Design, Synthesis, and Anti-Inflammatory Evaluation of Novel Diphenylthiazole-Thiazolidinone Hybrids was written by Abdelazeem, Ahmed H.;Salama, Samir A.;Maghrabi, Ibrahim A.. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2015.Name: 4,5-Diphenylthiazol-2-amine This article mentions the following:
A series of diphenylthiazole-thiazolidinone hybrids was synthesized and evaluated in vitro and in vivo as anti-inflammatory/analgesic agents. The inhibition of cyclooxygenase (COX) enzymes was suggested as a mol. mechanism for the hybrids to exert their anti-inflammatory action. Of these compounds, 2-((4,5-diphenylthiazol-2-yl)imino)-5-(pyridin-3yl-methylene)thiazolidin-4-one (1), 2-((4,5-diphenylthiazol-2-yl)imino)-5-(naphthalen-1-yl-methylene)thiazolidin-4-one (2), and 2-((4,5-diphenylthiazol-2-yl)imino)-5-(3-nitrobenzylidene)thiazolidin-4-one (3) showed the most potent COX inhibitory activity with IC50 values between 2.03 and 12.27 μM, but with different selectivity profiles. All compounds were further evaluated in vivo for their anti-inflammatory/analgesic activities using three animal models. Interestingly, the results of the COX assay were in agreement with those of in vivo assays where the most potent COX inhibitors 1, 2, and 3 exhibited the highest anti-inflammatory/analgesic activities compared to diclofenac. On the contrary, 2-((4,5-diphenylthiazol-2-yl)imino)thiazolidin-4-one and 2-((4,5-diphenylthiazol-2-yl)imino)-5-(thiophen-2-yl-methylene)thiazolidin-4-one were the least potent ligands in vitro and in vivo as well. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Name: 4,5-Diphenylthiazol-2-amine).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Name: 4,5-Diphenylthiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica