and MEDLINE.

An unprecedented formation of 11H-benzo[5,6][1,4]thiazino[3,4-a]isoindol-11-ones I (R¹ = 2-Me, 2-MeO, 2-F, 3-F; R² = H, Me, OMe, Cl, Br) through a one-step reaction of differently substituted 2-aminobenzenethiols 2-H₂N-5-R²C₆H₄SH and 2-bromo-(2/3-substituted phenyl)-1H-indene-1,3(2H)-diones II in freshly dried ethanol under reflux conditions has been investigated. This unique transformation probably occurs through an initial nucleophilic substitution followed by ring opening and subsequent intramol. cyclization. The structures of all the synthesized benzo[1,4]thiazino isoindolinones I were established by FTIR, ¹H NMR, ¹³C NMR, HRMS, and X-ray crystallog. anal. This approach was found to be simple and convenient and provides several advantages such as substantial atom economy, short reaction time and operational simplicity.

RSC Advances published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Product Details of C7H5ClN2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Mor, Satbir published the artcileSynthesis, Type II diabetes inhibitory activity, antimicrobial evaluation and docking studies of indeno[1,2-c]pyrazol-4(1H)-ones, HPLC of Formula: 95-24-9, the publication is Medicinal Chemistry Research (2020), 29(1), 46-62, database is CAplus and MEDLINE.

A convenient and efficient synthesis of indeno[1,2-c]pyrazol-4(1H)-ones I (R¹ = Me, i-Pr, i-butyl; R² = H, Me, Cl, etc.) by the reaction of a variety of 2-acyl-(1H)-indene-1,3(2H)-diones and 2-hydrazinylbenzo[d]thiazole/2-hydrazinyl-6-substitutedbenzo[d]thiazoles in the presence of glacial acetic acid in good yields is reported. All the synthesized indeno[1,2-c]pyrazol-4(1H)-ones I were assayed for their in vitro Type II diabetes inhibitory activity by using Acarbose as standard drug and in vitro antimicrobial activity utilizing Streptomycin and Fluconazole as reference drugs. Among the synthesized derivatives, I (R¹ = Me; R² = Br) (IC₅₀ = 6.71 μg/mL) was found to be more potent against α-glucosidase enzyme as compared with the standard Acarbose (IC₅₀ = 9.35 μg/mL) and I (R¹ = i-propyl; R² = Cl) (IC₅₀ = 11.90 μg/mL) exhibited good inhibitory activity against α-amylase enzyme as compared with the standard Acarbose (IC₅₀ = 22.87 μg/mL). Also, all the titled compounds showed good antimicrobial activity. In addition, in vitro α-glucosidase and α-amylase inhibition were supported by docking studies performed on the derivatives I (R¹ = Me, i-butyl; R² = Br) resp.

Medicinal Chemistry Research published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, HPLC of Formula: 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Nishad, Ravi K. published the artcileDesign and Synthesis of 2-Substituted Benzothiazole Derivatives as Antioxidant and Antimicrobial Agents, Computed Properties of 95-24-9, the publication is Current Bioactive Compounds (2020), 16(8), 1242-1248, database is CAplus.

An upsurge in the number of antibiotic-resistant microbial infections has warranted the discovery and development of new antibiotics. This is a matter of great concern for effective therapy for a search of novel antimicrobial agents. Literature has a number of reports of involvement of oxidative stress due to an imbalance between the generation and neutralization of free radicals in many diseases. Heterocyclic compounds have been involved in the treatment of various disorders. Benzothiazole is one such heterocyclic nucleus having benzene ring merged with the thiazole ring. Among the various substitutions possible in this nucleus, substitutions at position-2 have already been reported with potential bioactivities. Thus, different substituted compounds have been synthesized which could serve as antimicrobials and antioxidants. Benzothiazole derivatives (B₁-B₇) were synthesized by two-step reactions and the structures were confirmed through IR, mass and NMR spectroscopy. The compounds were evaluated for in vitro antioxidant and antimicrobial activities using standard methods. The results of antibacterial and antifungal activity showed that compound B₄ exhibited maximum activity against all the tested strains of microorganisms with the zone of inhibition 17.1-18.5 mm and MIC value 1.1-1.5μg/mL. Compound B₅ exhibited potent antioxidant activity. The compounds substituted with halogen on the aryl ring showed increased antimicrobial activity as seen in the case of compound B₄ (6-fluoro). The compounds substituted with a hydroxyl group (B₅) exhibited good antioxidant activity.

Current Bioactive Compounds published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Computed Properties of 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Oh, Se Young published the artcileDurability and polarization characteristics of PVA polarizing film prepared with a dichroic azo dye, HPLC of Formula: 92-36-4, the publication is Kongop Hwahak (2000), 11(4), 426-431, database is CAplus.

A novel dichroic azo dyes having a benzothiazole moiety were synthesized and used to prepare poly(vinyl alc.) (PVA)-based polarizing films for application in liquid crystal displays. The UV-Visible spectrum of PVA-dye polarizing film showed absorption bands corresponding to aromatic rings and dye chromophoric species at 326 and 584 nm. The polarization efficiency and the transmittance of PVA-dye polarizing film were significantly influenced by dye concentration, dipping time and addition of salt catalyst. The PVA-dye polarizing film exhibited a high polarization efficiency of 99.5% and a good transmittance of 42%. Especially, the heat and humidity resistance of PVA-dye polarizing film was higher than that of a conventional PVA-I₂ polarizing film.

Kongop Hwahak published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, HPLC of Formula: 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Li, Zijie published the artcileEfficient room temperature catalytic synthesis of alternating conjugated copolymers via C-S bond activation, Synthetic Route of 5053-24-7, the publication is Nature Communications (2022), 13(1), 144, database is CAplus and MEDLINE.

Structural defects in conjugated copolymers are severely detrimental to the optoelectronic properties and the performance of the resulting electronic devices fabricated from them. Therefore, the much-desired precision synthesis of conjugated copolymers with highly regular repeat units is important, but presents a significant challenge to synthetic materials chemists. To this end, aryl sulfides are naturally abundant substances and offer unrealized potential in cross-coupling reactions. Here we report an efficient room temperature polycondensation protocol which implements aryl disulfide C-S activation to produce defect-minimized semiconducting conjugated copolymers with broad scope and applicability. Thus, a broad series of arylstannanes and thioethers are employed via the present protocol to afford copolymers with number-average mol. weights (Mns) of 10.0-45.0 kDa. MALDI and NMR anal. of selected copolymers reveals minimal structural defects. Moreover, the polymer trap d. here is smaller and the field effect mobility higher than that in the analogous polymer synthesized through thermal-activation Stille coupling.

Nature Communications published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Synthetic Route of 5053-24-7.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Zhu, Yu-Shen published the artcileIodine-catalyzed amination of benzothiazoles with KSeCN in water to access primary 2-aminobenzothiazoles, Computed Properties of 95-24-9, the publication is Chinese Chemical Letters (2022), 33(3), 1497-1500, database is CAplus.

A facile and sustainable approach for the amination of benzothiazoles I (X = H, N; R = H, 4-Cl, 5-OMe, 6-NO₂, 7-C(O)OMe; R¹ = H) with KSeCN using iodine as the catalyst in water has been disclosed under transition-metal free conditions. The reaction proceeded smoothly to afford various primary 2-amino benzothiazoles I (R¹ = NH₂) in up to 96% yield. A series of control experiments were performed, suggesting that a ring-opening mechanism was involved via a radical process. This protocol provides efficient synthesis of primary 2-aminobenzothiazole I (R¹ = NH₂).

Chinese Chemical Letters published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C8H5F3O3, Computed Properties of 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Liu, Xiang-Wei published the artcileDiversified syntheses of multifunctionalized thiazole derivatives via regioselective and programmed C-H activation, Related Products of thiazole, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(22), 4599-4602, database is CAplus and MEDLINE.

The sequential construction of diversified multifunctionalized thiazole derivatives through Pd-catalyzed regioselective C-H alkenylation was accomplished. This versatile approach provides the diversified thiazole derivatives featuring orthogonal substitution patterns at the C-2, C-4 and C-5 positions from mono-substituted (2- or 4-substituted) thiazole derivatives or even more challenging simple thiazole.

Chemical Communications (Cambridge, United Kingdom) published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica