Imidazole derivatives was written by Dash, B.;Mohapatra, P. K.. And the article was included in Journal of the Institution of Chemists (India) in 1984.COA of Formula: C15H12N2S This article mentions the following:
Imidazothiazoles I (R, R1 = H, 2-Cl, 4-Cl, 4-MeO; R2 = H, 4-Cl, 4-Me, 4-MeO) and imidazooxadiazoles II (R3 = H, 2-Cl, 4-Cl, 4-MeO; R4 = H, 4-Br, 4-Cl, 4-Me, 4-MeO) were prepared by cyclocondensation of substituted phenacyl bromides with 4,5-diaryl-2-thiazolamines or 5-aryl-1,3,4-oxadiazol-2-amines, resp. Mass fragmentation of I and II were studied to confirm their structures and compare fragmentation patterns of thiazoles and oxadiazoles. At 500 ppm I and II inhibited Curvularia species by 78-83% and 55-64%, resp. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7COA of Formula: C15H12N2S).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.COA of Formula: C15H12N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica