Solid-phase synthesis and modification of thiazole orange and its derivatives and their spectral properties was written by Fei, Xuening;Yang, Shaobin;Zhang, Baolian;Liu, Zhijun;Gu, Yingchun. And the article was included in Journal of Combinatorial Chemistry in 2007.Reference of 58759-63-0 This article mentions the following:
A new solid-phase synthesis is shown to be effective in the preparation of the cyanine dye thiazole orange (TO) and its derivatives, which can be obtained as a traceless cleavage of the Merrifield resin method. The influence of different solvents and substituent groups on benzothiazole (such as Cl, Me, and NO2) was extensively studied. The changes of the spectral characteristics and fluorescence intensity of the TO derivatives were described. The phenomenon of the synergetic effect was also depicted after modifying the TO mol. with chitosan oligosaccharide at the end of the alkyl, which can effectively improve the sensitivity of the fluorescent probe. In the experiment, the researchers used many compounds, for example, 5-Nitrobenzothiazole-2-thiol (cas: 58759-63-0Reference of 58759-63-0).
5-Nitrobenzothiazole-2-thiol (cas: 58759-63-0) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Reference of 58759-63-0
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica